• 1. Emerging investigators
  Polym. Chem., 2015,6, 5501-5502
• 2. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 5. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

Comprehensive Overview of N-ethyl-2-fluorobenzene-1-sulfonamide (CAS No. 1094523-56-4)

N-ethyl-2-fluorobenzene-1-sulfonamide (CAS No. 1094523-56-4) is a specialized sulfonamide derivative with significant applications in pharmaceutical and agrochemical research. This compound, characterized by its fluorinated aromatic ring and ethyl-substituted sulfonamide group, has garnered attention for its potential in drug discovery and material science. Researchers are increasingly exploring its role as a building block for bioactive molecules, particularly in the development of enzyme inhibitors and receptor modulators.

The structural uniqueness of N-ethyl-2-fluorobenzene-1-sulfonamide lies in its electron-withdrawing fluorine atom, which enhances the compound's reactivity and binding affinity. This feature aligns with current trends in precision chemistry, where fluorinated compounds are prized for their metabolic stability and bioavailability. Recent studies highlight its utility in medicinal chemistry, especially in designing targeted therapies for chronic diseases—a topic frequently searched in AI-driven drug development platforms.

From a synthetic perspective, CAS 1094523-56-4 serves as a versatile intermediate. Its sulfonamide moiety allows for facile derivatization, making it valuable for high-throughput screening libraries. Industry professionals often inquire about its scalable synthesis methods, reflecting the growing demand for cost-effective intermediates in green chemistry initiatives. Optimized routes using catalytic fluorination techniques have been documented, addressing sustainability concerns—a key focus in modern chemical manufacturing forums.

The compound's physicochemical properties, including its lipophilicity (LogP) and hydrogen-bonding capacity, are frequently analyzed in QSAR modeling studies. These parameters are critical for drug-likeness predictions, a hot topic in computational chemistry communities. Notably, its thermal stability (>200°C) makes it suitable for high-temperature reactions, a feature often queried in process chemistry discussions.

In material science, N-ethyl-2-fluorobenzene-1-sulfonamide has shown promise in polymeric applications. Its ability to modify surface properties of polymers aligns with searches for advanced coating materials. Patent literature reveals its use in ion-conductive membranes for energy storage devices—an area exploding in renewable energy research. This dual applicability in life sciences and advanced materials underscores its interdisciplinary relevance.

Analytical characterization of CAS 1094523-56-4 typically involves HPLC purity analysis (>98%) and spectroscopic techniques (NMR, IR, MS). These protocols are commonly searched by quality control specialists. Recent advancements in benchtop NMR have streamlined its identification, reflecting the industry's shift toward decentralized analytics—a trend dominating lab equipment forums.

Regulatory-wise, this compound falls under standard laboratory safety protocols. While not classified as hazardous, proper PPE guidelines (gloves, goggles) are recommended—a frequently asked topic in EHS databases. Its non-hygroscopic nature simplifies storage, often discussed in chemical inventory management systems.

The commercial availability of N-ethyl-2-fluorobenzene-1-sulfonamide through specialty chemical suppliers has expanded, driven by its rising R&D demand. Procurement queries often focus on bulk pricing and custom synthesis options—key metrics in procurement optimization strategies. Suppliers increasingly provide technical datasheets with structure-activity relationship data, catering to bioinformatics-driven research.

Future prospects for 1094523-56-4 include explorations in bioconjugation chemistry and proteolysis-targeting chimeras (PROTACs)—cutting-edge areas in degradation therapeutics. These applications resonate with trending searches in next-gen therapeutics, positioning this compound as a future-forward intermediate in the chemical innovation landscape.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)