• 1. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 2. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
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• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
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• 5. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

Comprehensive Overview of 5-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS No. 1111638-01-7)

5-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS No. 1111638-01-7) is a heterocyclic compound that has garnered significant attention in the fields of medicinal chemistry and drug discovery. This compound belongs to the pyrrolopyridine family, a class of nitrogen-containing heterocycles known for their diverse biological activities. The presence of a bromine substituent and a phenylsulfonyl group in its structure makes it a valuable intermediate for the synthesis of more complex molecules, particularly in the development of kinase inhibitors and other therapeutic agents.

In recent years, the demand for pyrrolopyridine derivatives has surged due to their potential applications in targeting various diseases, including cancer and inflammatory disorders. Researchers are particularly interested in the 5-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine scaffold because of its ability to modulate key signaling pathways. The compound's unique structure allows for further functionalization, enabling the creation of libraries of analogs for high-throughput screening. This aligns with the growing trend in drug discovery to explore novel chemical spaces and optimize lead compounds for improved efficacy and safety.

The synthesis of 5-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine typically involves multi-step organic reactions, including halogenation and sulfonylation. Its CAS No. 1111638-01-7 serves as a unique identifier, ensuring accurate referencing in scientific literature and regulatory documents. The compound's physicochemical properties, such as solubility and stability, are critical for its application in pharmaceutical research. These properties are often optimized to enhance bioavailability and reduce off-target effects, which are common challenges in modern drug development.

From an industrial perspective, 5-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine is a high-value chemical used by contract research organizations (CROs) and pharmaceutical companies. Its role in the synthesis of kinase inhibitors is particularly noteworthy, as these inhibitors represent a major class of drugs for treating cancers and autoimmune diseases. The compound's versatility also extends to material science, where it can be incorporated into organic electronic devices due to its conjugated system and electron-rich nature.

In the context of sustainable chemistry, researchers are exploring greener synthetic routes for pyrrolopyridine derivatives to minimize environmental impact. This includes the use of catalytic methods and renewable solvents, which are increasingly important in the pharmaceutical industry. The compound's CAS No. 1111638-01-7 is often searched in databases like SciFinder and Reaxys, highlighting its relevance in academic and industrial research. Additionally, its structural features make it a candidate for computational chemistry studies, where molecular modeling can predict its interactions with biological targets.

As the field of precision medicine advances, the need for tailored therapeutics has never been greater. 5-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine offers a promising starting point for the design of next-generation drugs. Its compatibility with modern combinatorial chemistry techniques allows for rapid diversification, enabling researchers to explore structure-activity relationships (SAR) more efficiently. This is particularly valuable in the race to develop treatments for emerging health challenges, such as antibiotic resistance and neurodegenerative diseases.

In summary, 5-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS No. 1111638-01-7) is a versatile and highly functionalized compound with broad applications in drug discovery and material science. Its unique structural attributes and potential for further modification make it a valuable asset in the quest for innovative therapies and advanced materials. As research continues to uncover new uses for this compound, its importance in scientific and industrial settings is expected to grow exponentially.

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