• 1. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 2. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 3. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644
• 4. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
• 5. An amplified fluorescence detection of T4 polynucleotide kinase activity based on coupled exonuclease III reaction and a graphene oxide platform?
  Ni-Na Sun,Fengli Qu,Xiaobing Zhang,Shufang Zhang,Jinmao You Analyst, 2015,140, 1827-1831

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Aralkylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Aralkylamines

Comprehensive Overview of 1-(5-fluoropyridin-3-yl)methylpiperazine (CAS No. 1095380-87-2): Properties, Applications, and Industry Insights

1-(5-fluoropyridin-3-yl)methylpiperazine (CAS No. 1095380-87-2) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This fluorinated piperazine derivative is characterized by its unique molecular structure, combining a fluoropyridine moiety with a methylpiperazine group. Such structural features make it a valuable intermediate in the synthesis of bioactive molecules, particularly in the development of targeted therapies and small-molecule drugs.

The compound’s 5-fluoropyridin-3-yl component is a critical functional group, often associated with enhanced binding affinity in drug-receptor interactions. Researchers have explored its potential in modulating central nervous system (CNS) targets, given the piperazine ring’s prevalence in neuroactive compounds. Recent studies highlight its relevance in kinase inhibition and GPCR modulation, aligning with the growing demand for precision medicine. Notably, its fluorine atom contributes to improved metabolic stability, a key consideration in modern drug design.

In agrochemical applications, 1-(5-fluoropyridin-3-yl)methylpiperazine serves as a precursor for crop protection agents. Its fluorinated structure enhances pesticidal activity while minimizing environmental persistence, addressing the industry’s shift toward sustainable chemistry. This dual utility in pharmaceuticals and agrochemicals underscores its versatility, making it a focal point for patent filings and R&D investments.

From a synthetic perspective, the compound’s CAS No. 1095380-87-2 is frequently cited in process optimization literature. Innovations in catalytic fluorination and green chemistry have streamlined its production, reducing reliance on hazardous reagents. These advancements resonate with the broader push for ESG compliance in chemical manufacturing, a topic dominating industry forums and investor discussions.

Market analysts note rising demand for fluorinated building blocks like 1-(5-fluoropyridin-3-yl)methylpiperazine, driven by the expansion of biotech startups and generic drug pipelines. Regulatory agencies emphasize thorough impurity profiling for such intermediates, reflecting stricter quality-by-design (QbD) standards. These trends are frequently queried in search engines, with professionals seeking data on scalable synthesis and ICH guidelines compliance.

In conclusion, 1-(5-fluoropyridin-3-yl)methylpiperazine exemplifies the intersection of medicinal chemistry and industrial innovation. Its applications span life sciences and material engineering, with ongoing research exploring its role in next-generation therapeutics. As the scientific community prioritizes structure-activity relationships (SAR) and computational modeling, this compound remains a benchmark for rational drug design.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)