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• 3. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzimidazoles Benzimidazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzimidazoles

Comprehensive Overview of 2-(1-Propyl-1H-benzimidazol-2-yl)aminoethanol (CAS No. 111678-86-5): Properties, Applications, and Innovations

2-(1-Propyl-1H-benzimidazol-2-yl)aminoethanol (CAS No. 111678-86-5) is a specialized organic compound that has garnered significant attention in pharmaceutical and material science research. This benzimidazole derivative is characterized by its unique molecular structure, combining a propyl-substituted benzimidazole core with an aminoethanol side chain. Such structural features make it a versatile intermediate for synthesizing advanced materials and bioactive molecules.

In recent years, the demand for high-performance heterocyclic compounds like 2-(1-Propyl-1H-benzimidazol-2-yl)aminoethanol has surged due to their applications in drug discovery and functional materials. Researchers are particularly interested in its potential as a building block for kinase inhibitors and antimicrobial agents, aligning with the global focus on combating antibiotic resistance. The compound's CAS No. 111678-86-5 is frequently searched in academic databases, reflecting its relevance in cutting-edge studies.

The synthesis of 2-(1-Propyl-1H-benzimidazol-2-yl)aminoethanol involves multi-step organic reactions, often starting from o-phenylenediamine derivatives. Its propyl group enhances lipophilicity, a property critical for improving bioavailability in pharmaceutical formulations. Meanwhile, the aminoethanol moiety introduces hydrogen-bonding capabilities, enabling interactions with biological targets. These attributes have led to its exploration in cancer therapeutics and neuroprotective agents, topics trending in biomedical forums.

Beyond pharmaceuticals, CAS 111678-86-5 is investigated for its role in advanced polymer coatings and corrosion inhibitors. Industries value its ability to form stable complexes with metal ions, a feature leveraged in material science innovations. Environmental sustainability concerns have also driven research into its green synthesis methods, addressing the demand for eco-friendly chemical processes—a hot topic in 2024 chemistry trends.

Analytical characterization of 2-(1-Propyl-1H-benzimidazol-2-yl)aminoethanol typically employs HPLC, NMR spectroscopy, and mass spectrometry. These techniques confirm its high purity (>98%), a prerequisite for research applications. The compound's stability under ambient conditions and solubility profile (soluble in DMSO, methanol) further enhance its utility in laboratory settings.

Emerging studies explore the compound's structure-activity relationships (SAR) to optimize its biological efficacy. Computational chemistry tools, including molecular docking simulations, predict its interactions with enzymes like CDK2 and EGFR—targets central to precision medicine developments. Such interdisciplinary approaches resonate with the growing interest in AI-driven drug design.

Regulatory databases list CAS 111678-86-5 as a research-grade chemical, with suppliers providing it in gram-to-kilogram quantities. Proper handling requires standard laboratory safety protocols, though it doesn't fall under restricted categories. Its non-hazardous nature facilitates global shipping, supporting collaborative research efforts.

Future directions for 2-(1-Propyl-1H-benzimidazol-2-yl)aminoethanol include nanocarrier functionalization for drug delivery and photoactive material development. These applications align with searches for "smart materials in healthcare" and "sustainable chemistry solutions," highlighting its cross-disciplinary potential.

• 60078-53-7(2-(2-(Methylamino)-1H-benzo[d]imidazol-1-yl)ethan-1-ol)
• 111678-92-3(1H-Benzimidazol-2-amine,N-(2-chloroethyl)-1-propyl-, hydrochloride (1:1))
• 631843-69-1(3-[(1-ethyl-1H-1,3-benzodiazol-2-yl)amino]propan-1-ol)
• 42076-32-4(1-Ethyl-N-prop-2-ynylbenzimidazol-2-amine)
• 301168-52-5(Pyrimido[1,2-a]benzimidazole,1,2,3,4-tetrahydro-1-methyl-)
• 57262-39-2(2-(1-Methyl-1H-benzoimidazol-2-ylamino)-ethanol)
• 111678-90-1(Ethanol,2-[[1-(phenylmethyl)-1H-benzimidazol-2-yl]amino]-, hydrochloride (1:1))
• 50616-11-0(N,1-Diethyl-1H-benzo[d]imidazol-2-amine)
• 111678-89-8(Ethanol,2-[(1-butyl-1H-benzimidazol-2-yl)amino]-, hydrochloride (1:1))
• 429646-29-7(1H-Benzimidazol-2-amine,N-methyl-1-propyl-)