Cas no 111-77-3 (Methyl-PEG2-alcohol)
Methyl-PEG2-alcohol Chemical and Physical Properties
Names and Identifiers
-
- 2-(2-Methoxyethoxy)ethanol
- 2,2'-oxybisethanol monomethyl ether
- 2-beta-methyl carbitol
- 3,6-dioxa-1-heptanol
- 3,6-Dioxaheptan-1-ol
- Diethylene glycol methyl ether
- Diethylene Glycol Monomethyl Ether
- diglycol monomethyl ether
- beta-methoxy-beta'-hydroxydiethyl ether
- dowanol dm
- ektasolve dm
- ethylene diglycol monomethyl ether
- glycol ether dm
- hicotol car
- MECB
- methoxydiglycol
- methoxyethoxyethanol
- methyl digol
- methyl dioxitol
- Methyl Carbitol
- Poly-Solv DM
- Diethylene Glycol Monomethyl Ether (stabilized with BHT)
- Diethylene glycol monomethyl ether(DM)
- 2-(2-Methoxyethoxy)-Ethanol
- 2-(2-Methoxyethoxy)ethanol,Methyldiglycol
- 2-(2-Methoxyethoxy)ethanol (stabilized with BHT)
- Methyl Carbitol (stabilized with BHT)
- mPEG2-Alcohol (stabilized with BHT)
- Methyldiglycol
- degme
- DIEGME
- dowanol16
- jeffersoldm
- DM
- 2-(2-
- ektasolvedm
- methyldigol
- Ethanol, 2-(2-methoxyethoxy)-
- Diethyleneglycol monomethyl ether
- Methyl karbitol
- Jeffersol DM
- Dowanol 16
- Caswell No. 338B
- EGME, di-
- Methyl karbitol [Czech]
- Methyl-PEG2-alcohol
-
- MDL： MFCD00002871
- Inchi： 1S/C5H12O3/c1-7-4-5-8-3-2-6/h6H,2-5H2,1H3
- InChI Key： SBASXUCJHJRPEV-UHFFFAOYSA-N
- SMILES： O(C([H])([H])C([H])([H])O[H])C([H])([H])C([H])([H])OC([H])([H])[H]
- BRN： 1697812
Computed Properties
- Exact Mass: 120.07900
- Monoisotopic Mass: 120.078644
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 8
- Rotatable Bond Count: 5
- Complexity: 38.7
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: -0.9
- Topological Polar Surface Area: 38.7
Experimental Properties
- Color/Form: A colorless liquid with a slightly aromatic aroma and a slightly bitter taste.
- Density: 1.023?g/mL?at 25?°C(lit.)
- Melting Point: ?70?°C (lit.)
- Boiling Point: 194?°C(lit.)
- Flash Point: Fahrenheit: 188.6 ° f < br / > Celsius: 87 ° C < br / >
- Refractive Index: n20/D 1.426(lit.)
- PH: 4-7 (200g/l, H2O, 20℃)
- Solubility: Soluble in water, chloroform, ethanol and ether, miscible in alcohols, ketones and hydrocarbons.
- Water Partition Coefficient: Miscible
- Stability/Shelf Life: Stable. Incompatible with strong oxidizing agents. Hygroscopic. Store under nitrogen.
- PSA: 38.69000
- LogP: -0.35830
- Merck: 6037
- Vapor Pressure: 0.2 mmHg ( 20 °C)
- Sensitiveness: Hygroscopic
- FEMA: 2540
- Solubility: It can be miscible with water, alcohol, ether, acetone, carbon tetrachloride, glycerol, dimethylformamide, etc. Dissolve oils, natural resins, dyes, cellulose acetate, nitrocellulose, polyvinyl acetate, vinyl chloride vinyl acetate copolymer, etc.
