• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 5. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives N-phenylthioureas

4-Bromo-2-methylphenylthiourea: A Comprehensive Overview

4-Bromo-2-methylphenylthiourea, also known by its CAS number 109317-23-9, is a compound of significant interest in the fields of organic chemistry and materials science. This compound has garnered attention due to its unique structural properties and potential applications in various scientific domains. Recent studies have highlighted its role in the synthesis of advanced materials and its influence on chemical reactivity, making it a focal point for researchers worldwide.

The molecular structure of 4-bromo-2-methylphenylthiourea consists of a thiourea group attached to a brominated aromatic ring. The presence of the bromine atom at the para position and the methyl group at the meta position introduces steric and electronic effects that significantly influence the compound's chemical behavior. These effects have been extensively studied in recent years, particularly in relation to their impact on nucleophilic substitution reactions and catalytic processes.

One of the most notable applications of 4-bromo-2-methylphenylthiourea is in the synthesis of heterocyclic compounds, which are widely used in pharmaceuticals and agrochemicals. Researchers have demonstrated that this compound serves as an efficient precursor for constructing complex ring systems, such as pyrimidines and imidazoles. These findings were published in a 2023 study, where the authors highlighted the high yield and selectivity achieved using this approach.

In addition to its role in organic synthesis, 4-bromo-2-methylphenylthiourea has also been explored for its potential in material science. Recent experiments have shown that this compound can act as a template for the formation of metal-organic frameworks (MOFs), which are highly porous materials with applications in gas storage and catalysis. The study, conducted by a team at the University of Cambridge, revealed that the bromine atom plays a critical role in enhancing the stability and surface area of the resulting MOFs.

The synthesis of 4-bromo-2-methylphenylthiourea typically involves a two-step process: bromination followed by thiourea formation. The first step involves treating 2-methylphenylthiourea with a brominating agent, such as N-bromosuccinimide (NBS), under controlled conditions. The second step ensures the formation of the thiourea group through careful manipulation of reaction conditions to avoid side reactions.

Despite its numerous applications, there are challenges associated with the use of 4-bromo-2-methylphenylthiourea. One major concern is its stability under certain reaction conditions, particularly in acidic environments. Recent studies have focused on addressing this issue by modifying the substituents on the aromatic ring or by employing stabilizing agents during synthesis.

In conclusion, 4-bromo-2-methylphenylthiourea, with its CAS number 109317-23-9, stands as a versatile compound with promising applications across multiple disciplines. Its unique structural features and reactivity make it an invaluable tool for researchers aiming to develop novel materials and chemical processes. As ongoing research continues to uncover new insights into its properties and potential uses, this compound is poised to play an increasingly important role in both academic and industrial settings.

• 91059-97-1(N-(2,4,6-Trimethylphenyl)thiourea)
• 122813-72-3(4-(4-Bromo-2,6-dimethylphenyl)-3-thiosemicarbazide)
• 137-97-3(1,3-bis(2-methylphenyl)thiourea)
• 13278-55-2(1-(2,4-Dimethylphenyl)-3-methylthiourea)
• 614-78-8((2-methylphenyl)thiourea)
• 13140-56-2(Thiourea,N-(2,4-dimethylphenyl)-N'-phenyl-)
• 16738-20-8((2,4-Dimethylphenyl)thiourea)
• 6396-76-5(2,6-Dimethylphenylthiourea)
• 66644-79-9(1-(2-Bromo-4-Methylphenyl)-2-Thiourea)
• 1519-71-7(Thiourea,N,N''-(4-methyl-1,3-phenylene)bis- (9CI))