Cas no 1101120-80-2 (5-Cyano-2-fluorobenzene-1-sulfonyl chloride)

5-Cyano-2-fluorobenzene-1-sulfonyl chloride is a versatile sulfonylating reagent used in organic synthesis and pharmaceutical intermediates. Its key structural features—a cyano group and a fluorine substituent—enhance reactivity and selectivity in nucleophilic substitution reactions, making it valuable for constructing sulfonamides and sulfonate esters. The electron-withdrawing nature of the cyano and fluorine groups facilitates efficient sulfonylation under mild conditions. This compound is particularly useful in medicinal chemistry for introducing sulfonyl moieties into target molecules. High purity and stability ensure consistent performance in synthetic applications. Proper handling is required due to its moisture sensitivity and reactivity with nucleophiles.
5-Cyano-2-fluorobenzene-1-sulfonyl chloride structure
1101120-80-2 structure
Product Name:5-Cyano-2-fluorobenzene-1-sulfonyl chloride
CAS No:1101120-80-2
MF:C7H3ClFNO2S
MW:219.620622873306
MDL:MFCD18394026
CID:1024390
Update Time:2025-11-02

5-Cyano-2-fluorobenzene-1-sulfonyl chloride Chemical and Physical Properties

Names and Identifiers

    • 5-Cyano-2-fluorobenzene-1-sulfonyl chloride
    • 5-cyano-2-fluorobenzenesulfonyl chloride
    • 5-CYANO-2-FLUOROPHENYLSULFONYL CHLORIDE
    • CL8746
    • FCH927593
    • 1928AA
    • AB0061162
    • AX8231732
    • ST24024067
    • MDL： MFCD18394026
    • Inchi： 1S/C7H3ClFNO2S/c8-13(11,12)7-3-5(4-10)1-2-6(7)9/h1-3H
    • InChI Key： XLPGJVFDGAPUIH-UHFFFAOYSA-N
    • SMILES： ClS(C1C(=CC=C(C#N)C=1)F)(=O)=O

Computed Properties

  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 13
  • Rotatable Bond Count: 1
  • Complexity: 328
  • Topological Polar Surface Area: 66.3

5-Cyano-2-fluorobenzene-1-sulfonyl chloride Security Information

5-Cyano-2-fluorobenzene-1-sulfonyl chloride Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
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5-Cyano-2-fluorobenzene-1-sulfonyl chloride Related Literature

Additional information on 5-Cyano-2-fluorobenzene-1-sulfonyl chloride

Comprehensive Overview of 5-Cyano-2-fluorobenzene-1-sulfonyl chloride (CAS No. 1101120-80-2)

5-Cyano-2-fluorobenzene-1-sulfonyl chloride (CAS No. 1101120-80-2) is a specialized sulfonyl chloride derivative widely utilized in pharmaceutical and agrochemical research. This compound, characterized by its cyano and fluoro functional groups, serves as a critical intermediate in the synthesis of bioactive molecules. Its unique structure enables applications in cross-coupling reactions and heterocyclic compound formation, aligning with current trends in green chemistry and sustainable synthesis.

In recent years, the demand for fluorinated building blocks like 5-Cyano-2-fluorobenzene-1-sulfonyl chloride has surged due to their role in developing FDA-approved drugs and crop protection agents. Researchers frequently search for "sulfonyl chloride applications" or "fluorobenzene derivatives in drug discovery," reflecting its relevance in high-throughput screening and medicinal chemistry. The compound’s electron-withdrawing properties enhance reactivity, making it indispensable for designing kinase inhibitors and antibacterial compounds.

The synthesis of 5-Cyano-2-fluorobenzene-1-sulfonyl chloride involves regioselective halogenation and sulfonation, processes optimized for low environmental impact. Industry professionals often inquire about "scalable synthesis of sulfonyl chlorides" or "safe handling of reactive intermediates," underscoring the need for process optimization and safety protocols. Analytical techniques such as HPLC and NMR are employed to ensure purity, a key factor for GMP compliance in pharmaceutical manufacturing.

Emerging applications of 5-Cyano-2-fluorobenzene-1-sulfonyl chloride include its use in proteolysis-targeting chimeras (PROTACs), a cutting-edge field in targeted protein degradation. This aligns with trending searches like "PROTAC linker chemistry" and "fluorinated degraders." Its compatibility with click chemistry further expands utility in bioconjugation and diagnostic probe development, addressing needs in precision medicine.

From an SEO perspective, keywords such as "buy 5-Cyano-2-fluorobenzene-1-sulfonyl chloride," "CAS 1101120-80-2 suppliers," and "fluorobenzene sulfonyl chloride price" are frequently queried, highlighting commercial interest. The compound’s patent landscape reveals innovations in anticancer drug candidates, reinforcing its value in IP-driven research. Regulatory-compliant documentation, including COA and MSDS, ensures seamless integration into global supply chains.

In summary, 5-Cyano-2-fluorobenzene-1-sulfonyl chloride (CAS No. 1101120-80-2) exemplifies the convergence of structural versatility and industrial applicability. Its role in advancing life sciences and material innovation positions it as a cornerstone in modern organic synthesis, resonating with both academic and commercial stakeholders.

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