Methyl-PEG2-alcohol Security Information
-
Symbol:
- Prompt：dangerous
- Signal Word：Warning
- Hazard Statement： H361
- Warning Statement： P281
- Hazardous Material transportation number：NA 1993 / PGIII
- WGK Germany：3
- Hazard Category Code： 63
- Safety Instruction： S36/37
- RTECS：KL6125000
-
Hazardous Material Identification：
- TSCA：Yes
- Toxicity：LD50 orally in rats: 9.21 g/kg (Smyth)
- Explosive Limit：1.38-22.7%
- Storage Condition：Inert atmosphere,Room Temperature
- Safety Term：S36/37
- Risk Phrases：R63
Methyl-PEG2-alcohol Customs Data
- HS CODE：2909440000
- Customs Data：
China Customs Code:
2909499000Overview:
2909499000 Other ether alcohols and their halogenation\sulfonation\Nitrosative or nitrosative derivatives. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%
Methyl-PEG2-alcohol Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | D806759-10L |
Diethylene glycol monomethyl ether |
111-77-3 | >99.0%(GC) | 10L |
680.00 | 2021-05-17 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | D806761-2.5L |
Diethylene glycol monomethyl ether |
111-77-3 | 98% | 2.5L |
199.00 | 2021-05-17 | |
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C0654540223- 500ml(玻瓶) |
Methyl-PEG2-alcohol |
111-77-3 | 500ml |
￥ 72.9 | 2021-05-18 | ||
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C0654540323- 500ml(玻瓶) |
Methyl-PEG2-alcohol |
111-77-3 | 500ml |
￥ 69.1 | 2021-05-18 | ||
| Fluorochem | 208688-100g |
2-(2-Methoxyethoxy)ethanol (stabilized with BHT) |
111-77-3 | 95% | 100g |
￡10.00 | 2022-03-01 | |
| Fluorochem | 208688-500ml |
2-(2-Methoxyethoxy)ethanol (stabilized with BHT) |
111-77-3 | 95% | 500ml |
￡42.00 | 2022-03-01 | |
| TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd. | M0537-500ML |
Diethylene Glycol Monomethyl Ether (stabilized with BHT) |
111-77-3 | >99.0%(GC) | 500ml |
￥230.00 | 2024-04-18 | |
| TRC | M220443-5g |
2-(2-Methoxyethoxy)ethanol |
111-77-3 | 5g |
$144.00 | 2023-05-18 | ||
| TRC | M220443-10g |
2-(2-Methoxyethoxy)ethanol |
111-77-3 | 10g |
$ 65.00 | 2022-06-04 | ||
| TRC | M220443-50g |
2-(2-Methoxyethoxy)ethanol |
111-77-3 | 50g |
$ 80.00 | 2022-06-04 |
Methyl-PEG2-alcohol Suppliers
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Methyl-PEG2-alcohol Related Literature
-
Ceara MacInnis,Pamela Brunswick,Jeffrey Yan,Marcus Kim,Graham Van Aggelen,Dayue Shang Anal. Methods 2019 11 3671
-
Rocco Bussolati,Pasquale Carrieri,Andrea Secchi,Arturo Arduini,Alberto Credi,Monica Semeraro,Margherita Venturi,Serena Silvi,Diana Velluto,Romina Zappacosta,Antonella Fontana Org. Biomol. Chem. 2013 11 5944
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Leon F. Scherz,Engy A. Abdel-Rahman,Sameh S. Ali,A. Dieter Schlüter,Mona A. Abdel-Rahman Med. Chem. Commun. 2017 8 662
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Leon F. Scherz,Engy A. Abdel-Rahman,Sameh S. Ali,A. Dieter Schlüter,Mona A. Abdel-Rahman Med. Chem. Commun. 2017 8 662
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Manabu Hatano,Kazuaki Ishihara Chem. Commun. 2013 49 1983
Related Categories
- Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Dialkyl ethers
- Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Dialkyl ethers
- Solvents and Organic Chemicals Organic Compounds Alcohol/Ether
- Other Chemical additives
- Solvents and Organic Chemicals Organic Solvents
- Catalysts and Inorganic Chemicals Catalysts
Additional information on Methyl-PEG2-alcohol
Professional Introduction to Methyl-PEG2-alcohol (CAS No. 111-77-3)
Methyl-PEG2-alcohol, a compound with the chemical name 2-(hydroxymethyl)-1-(methylthiomethyl)oxetane, is a versatile monomer widely utilized in the field of pharmaceuticals, biotechnology, and materials science. Its molecular structure, characterized by a PEG (Polyethylene Glycol) chain of 2 units, endows it with unique properties that make it invaluable in various applications. This introduction delves into the compound's properties, synthesis, applications, and recent advancements in research.
