• 1. Metallation of pyridine N-oxides and application to synthesis
  Olivier Mongin,Patrick Rocca,Laurence Thomas-dit-Dumont,Fran?ois Trécourt,Francis Marsais,Alain Godard,Guy Quéguiner J. Chem. Soc. Perkin Trans. 1 1995 2503
• 2. Slow magnetic relaxation in penta-coordinate cobalt(ii) field-induced single-ion magnets (SIMs) with easy-axis magnetic anisotropy
  Salah S. Massoud,Zoe E. Perez,Jessica R. Courson,Roland C. Fischer,Franz A. Mautner,Ján Van?o,Michal ?ajan,Zdeněk Trávní?ek Dalton Trans. 2020 49 11715
• 3. Prescribed drugs containing nitrogen heterocycles: an overview
  Majid M. Heravi,Vahideh Zadsirjan RSC Adv. 2020 10 44247
• 4. Synthesis and biological activities of novel trifluoromethylpyridine amide derivatives containing sulfur moieties
  S. X. Guo,F. He,A. L. Dai,R. F. Zhang,S. H. Chen,J. Wu RSC Adv. 2020 10 35658
• 5. Identification of potent anticancer copper(ii) complexes containing tripodal bis[2-ethyl-di(3,5-dialkyl-1H-pyrazol-1-yl)]amine moiety
  Salah S. Massoud,Febee R. Louka,Madison T. Dial,Andrew J. Malek,Roland C. Fischer,Franz A. Mautner,Ján Van?o,Tomá? Malina,Zdeněk Dvo?ák,Zdeněk Trávní?ek Dalton Trans. 2021 50 11521

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Alkyl aryl ethers

Professional Introduction to 3,4-Dimethoxypyridine (CAS No. 109613-93-6)

3,4-Dimethoxypyridine, identified by the Chemical Abstracts Service Number (CAS No.) 109613-93-6, is a significant heterocyclic organic compound that has garnered considerable attention in the field of pharmaceutical chemistry and materials science. This compound, featuring a pyridine core substituted with two methoxy groups at the 3rd and 4th positions, exhibits unique electronic and steric properties that make it a valuable intermediate in synthetic chemistry. Its molecular structure not only contributes to its reactivity but also influences its potential applications in drug development and industrial processes.

The utility of 3,4-dimethoxypyridine stems from its ability to serve as a versatile building block in the synthesis of more complex molecules. The methoxy groups provide sites for further functionalization, enabling chemists to tailor the compound for specific applications. In recent years, researchers have explored its role in the development of novel pharmaceuticals, where it acts as a key scaffold for designing molecules with enhanced biological activity. The pyridine ring itself is a common motif in many bioactive compounds, and modifications at the 3 and 4 positions can significantly alter pharmacokinetic properties.

One of the most compelling aspects of 3,4-dimethoxypyridine is its application in medicinal chemistry. The compound has been investigated for its potential as an intermediate in the synthesis of kinase inhibitors, which are crucial in treating various cancers and inflammatory diseases. The electron-rich nature of the methoxy-substituted pyridine ring allows for interactions with metal ions, making it an attractive candidate for designing coordination complexes with therapeutic potential. These complexes have shown promise in preclinical studies for their ability to modulate enzyme activity and inhibit disease progression.

Recent advancements in computational chemistry have further highlighted the importance of 3,4-dimethoxypyridine in drug discovery. Molecular modeling studies indicate that this compound can effectively engage with biological targets through hydrogen bonding and π-stacking interactions. Such insights have guided the design of next-generation drugs that incorporate 3,4-dimethoxypyridine as a core structural element. The compound's stability under various reaction conditions also makes it a reliable choice for multi-step synthetic routes, ensuring high yields and purity in pharmaceutical production.

Beyond pharmaceutical applications, 3,4-dimethoxypyridine has found utility in materials science. Its electronic properties make it suitable for use in organic electronics, where it can contribute to the development of more efficient light-emitting diodes (LEDs) and photovoltaic cells. The methoxy groups on the pyridine ring can also enhance solubility, facilitating its incorporation into polymer matrices for advanced material formulations. These applications underscore the compound's broad industrial relevance beyond traditional chemical synthesis.

The synthesis of 3,4-dimethoxypyridine (CAS No. 109613-93-6) typically involves multi-step organic reactions that require precise control over reaction conditions. Common synthetic pathways include nucleophilic substitution reactions on halogenated pyridines or condensation reactions involving appropriately substituted precursors. Advances in green chemistry have also led to more sustainable methods for producing this compound, emphasizing minimal waste generation and energy efficiency. Such innovations align with global efforts to reduce the environmental impact of chemical manufacturing.

In conclusion, 3,4-dimethoxypyridine represents a fascinating example of how structural modifications can yield compounds with diverse applications. Its role in pharmaceutical development continues to evolve with new research findings, while its potential in materials science opens up exciting avenues for future exploration. As our understanding of molecular interactions deepens, compounds like 3,4-dimethoxypyridine will undoubtedly remain at the forefront of innovation across multiple scientific disciplines.

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• 2176-45-6(3-Phenoxypyridine)
• 105935-07-7(3,4-dimethoxy-1H-Pyrrole)
• 7295-76-3(3-Methoxypyridine)
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• 95907-05-4(2-Pyridinol, 3-methoxy-)
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