• 1. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
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• 2. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
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• 3. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
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• 5. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzothiophenes 1-benzothiophenes

5-Fluoro-1-benzothiophene-2-carboxamide: A Comprehensive Overview

The compound 5-Fluoro-1-benzothiophene-2-carboxamide, also known by its CAS number 1098356-12-7, is a fascinating molecule that has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This compound belongs to the broader class of benzothiophene derivatives, which are known for their unique electronic properties and potential applications in drug discovery and advanced materials. In this article, we will delve into the structural characteristics, synthesis methods, pharmacological activities, and recent research findings related to this compound.

Benzothiophene derivatives are heterocyclic compounds that consist of a benzene ring fused to a thiophene ring. The presence of sulfur in the thiophene ring imparts distinct electronic properties to these compounds, making them valuable in various applications. The substitution pattern on the benzothiophene framework plays a crucial role in determining its chemical reactivity and biological activity. In the case of 5-Fluoro-1-benzothiophene-2-carboxamide, the fluorine atom at position 5 and the carboxamide group at position 2 introduce additional functional groups that further modulate its properties.

The synthesis of 5-Fluoro-1-benzothiophene-2-carboxamide typically involves multi-step organic reactions. Recent studies have focused on optimizing synthetic routes to improve yield and purity. For instance, researchers have employed methodologies such as Suzuki coupling reactions, Friedel-Crafts acylation, and nucleophilic substitution to construct this compound efficiently. These advancements not only enhance the scalability of synthesis but also pave the way for further functionalization of benzothiophene derivatives.

In terms of pharmacological activity, 5-Fluoro-1-benzothiophene-2-carboxamide has shown promising results in preclinical studies. It exhibits potent anti-inflammatory and antioxidant properties, making it a potential candidate for treating conditions such as neurodegenerative diseases and cardiovascular disorders. Additionally, this compound has demonstrated selective inhibition against certain enzymes, highlighting its potential as a lead molecule in drug discovery.

Recent research has also explored the application of benzothiophene derivatives in materials science. The unique electronic properties of these compounds make them suitable for use in organic electronics, such as field-effect transistors (FETs) and light-emitting diodes (LEDs). Studies have shown that incorporating fluorine atoms into the benzothiophene framework can enhance charge transport properties, which is critical for improving device performance.

The development of novel synthetic strategies for 5-Fluoro-1-benzothiophene-2-carboxamide has been a focal point of recent investigations. For example, researchers have utilized microwave-assisted synthesis to accelerate reaction times while maintaining high yields. Such innovations not only streamline production but also reduce environmental impact by minimizing waste generation.

In conclusion, 5-Fluoro-1-benzothiophene-2-carboxamide represents a compelling example of how structural modifications can significantly influence the properties and applications of benzothiophene derivatives. With ongoing advancements in synthetic methodologies and pharmacological research, this compound holds immense potential across diverse fields. As scientists continue to explore its capabilities, we can anticipate exciting breakthroughs that will further solidify its importance in modern chemistry and beyond.

• 211172-97-3(Benzo[b]thiophene-2-carboxamide, N-hydroxy-)
• 1098356-00-3(5-fluoro-1-benzothiophene-2-carbohydrazide)
• 1098351-44-0(4-Fluoro-1-benzothiophene-2-carbohydrazide)
• 1956371-69-9(7-Fluoro-1-benzothiophene-2-carboxamide)
• 335032-44-5(N-Methyl benzothiophene-2-carboxamide)
• 6314-42-7(1-Benzothiophene-2-carboxamide)
• 743367-01-3(Benzo[b]thiophene-2-methanamine, 5-fluoro-)
• 698367-29-2(5-Fluoro-1-benzothiophene-2-carbaldehyde)
• 1048913-86-5(7-Fluoro-1-benzothiophene-2-carbohydrazide)
• 866018-22-6(Benzo[b]thiophene-2-carboxamide, 4-fluoro-N-(phenylmethyl)-)