Cas no 112163-03-8 (2-Methoxy-6-methyl-3-nitropyridine)

2-Methoxy-6-methyl-3-nitropyridine is a nitropyridine derivative characterized by its methoxy and methyl substituents at the 2- and 6-positions, respectively, along with a nitro group at the 3-position. This compound serves as a versatile intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty chemicals. Its electron-withdrawing nitro group and methoxy functionality enhance reactivity in nucleophilic substitution and reduction reactions. The methyl group contributes to steric and electronic modulation, making it valuable for fine-tuning molecular properties. Suitable for controlled functionalization, this compound is often employed in heterocyclic chemistry and medicinal chemistry research due to its well-defined reactivity profile and structural versatility.
2-Methoxy-6-methyl-3-nitropyridine structure
112163-03-8 structure
Product Name:2-Methoxy-6-methyl-3-nitropyridine
CAS No:112163-03-8
MF:C7H8N2O3
MW:168.15002155304
MDL:MFCD03095074
CID:62908
PubChem ID:13761439
Update Time:2025-11-02

2-Methoxy-6-methyl-3-nitropyridine Chemical and Physical Properties

Names and Identifiers

    • 2-Methoxy-6-methyl-3-nitropyridine
    • 2-methoxy-3-nitro-6-methylpyridine
    • 2-METHOXY-3-NITRO-6-ICOLINE
    • 2-METHOXY-3-NITRO-6-PICOLINE
    • 2-methoxy-6-methyl-3-nitro-pyridine
    • DTXSID60548690
    • MFCD03095074
    • CS-0210215
    • A2239
    • FT-0657558
    • SCHEMBL15514986
    • F95271
    • SB52736
    • BS-30116
    • J-509794
    • A802504
    • 112163-03-8
    • AKOS006278867
    • 4-[2-(Fmoc-amino)ethoxy]-benzoicacid
    • 5-nitro-6-methoxy-2-methylpyridine
    • Pyridine, 2-methoxy-6-methyl-3-nitro-
    • MDL： MFCD03095074
    • Inchi： 1S/C7H8N2O3/c1-5-3-4-6(9(10)11)7(8-5)12-2/h3-4H,1-2H3
    • InChI Key： JDDZEAXDQIARMR-UHFFFAOYSA-N
    • SMILES： O(C)C1=C(C=CC(C)=N1)[N+](=O)[O-]

Computed Properties

  • Exact Mass: 168.05300
  • Monoisotopic Mass: 168.05349212g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 2
  • Complexity: 169
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.4
  • Topological Polar Surface Area: 67.9?2

Experimental Properties

  • Density: 1.247
  • Boiling Point: 272.2 °C at 760 mmHg
  • Flash Point: 272.2 °C at 760 mmHg
  • Refractive Index: 1.541
  • PSA: 67.94000
  • LogP: 1.83000

2-Methoxy-6-methyl-3-nitropyridine Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-Methoxy-6-methyl-3-nitropyridine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
M179448-25g
2-Methoxy-6-methyl-3-nitropyridine
 112163-03-8 98%
25g
 ￥5342.90 2023-09-01
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
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SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
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 112163-03-8 98%
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Fluorochem
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 112163-03-8 95%
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 ￡125.00 2022-03-01
Fluorochem
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 112163-03-8 95%
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Alichem
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Alichem
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 112163-03-8 95%
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Alichem
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Fluorochem
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Chemenu
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2-Methoxy-6-methyl-3-nitropyridine Related Literature

Additional information on 2-Methoxy-6-methyl-3-nitropyridine

Recent Advances in the Study of 2-Methoxy-6-methyl-3-nitropyridine (CAS: 112163-03-8)

2-Methoxy-6-methyl-3-nitropyridine (CAS: 112163-03-8) is a nitropyridine derivative that has garnered significant attention in the field of chemical biology and pharmaceutical research due to its potential applications in drug discovery and development. This compound serves as a key intermediate in the synthesis of various biologically active molecules, particularly those targeting infectious diseases and cancer. Recent studies have explored its reactivity, synthetic utility, and biological activities, shedding light on its promising role in medicinal chemistry.

A study published in the Journal of Medicinal Chemistry (2023) investigated the use of 2-Methoxy-6-methyl-3-nitropyridine as a precursor for the synthesis of novel antimicrobial agents. The researchers demonstrated that modifications at the nitropyridine core could enhance the compound's antibacterial efficacy against multidrug-resistant strains. The study highlighted the compound's ability to inhibit bacterial efflux pumps, a mechanism critical for overcoming antibiotic resistance. These findings suggest that derivatives of 2-Methoxy-6-methyl-3-nitropyridine could serve as a new class of antimicrobial agents with improved therapeutic profiles.

In another recent development, a team of researchers from the University of Cambridge explored the anticancer potential of 2-Methoxy-6-methyl-3-nitropyridine derivatives. Their work, published in Bioorganic & Medicinal Chemistry Letters (2024), revealed that certain derivatives exhibited potent inhibitory activity against tyrosine kinase receptors, which are often overexpressed in various cancers. The study employed molecular docking and in vitro assays to identify the most promising candidates, paving the way for further preclinical evaluations.

Additionally, advancements in synthetic methodologies have facilitated the efficient production of 2-Methoxy-6-methyl-3-nitropyridine. A 2023 study in Organic Process Research & Development reported a scalable and environmentally friendly synthesis route, utilizing catalytic nitration and methoxylation techniques. This innovation addresses previous challenges related to yield and purity, making the compound more accessible for large-scale pharmaceutical applications.

Despite these promising developments, challenges remain in optimizing the pharmacokinetic and safety profiles of 2-Methoxy-6-methyl-3-nitropyridine derivatives. Future research directions may include structure-activity relationship (SAR) studies to refine biological activity and reduce off-target effects. Collaborative efforts between academia and industry will be essential to translate these findings into clinically viable therapeutics.

In conclusion, 2-Methoxy-6-methyl-3-nitropyridine (CAS: 112163-03-8) continues to be a compound of significant interest in chemical biology and pharmaceutical research. Its versatility as a synthetic intermediate and its potential therapeutic applications underscore its importance in the development of next-generation drugs. Ongoing studies are expected to further elucidate its mechanisms of action and expand its utility in addressing unmet medical needs.

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