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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Anilides

Comprehensive Overview of 2-Bromo-3-methyl-N-phenylbutanamide (CAS No. 111216-73-0): Properties, Applications, and Industry Insights

2-Bromo-3-methyl-N-phenylbutanamide (CAS No. 111216-73-0) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. This brominated amide derivative, characterized by its molecular formula C11H14BrNO, serves as a versatile intermediate in synthetic chemistry. Its distinctive bromine substitution and phenylbutanamide backbone make it a valuable building block for designing bioactive molecules, particularly in drug discovery programs targeting enzyme modulation.

Recent trends in organic synthesis highlight the growing demand for brominated amides like 2-Bromo-3-methyl-N-phenylbutanamide, as evidenced by increased patent filings and scholarly publications. Researchers are particularly interested in its potential as a chiral synthon for asymmetric synthesis, with studies demonstrating its utility in constructing complex heterocycles. The compound's crystalline solid form (typically white to off-white) and moderate solubility in polar aprotic solvents facilitate its handling in laboratory settings, while its melting point range of 98-102°C ensures stability under standard storage conditions.

From an industrial perspective, CAS 111216-73-0 has emerged as a cost-effective alternative to more elaborate bromination reagents. Manufacturers appreciate its high atom economy in reactions where selective bromine incorporation is required. Analytical techniques such as HPLC purity analysis (typically >97%) and NMR spectral characterization (showing distinctive peaks at 7.2-7.6 ppm for aromatic protons) have become standard quality control measures for this compound. These analytical protocols address the pharmaceutical industry's stringent requirements for impurity profiling of synthetic intermediates.

The environmental profile of 2-Bromo-3-methyl-N-phenylbutanamide has been extensively studied, with modern green chemistry approaches focusing on minimizing bromine waste during its synthesis. Recent process optimization efforts have achieved 85-90% yield improvements through catalytic bromination methods, responding to the chemical industry's sustainability initiatives. These advancements align with current searches for eco-friendly bromination techniques and halogenated compound handling protocols that dominate academic and industrial discourse.

In material science applications, the electron-withdrawing nature of the bromine moiety in 2-Bromo-3-methyl-N-phenylbutanamide has shown promise in modifying polymer properties. Studies indicate its potential as a cross-linking agent in specialty resins, particularly where controlled degradation properties are desired. This application has sparked interest in searches for halogen-containing polymer modifiers and thermal stabilizers, positioning the compound as a subject of ongoing materials research.

Quality specifications for CAS 111216-73-0 have become more rigorous in response to pharmaceutical Good Manufacturing Practice (GMP) requirements. Leading suppliers now provide detailed certificates of analysis including residual solvent profiles, heavy metal content, and microbiological testing data. This documentation addresses frequent queries about pharmaceutical-grade intermediates and QC standards for research chemicals that appear in scientific procurement searches.

Emerging research directions for 2-Bromo-3-methyl-N-phenylbutanamide include its investigation as a precursor for fluorescent probes, leveraging the bromine atom's heavy atom effect to enhance intersystem crossing. This application responds to the growing market for bioimaging reagents and molecular sensors. Additionally, its structure-activity relationships are being explored in medicinal chemistry programs targeting protein-protein interactions, a hot topic in drug discovery forums and academic conferences.

Storage and handling recommendations for 2-Bromo-3-methyl-N-phenylbutanamide emphasize protection from moisture (recommended desiccated storage at 2-8°C) and avoidance of strong oxidizers. These precautions address common laboratory safety questions while ensuring the compound's long-term stability. The development of stable crystalline polymorphs has further enhanced its shelf life, making it a reliable reagent for multi-step synthetic sequences.

Market analysis indicates steady growth in the fine chemicals sector for compounds like 2-Bromo-3-methyl-N-phenylbutanamide, driven by expanding contract research organizations and generic pharmaceutical development. Suppliers have responded by offering customized bulk packaging options and just-in-time delivery services to meet diverse research needs. This commercial evolution mirrors search trends emphasizing reliable chemical suppliers and scalable synthetic intermediates.

Future prospects for CAS 111216-73-0 include potential applications in catalysis (as a ligand precursor) and bioconjugation chemistry. The compound's balanced lipophilicity (predicted LogP of 2.8) makes it particularly interesting for prodrug development, a frequently searched topic in medicinal chemistry optimization. Ongoing structure modification studies aim to enhance its bioavailability parameters while maintaining the advantageous physicochemical properties of the parent molecule.

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