The CAS number 111-77-3 uniquely identifies Methyl-PEG2-alcohol in the chemical industry. This numbering system ensures precise identification and differentiation of chemical substances, which is crucial for regulatory compliance and scientific communication. The compound belongs to the class of glycol ethers, known for their solvency, low toxicity, and biocompatibility. These attributes have positioned Methyl-PEG2-alcohol as a preferred choice in drug formulation and polymer chemistry.
Methyl-PEG2-alcohol is synthesized through a series of well-established chemical reactions. The synthesis typically involves the reaction of ethylene oxide with methanethiol under controlled conditions. This process yields a protected form of PEG alcohol, which is then further functionalized to achieve the desired molecular weight and functionality. The synthesis pathway is optimized to ensure high purity and yield, making it suitable for industrial-scale production.
The primary application of Methyl-PEG2-alcohol lies in its role as a crosslinking agent in hydrogel formation. Hydrogels are three-dimensional networks of hydrophilic polymers that can absorb significant amounts of water while maintaining their structural integrity. These materials are widely used in drug delivery systems, wound dressings, and tissue engineering scaffolds. The incorporation of Methyl-PEG2-alcohol into hydrogel formulations enhances their mechanical stability and biocompatibility, making them more suitable for medical applications.
In the realm of pharmaceuticals, Methyl-PEG2-alcohol serves as a crucial intermediate in the development of prodrugs. Prodrugs are pharmacologically inactive compounds that are converted into active drugs within the body. The PEG moiety in Methyl-PEG2-alcohol helps to mask the pharmacophore of active drugs, improving their solubility and bioavailability. Recent studies have highlighted its role in enhancing the efficacy of anticancer drugs by improving their cellular uptake and reducing systemic toxicity.
The use of Methyl-PEG2-alcohol in nanotechnology has also gained significant traction. Nanoparticles functionalized with PEG chains exhibit improved circulation times in blood plasma due to their stealth characteristics. This property is particularly beneficial in targeted drug delivery systems, where prolonged circulation allows for more effective accumulation at target sites. Research has demonstrated the successful application of PEGylated nanoparticles in delivering siRNA for gene silencing therapy.
Advancements in material science have further expanded the applications of Methyl-PEG2-alcohol. Researchers have developed novel polymeric materials with tailored properties using this monomer as a building block. These materials exhibit enhanced thermal stability, mechanical strength, and chemical resistance, making them suitable for high-performance applications such as coatings and adhesives.
The environmental impact of using Methyl-PEG2-alcohol has been a subject of increasing interest. Studies have shown that PEG-based polymers are biodegradable under certain conditions, reducing concerns about long-term environmental persistence. However, the synthesis and disposal processes must be carefully managed to minimize ecological footprints. Efforts are ongoing to develop more sustainable synthetic routes and recycling methods for PEG derivatives.
In conclusion, Methyl-PEG2-alcohol (CAS No. 111-77-3) is a multifunctional compound with broad applications across various industries. Its unique properties make it an indispensable tool in pharmaceuticals, biotechnology, and materials science. As research continues to uncover new possibilities, the role of Methyl-PEG2-alcohol is expected to expand even further, driving innovation in multiple sectors.
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