• 1. Catecholase activity of Mannich-based dinuclear CuII complexes with theoretical modeling: new insight into the solvent role in the catalytic cycle
  Ria Sanyal,Priyanka Kundu,Elena Rychagova,Grigory Zhigulin,Sergey Ketkov,Bipinbihari Ghosh,Shyamal Kumar Chattopadhyay,Ennio Zangrando,Debasis Das New J. Chem. 2016 40 6623
• 2. A coacervate-forming biodegradable polyester with elevated LCST based on bis-(2-methoxyethyl)amine
  J. P. Swanson,M. R. Martinez,M. A. Cruz,S. G. Mankoci,P. J. Costanzo,A. Joy Polym. Chem. 2016 7 4693
• 3. A coacervate-forming biodegradable polyester with elevated LCST based on bis-(2-methoxyethyl)amine
  J. P. Swanson,M. R. Martinez,M. A. Cruz,S. G. Mankoci,P. J. Costanzo,A. Joy Polym. Chem. 2016 7 4693
• 4. Four-, five-, and six-co-ordinate cobalt(II) and nickel(II) complexes with tetradentate ‘tripod-like’ nitrogen–oxygen and nitrogen–sulphur ligands
  L. Sacconi,R. Morassi J. Chem. Soc. A 1970 575
• 5. Nuclearity dependent solvent contribution to the catechol oxidase activity of novel copper(ii) complexes derived from Mannich-base ligand platforms: synthesis, crystal structure and mechanism
  Ria Sanyal,Sergey Ketkov,Suranjana Purkait,Franz A. Mautner,Grigory Zhigulin,Debasis Das New J. Chem. 2017 41 8586

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Secondary amines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

A Comprehensive Guide to Bis(2-Methoxyethyl)amine (CAS No. 111-95-5): Properties, Applications, and Industry Insights

Bis(2-Methoxyethyl)amine (CAS No. 111-95-5), also known as Bis(2-methoxyethyl)amine or N,N-Bis(2-methoxyethyl)amine, is a versatile organic compound widely utilized in industrial and research applications. This secondary amine features two methoxyethyl groups attached to a nitrogen atom, granting it unique solvation and reactivity properties. Its molecular formula is C₆H₁₅NO₂, with a molar mass of 133.19 g/mol. The compound typically appears as a colorless to pale yellow liquid with a faint amine-like odor, soluble in water and most organic solvents.

In recent years, Bis(2-Methoxyethyl)amine has gained attention in pharmaceutical intermediates and specialty chemical synthesis. Researchers frequently search for "Bis(2-Methoxyethyl)amine solubility" or "111-95-5 applications in drug discovery," reflecting its growing role in medicinal chemistry. The compound's ability to act as a ligand or catalyst precursor makes it valuable for asymmetric synthesis—a hot topic in green chemistry discussions. Environmental considerations have also driven interest in "biodegradable amine derivatives," positioning this compound as a subject of sustainable chemistry research.

The industrial uses of Bis(2-Methoxyethyl)amine span multiple sectors. In polymer chemistry, it serves as a chain modifier for polyurethanes and epoxy resins, with manufacturers often querying "amine-functionalized ethers for polymer modification." The electronics industry employs it in photoresist formulations, particularly for semiconductor manufacturing processes where "high-purity amine solvents for lithography" are crucial. Analytical chemists value its properties as a mobile phase modifier in HPLC separations, evidenced by searches for "111-95-5 HPLC applications."

From a safety perspective, proper handling of Bis(2-Methoxyethyl)amine requires standard laboratory precautions. While not classified as hazardous under normal conditions, material safety data sheets (MSDS) recommend using personal protective equipment—a frequently searched topic alongside "CAS 111-95-5 storage requirements." The compound demonstrates good stability under recommended storage conditions (typically 2-8°C in amber glass containers), though users often inquire about "amine compound shelf life" and "compatibility with common container materials."

Emerging research directions for Bis(2-Methoxyethyl)amine include its potential in energy storage systems. Recent patent literature reveals investigations into its use as an electrolyte additive for lithium-ion batteries, correlating with increased searches for "amine-based battery performance enhancers." The compound's electron-donating properties also make it a candidate for organic photovoltaic materials, aligning with renewable energy trends and searches for "organic semiconductor precursors." These applications demonstrate how traditional chemicals find new relevance in cutting-edge technologies.

Quality specifications for Bis(2-Methoxyethyl)amine vary by application, with purity requirements ranging from technical grade (≥95%) to research grade (≥99%). Analytical certificates typically include parameters like water content (often <0.5%), residual solvents, and amine value—details frequently sought under "111-95-5 technical specifications." The compound's IR and NMR spectra are well-documented, supporting its identification in quality control procedures, a concern reflected in queries about "Bis(2-Methoxyethyl)amine spectroscopic data."

Market trends indicate steady demand for Bis(2-Methoxyethyl)amine, particularly in Asia-Pacific regions where specialty chemical production is expanding. Industry reports often cite its role in the synthesis of corrosion inhibitors and textile auxiliaries—applications generating searches for "methoxyethylamine derivatives in industrial formulations." The compound's relative stability and moderate reactivity make it preferable to more volatile alternatives in many processes, explaining persistent interest in "low-odor amine reagents" across multiple industries.

Future developments may explore the enzymatic modification of Bis(2-Methoxyethyl)amine, as biotransformation becomes increasingly important in sustainable chemistry. Academic literature shows preliminary work on microbial degradation pathways, responding to inquiries about "biocatalytic amine functionalization." Such innovations could expand its utility in pharmaceutical synthesis while addressing environmental concerns—a dual benefit that aligns with current "green chemistry in amine synthesis" research trends.

• 38256-93-8((2-methoxyethyl)(methyl)amine)
• 105399-87-9(Ethanamine, 2,2'-oxybis[N-(2-methoxyethyl)-)
• 98366-79-1(6A-deoxy-6A-[(2-methoxyethyl)amino]-beta-Cyclodextrin)
• 38256-95-0((2-ethoxyethyl)(ethyl)amine)
• 124-21-0(Bis(2-ethoxyethyl)amine)
• 98961-84-3(2-(2-Ethoxyethyl)aminoethanol)
• 91598-32-2(Ethanol, 2-[[2-(2-aminoethoxy)ethyl]amino]-)
• 34322-82-2(N-(2-Methoxyethyl)ethylamine)
• 294-92-8(4,10-Diaza-12-crown 4-Ether)
• 138036-64-3(Ethanamine, 2-methoxy-N-(2-methoxyethyl)-, hydrochloride)