• 1. Aggregation dynamics, structure, and mechanical properties of bigels
  L. Di Michele,D. Fiocco,F. Varrato,E. Eiser,G. Foffi Soft Matter, 2014,10, 3633-3648
• 2. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 3. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 4. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 5. An ionic liquid-based synergistic extraction strategy for rare earths?
  Yingbo Li,Nada Mehio,Huizhou Liu,Sheng Dai Green Chem., 2015,17, 2981-2993

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azetidines Azetidinecarboxylic acids or derivatives Azetidinecarboxylic acids

Recent Advances in the Application of 1-Tert-butyl 3-ethyl 3-carbamoylazetidine-1,3-dicarboxylate (CAS: 1105663-94-2) in Chemical Biology and Pharmaceutical Research

The compound 1-Tert-butyl 3-ethyl 3-carbamoylazetidine-1,3-dicarboxylate (CAS: 1105663-94-2) has emerged as a key intermediate in the synthesis of bioactive molecules and pharmaceutical agents. Recent studies have highlighted its utility in the development of novel therapeutic candidates, particularly in the areas of protease inhibition and targeted drug delivery. This research brief synthesizes the latest findings on this compound, focusing on its chemical properties, synthetic applications, and potential therapeutic implications.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers demonstrated the efficacy of 1-Tert-butyl 3-ethyl 3-carbamoylazetidine-1,3-dicarboxylate as a precursor in the synthesis of selective cathepsin inhibitors. The compound's unique azetidine scaffold and carboxylate functionalities were leveraged to enhance binding affinity and selectivity, resulting in inhibitors with improved pharmacokinetic profiles. This work underscores the compound's potential in addressing unmet medical needs in inflammatory and oncological diseases.

Further investigations have explored the compound's role in PROTAC (Proteolysis Targeting Chimera) development. A recent Nature Chemical Biology publication (2024) detailed its incorporation into bifunctional molecules designed to target undruggable proteins. The tert-butyl and ethyl ester groups were found to provide optimal linker geometry for E3 ligase recruitment, while the carbamoyl moiety contributed to target protein engagement. These findings position 1105663-94-2 as a valuable building block in next-generation targeted protein degradation strategies.

From a synthetic chemistry perspective, advances in the scalable production of 1-Tert-butyl 3-ethyl 3-carbamoylazetidine-1,3-dicarboxylate have been reported. A 2024 Organic Process Research & Development article described an improved catalytic asymmetric synthesis route with 92% enantiomeric excess, addressing previous challenges in stereocontrol. This methodological breakthrough has significant implications for the cost-effective production of chiral pharmaceuticals derived from this intermediate.

Emerging applications in radiopharmaceuticals have also been documented. The compound's ability to serve as a chelator scaffold for diagnostic radionuclides was demonstrated in recent preclinical studies (European Journal of Nuclear Medicine and Molecular Imaging, 2024). When functionalized with gallium-68 or copper-64, derivatives showed promising tumor-targeting capabilities in PET imaging, suggesting potential theranostic applications.

In conclusion, 1-Tert-butyl 3-ethyl 3-carbamoylazetidine-1,3-dicarboxylate (1105663-94-2) continues to demonstrate versatility across multiple pharmaceutical research domains. Its structural features enable diverse modifications that address contemporary challenges in drug discovery, from protein degradation to molecular imaging. Ongoing research is expected to further expand its applications, particularly in targeted therapies and personalized medicine approaches.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)