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Comprehensive Overview of 5-(2,3-difluorophenyl)-2-hydroxybenzaldehyde (CAS No. 1111128-76-7): Properties, Applications, and Research Insights

5-(2,3-difluorophenyl)-2-hydroxybenzaldehyde (CAS No. 1111128-76-7) is a fluorinated aromatic aldehyde with significant potential in pharmaceutical and material science research. This compound, characterized by its difluorophenyl and hydroxybenzaldehyde moieties, has garnered attention for its unique electronic properties and reactivity. Researchers are increasingly exploring its role as a building block in organic synthesis, particularly in the development of fluorescent probes and bioactive molecules. Its structural features make it a versatile intermediate for designing drug candidates targeting inflammation and metabolic disorders.

The growing interest in fluorinated compounds like 5-(2,3-difluorophenyl)-2-hydroxybenzaldehyde aligns with trends in green chemistry and sustainable synthesis. Recent studies highlight its utility in catalysis and photocatalysis, addressing common queries such as "How do fluorinated aldehydes enhance reaction efficiency?" or "What are the applications of hydroxybenzaldehyde derivatives in medicinal chemistry?". The compound’s electron-withdrawing fluorine atoms improve stability and selectivity in cross-coupling reactions, a topic frequently searched in academic databases.

From an industrial perspective, CAS No. 1111128-76-7 is investigated for its potential in advanced materials, including OLEDs and liquid crystals. Its fluorescence properties are leveraged in sensor technologies, responding to demands for environmental monitoring tools. Analytical techniques like HPLC and NMR confirm its high purity (>98%), a critical factor for reproducibility in preclinical studies. Discussions on platforms like ResearchGate often emphasize its structure-activity relationships, reflecting user interest in molecular design strategies.

Safety and handling of 5-(2,3-difluorophenyl)-2-hydroxybenzaldehyde adhere to standard laboratory protocols, with no significant hazards reported. Its low toxicity profile expands its applicability in bioconjugation and peptide modification, areas trending in proteomics research. As synthetic methodologies evolve, this compound’s role in click chemistry and metal-organic frameworks (MOFs) continues to be a hot topic in peer-reviewed journals.

In summary, 5-(2,3-difluorophenyl)-2-hydroxybenzaldehyde exemplifies the convergence of organic chemistry and applied sciences. Its multifaceted applications—from drug discovery to functional materials—make it a subject of persistent exploration. Future research may focus on optimizing its scalable synthesis or exploiting its chiral properties, addressing gaps identified in recent patent filings and scientific literature.

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• 1111129-18-0(5-(2,6-difluorophenyl)-2-hydroxybenzaldehyde)
• 1111129-46-4(2-hydroxy-5-(2,4,6-trifluorophenyl)benzaldehyde)
• 1111129-23-7(5-(2-fluoro-5-methylphenyl)-2-hydroxybenzaldehyde)
• 1261925-66-9(2-hydroxy-4-(2,4,6-trifluorophenyl)benzaldehyde)
• 1111129-25-9(5-(3,4-difluorophenyl)-2-hydroxybenzaldehyde)
• 1111119-96-0(5-(2,5-difluorophenyl)-2-hydroxybenzaldehyde)
• 1111128-91-6(4-(4-Fluoro-3-methylphenyl)-2-formylphenol)
• 114937-29-0(5-(2,4-difluorophenyl)-2-hydroxybenzaldehyde)
• 1111129-26-0(4-(3-Fluoro-4-methylphenyl)-2-formylphenol)