• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 3. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 4. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 5. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

Introduction to 5-Iodo-2-methylpyridine-3-carboxylic acid (CAS No. 1092286-33-3)

5-Iodo-2-methylpyridine-3-carboxylic acid is a significant compound in the realm of pharmaceutical and chemical synthesis, characterized by its unique structural properties and versatile applications. This compound, identified by the CAS number 1092286-33-3, has garnered attention in recent years due to its role as a key intermediate in the development of various bioactive molecules. The presence of both an iodine substituent and a carboxylic acid group makes it a valuable building block for medicinal chemists and synthetic organic chemists alike.

The molecular structure of 5-Iodo-2-methylpyridine-3-carboxylic acid consists of a pyridine core, which is a six-membered aromatic heterocycle containing one nitrogen atom. This nitrogen atom is essential for the compound's reactivity and its ability to participate in various chemical transformations. The iodo group at the 5-position and the methyl group at the 2-position contribute to the compound's distinct electronic and steric properties, influencing its behavior in synthetic reactions.

In recent years, there has been a growing interest in the applications of 5-Iodo-2-methylpyridine-3-carboxylic acid in drug discovery and development. Its iodine moiety, in particular, makes it a suitable candidate for cross-coupling reactions such as Suzuki-Miyaura and Stille couplings, which are widely used in constructing complex organic molecules. These reactions are pivotal in the synthesis of pharmaceuticals, agrochemicals, and materials science products.

One of the most notable applications of 5-Iodo-2-methylpyridine-3-carboxylic acid is in the synthesis of biologically active compounds. For instance, researchers have utilized this compound to develop novel pyridine-based derivatives with potential therapeutic effects. These derivatives have shown promise in preclinical studies as inhibitors of various enzymes and receptors involved in diseases such as cancer, inflammation, and neurodegenerative disorders. The carboxylic acid group at the 3-position further enhances its utility by allowing for further functionalization through esterification or amidation reactions.

The synthesis of 5-Iodo-2-methylpyridine-3-carboxylic acid typically involves multi-step organic transformations starting from readily available pyridine precursors. The introduction of the iodine substituent often requires halogenation techniques, while the methylation at the 2-position can be achieved through various alkylating agents. The final step involves carboxylation to introduce the carboxylic acid functionality. These synthetic routes highlight the compound's importance as a versatile intermediate in organic synthesis.

Recent advancements in catalytic methods have further improved the efficiency of synthesizing 5-Iodo-2-methylpyridine-3-carboxylic acid. Transition metal-catalyzed reactions, for example, have enabled more selective and milder conditions for introducing functional groups into the pyridine ring. Such improvements not only enhance yield but also reduce waste, aligning with green chemistry principles.

The pharmacological potential of derivatives derived from 5-Iodo-2-methylpyridine-3-carboxylic acid has been explored extensively. Studies have demonstrated that modifications at different positions on the pyridine ring can significantly alter the biological activity of these compounds. For instance, replacing the iodine atom with other halogens or introducing additional heterocycles has led to compounds with enhanced binding affinity to target proteins. This flexibility underscores the importance of 5-Iodo-2-methylpyridine-3-carboxylic acid as a scaffold for drug discovery.

Another area where 5-Iodo-2-methylpyridine-3-carboxylic acid has found utility is in materials science. Its ability to participate in cross-coupling reactions makes it a valuable precursor for synthesizing organic electronic materials such as conductive polymers and light-emitting diodes (LEDs). These materials are crucial for developing next-generation electronic devices with improved performance and efficiency.

The chemical reactivity of 5-Iodo-2-methylpyridine-3-carboxylic acid also makes it useful in polymer chemistry. Researchers have employed this compound to develop novel polymers with tailored properties such as biodegradability, biocompatibility, and mechanical strength. These polymers have potential applications in medical implants, drug delivery systems, and sustainable packaging materials.

In conclusion, 5-Iodo-2-methylpyridine-3-carboxylic acid (CAS No. 1092286-33-3) is a multifaceted compound with significant applications across pharmaceuticals, materials science, and polymer chemistry. Its unique structural features enable diverse chemical transformations, making it an indispensable tool for synthetic chemists and researchers working on drug discovery and development. As research continues to uncover new applications for this compound, its importance is likely to grow even further.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)