• 1. Solid-phase fluoroimmunoassay for the determination of mesotrione —a novel triketone herbicide— in water with direct measurement of the fluorescence onto the solid support
  Christos Mastichiadis,Ion Christofidis,Michael A. Koupparis,Caroline Willetts,Sotiris E. Kakabakos Analyst 2003 128 404
• 2. Photosynthetic responses and accumulation of mesotrione in two freshwater algae
  Yan Ni,Jinhu Lai,Jinbao Wan,Lianshui Chen Environ. Sci.: Processes Impacts 2014 16 2288

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Nitrobenzoic acids and derivatives

Recent Advances in the Study of 4-Methylsulfonyl-2-nitrobenzoic Acid (CAS: 110964-79-9)

4-Methylsulfonyl-2-nitrobenzoic Acid (CAS: 110964-79-9) has recently emerged as a compound of significant interest in chemical biology and pharmaceutical research. This sulfonyl-containing nitrobenzoic acid derivative has shown promising potential in various applications, particularly in medicinal chemistry and drug development. Recent studies have focused on its unique chemical properties, synthetic utility, and biological activities, making it a valuable scaffold for further investigation.

A 2023 study published in the Journal of Medicinal Chemistry explored the compound's role as a key intermediate in the synthesis of novel kinase inhibitors. The research team demonstrated that the methylsulfonyl and nitro groups at the 2-position of the benzoic acid scaffold provide excellent hydrogen-bond acceptor properties, making it particularly suitable for targeting ATP-binding pockets in various kinases. The study reported successful derivatization of 4-Methylsulfonyl-2-nitrobenzoic Acid to produce several potent inhibitors with IC50 values in the nanomolar range against selected cancer-related kinases.

In the field of antibacterial research, a recent publication in Bioorganic & Medicinal Chemistry Letters (2024) highlighted the compound's utility in developing new antibacterial agents. The electron-withdrawing properties of both the nitro and methylsulfonyl groups were found to significantly enhance the reactivity of the benzoic acid core, allowing for efficient coupling with various pharmacophores. This approach led to the development of several novel compounds showing promising activity against drug-resistant bacterial strains, particularly MRSA and ESBL-producing E. coli.

From a synthetic chemistry perspective, advances in the preparation and purification of 4-Methylsulfonyl-2-nitrobenzoic Acid have been reported in several recent publications. A 2023 Organic Process Research & Development paper described an improved synthetic route that increases yield while reducing environmental impact through greener solvent systems and catalytic methods. These process improvements are particularly important given the growing demand for this compound in pharmaceutical development pipelines.

The compound's unique structural features have also attracted attention in materials science applications. A 2024 study in Advanced Materials demonstrated its potential as a building block for organic electronic materials, where the strong electron-withdrawing groups facilitate charge transport in organic semiconductors. This interdisciplinary application suggests broader potential for 4-Methylsulfonyl-2-nitrobenzoic Acid beyond traditional pharmaceutical uses.

Looking forward, several research groups have indicated ongoing investigations into the biological activities of novel derivatives based on this scaffold. Preliminary results suggest potential applications in inflammation modulation and neurodegenerative disease treatment, though these findings are still in early stages. The compound's versatility and the recent methodological advances in its manipulation position it as an important tool for future drug discovery efforts across multiple therapeutic areas.

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