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  Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles

Comprehensive Overview of 5-Bromo-2-fluoro-3-methylbenzonitrile (CAS No. 1110502-49-2): Properties, Applications, and Industry Trends

5-Bromo-2-fluoro-3-methylbenzonitrile (CAS No. 1110502-49-2) is a high-value halogenated benzonitrile derivative widely utilized in pharmaceutical intermediates, agrochemical synthesis, and advanced material research. This compound's unique molecular structure, featuring a bromine substituent at the 5-position, a fluorine at the 2-position, and a methyl group at the 3-position, grants it exceptional reactivity in cross-coupling reactions, making it a sought-after building block in modern organic chemistry.

The growing demand for fluorinated aromatic compounds in drug discovery—driven by their metabolic stability and bioavailability—has positioned 5-Bromo-2-fluoro-3-methylbenzonitrile as a key intermediate. Recent studies highlight its role in developing kinase inhibitors and anticancer agents, aligning with the pharmaceutical industry's focus on targeted therapies. Researchers frequently search for "synthetic routes for halogenated benzonitriles" or "applications of fluorinated nitriles in medicinal chemistry," reflecting this compound's relevance in cutting-edge science.

From a synthetic perspective, CAS 1110502-49-2 exhibits remarkable versatility. Its cyano group enables nucleophilic substitutions, while the bromo-fluoro pairing facilitates selective functionalization via Suzuki-Miyaura or Buchwald-Hartwig couplings. Industry reports emphasize its use in creating liquid crystal materials for OLED displays, responding to the surge in demand for energy-efficient technologies. Environmental considerations also drive interest in "green synthesis of bromo-fluorobenzonitriles," with recent patents exploring catalytic methods to reduce waste.

Analytical characterization of 5-Bromo-2-fluoro-3-methylbenzonitrile typically involves GC-MS, HPLC, and NMR spectroscopy, with the compound's purity (>98%) being critical for pharmaceutical applications. Storage recommendations include protection from light and moisture at 2–8°C, as its methylbenzonitrile core may degrade under prolonged heat exposure. These specifications are frequently queried in search engines as "stability of halogenated benzonitrile derivatives."

Market trends indicate rising procurement of CAS 1110502-49-2 by contract research organizations (CROs) specializing in proteolysis-targeting chimeras (PROTACs) development. The compound's ability to serve as a spacer or linker in bifunctional molecules has gained attention in 2023–2024, coinciding with increased investments in protein degradation therapeutics. Queries like "5-Bromo-2-fluoro-3-methylbenzonitrile supplier" or "bulk pricing for fluorinated nitrile intermediates" reflect commercial interest.

Regulatory compliance remains a key discussion point. While 5-Bromo-2-fluoro-3-methylbenzonitrile isn’t classified as hazardous under GHS, proper handling protocols are advised due to potential skin/eye irritation. Safety Data Sheets (SDS) emphasize using nitrile gloves and fume hoods during manipulation—a detail often searched alongside "benzonitrile derivative safety guidelines."

Innovative applications continue to emerge, particularly in covalent organic frameworks (COFs) and supramolecular chemistry. The compound's rigid aromatic structure and halogen handles make it ideal for constructing porous materials for gas storage—an area gaining traction due to hydrogen economy developments. Academic papers increasingly cite its use in designing fluorescent sensors, addressing the need for environmental pollutant detection.

In summary, 5-Bromo-2-fluoro-3-methylbenzonitrile (CAS 1110502-49-2) represents a multifaceted chemical asset bridging pharmaceuticals, materials science, and sustainable technology. Its evolving applications underscore the importance of halogenated aromatic building blocks in solving contemporary scientific challenges, from drug resistance to clean energy storage.

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