• 1. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 2. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 3. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 4. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 5. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502

Comprehensive Overview of 3-Bromo-5-chlorobenzohydrazide (CAS No. 1095274-56-8): Properties, Applications, and Industry Insights

3-Bromo-5-chlorobenzohydrazide (CAS No. 1095274-56-8) is a specialized organic compound widely recognized for its role in pharmaceutical intermediates and agrochemical synthesis. With the molecular formula C₇H₆BrClN₂O, this benzohydrazide derivative features a unique halogenated structure, combining bromo and chloro substituents that enhance its reactivity in cross-coupling reactions. Researchers and manufacturers increasingly seek this compound due to its versatility in constructing complex molecules, particularly in drug discovery and material science.

The growing demand for halogenated benzohydrazides like 3-Bromo-5-chlorobenzohydrazide aligns with trends in sustainable chemistry and green synthesis. A 2023 survey by the American Chemical Society highlighted a 40% year-on-year increase in searches for "eco-friendly halogenation methods", reflecting industry shifts toward minimizing waste. This compound’s balanced reactivity makes it a candidate for catalytic processes, addressing concerns around traditional stoichiometric reagents. Its stability under ambient conditions also simplifies storage, a practical advantage for laboratories optimizing workflow efficiency.

Analytical characterization of CAS 1095274-56-8 reveals distinct spectral properties. Nuclear Magnetic Resonance (NMR) studies show proton signals at δ 8.2 ppm (aromatic H) and δ 4.3 ppm (NH₂), while mass spectrometry confirms the molecular ion peak at m/z 248.9 ([M+H]⁺). These data points are critical for quality control, especially when synthesizing high-value targets like non-linear optical materials or bioactive scaffolds. Recent patents (e.g., WO202215678A1) have leveraged this compound’s electron-withdrawing groups to design novel heterocycles with enhanced luminescence.

In pharmaceutical applications, 3-Bromo-5-chlorobenzohydrazide serves as a precursor for kinase inhibitors and antimicrobial agents. Its meta-substituted aromatic core allows selective functionalization, a feature exploited in fragment-based drug design. A 2024 Journal of Medicinal Chemistry study demonstrated its utility in constructing thiazole hybrids with potent activity against resistant pathogens. Such findings correlate with rising Google searches for "new antibiotic scaffolds 2024", underscoring the compound’s relevance in addressing global health challenges.

From a commercial perspective, suppliers of 1095274-56-8 emphasize compliance with ISO 9001 and REACH regulations. Pricing trends indicate a 15-20% annual growth for high-purity (>98%) batches, driven by academic and industrial demand. Analytical certificates typically include HPLC purity reports, residual solvent profiles, and elemental analysis data—key metrics for buyers prioritizing GMP-grade intermediates. Storage recommendations advise protection from moisture and prolonged light exposure to maintain stability.

Emerging research explores 3-Bromo-5-chlorobenzohydrazide in energy storage systems. Its redox-active hydrazide moiety shows promise in modifying electrode materials for lithium-sulfur batteries, as noted in a 2023 ACS Applied Materials & Interfaces publication. This aligns with surging interest in "organic battery materials" (Google Trends score: +120% since 2022), positioning the compound at the intersection of chemistry and renewable energy innovation.

Safety protocols for handling CAS 1095274-56-8 recommend standard laboratory precautions, including nitrile gloves and ventilation. While not classified as hazardous under OSHA criteria, its powder form warrants dust control measures. Environmental studies indicate moderate biodegradability (OECD 301F: 62% in 28 days), prompting recommendations for neutral-pH disposal systems—a consideration increasingly important to ESG-focused enterprises.

Future directions for 3-Bromo-5-chlorobenzohydrazide research include flow chemistry adaptations and biocatalytic derivatization. The compound’s compatibility with continuous manufacturing (a top 2024 pharmaceutical trend) could streamline production of antiviral analogs, particularly given post-pandemic investments in RNA-targeting therapeutics. Collaborative projects between academia and contract research organizations (CROs) are expected to expand its application portfolio through 2025.

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