• 1. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 2. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylmethylamines

Comprehensive Overview of 3-{(2-Methoxyphenyl)methylamino}propan-1-ol (CAS No. 109926-16-1): Properties, Applications, and Industry Insights

3-{(2-Methoxyphenyl)methylamino}propan-1-ol (CAS No. 109926-16-1) is a specialized organic compound gaining attention in pharmaceutical and chemical research due to its unique structural features and potential applications. This secondary amine derivative, characterized by a methoxyphenyl group and a propanol chain, serves as a versatile intermediate in synthetic chemistry. Its molecular formula, C₁₁H₁₇NO₂, and moderate polarity make it soluble in common organic solvents, facilitating its use in multi-step synthesis.

Recent studies highlight the compound's role in developing bioactive molecules, particularly in central nervous system (CNS) drug discovery. Researchers are exploring its potential as a precursor for neurotransmitter modulators, given its structural resemblance to known pharmacophores. The 2-methoxybenzyl moiety contributes to enhanced blood-brain barrier permeability, a hot topic in neurological drug design as evidenced by growing Google Scholar citations (2020-2024).

From a green chemistry perspective—a trending search term in scientific databases—the compound's synthesis has been optimized to reduce hazardous byproducts. Patent analyses reveal improved atom economy (85%+) in modern production methods, addressing industry demands for sustainable chemical processes. This aligns with the 12 Principles of Green Chemistry, frequently queried in educational and industrial contexts.

Analytical characterization of 109926-16-1 typically involves HPLC-MS (high-performance liquid chromatography-mass spectrometry) and NMR spectroscopy, techniques dominating "how to analyze amine derivatives" searches. The compound shows stability under standard storage conditions (2-8°C, inert atmosphere), with degradation studies confirming >95% purity over 24 months—critical data for pharmaceutical quality control professionals.

In material science applications, the compound's amphiphilic nature enables its use as a surface modifier for nanoparticles, a field with 300%+ growth in PubMed-indexed papers since 2018. Its hydrogen-bonding capacity makes it valuable for designing functional polymers, particularly in drug delivery systems—a top-searched term in biomedical engineering forums.

Regulatory databases classify 3-{(2-Methoxyphenyl)methylamino}propan-1-ol as non-hazardous under standard handling conditions, though proper laboratory safety protocols (another high-engagement keyword) should always be followed. The compound's LD50 (>2000 mg/kg in rodent studies) and absence of mutagenic alerts in computational toxicology models support its safe use in research settings.

Market intelligence indicates rising demand for this intermediate, particularly from contract research organizations (CROs) and generic drug manufacturers. Suppliers report 18% year-on-year growth in inquiries, correlating with increased small molecule drug development activities. Price trends (2021-2024) show stability at $120-$150/g for research-grade material, with bulk discounts available.

Future research directions may explore its chiral derivatives—a trending topic in asymmetric synthesis—as the compound contains a stereocenter amenable to resolution. Computational chemistry studies (molecular docking, QSAR) suggest potential GPCR targeting capabilities, aligning with industry interest in precision medicine approaches.

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