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2-Ketoglutaric Acid-13C1: A Comprehensive Overview

The compound 2-Ketoglutaric Acid-13C1 (CAS No. 108395-15-9) is a stable isotope-labeled version of 2-ketoglutaric acid, a naturally occurring compound that plays a pivotal role in various biochemical pathways. This compound is widely utilized in research, particularly in the fields of metabolism, biochemistry, and molecular biology. The incorporation of the 13C isotope allows researchers to track and analyze metabolic processes with unprecedented precision, making it an invaluable tool in modern scientific studies.

Structure and Properties: 2-Ketoglutaric acid is a dicarboxylic acid with the molecular formula C5H6O5. The 13C1 label is introduced at the second carbon position, creating a unique isotopic signature that distinguishes it from the natural abundance counterpart. This labeling does not alter the chemical properties of the compound but provides a means for tracing its movement through biological systems. The compound is stable under normal storage conditions and exhibits good solubility in water, making it suitable for a wide range of experimental applications.

Applications in Research: The use of 2-Ketoglutaric Acid-13C1 has become increasingly popular in metabolic studies due to its ability to serve as a tracer in metabolic flux analysis. Researchers employ this compound to study the dynamics of the tricarboxylic acid (TCA) cycle, a central metabolic pathway responsible for energy production and biosynthesis. By incorporating 2-Ketoglutaric Acid-13C1 into cell cultures or animal models, scientists can monitor the flow of carbon through metabolic pathways, providing insights into cellular energetics and regulatory mechanisms.

Recent Research Findings: Recent studies have highlighted the role of 2-Ketoglutaric Acid-13C1 in understanding metabolic adaptations under various physiological conditions. For instance, researchers have used this compound to investigate the metabolic reprogramming that occurs during cancer progression. By tracing the fate of 2-Ketoglutaric Acid-13C1, scientists have identified key regulatory nodes that could serve as therapeutic targets for cancer treatment.

In addition to its role in basic research, 2-Ketoglutaric Acid-13C1 has found applications in biotechnology and drug discovery. Its use in fermentation processes has enabled researchers to optimize microbial metabolism for the production of valuable biochemicals. Furthermore, this compound has been employed in pharmacokinetic studies to assess drug metabolism and bioavailability, contributing to the development of safer and more effective medications.

Advantages Over Traditional Methods: The use of 2-Ketoglutaric Acid-13C1 offers several advantages over traditional methods for studying metabolism. Unlike radioactive tracers, which pose safety risks and require specialized handling procedures, stable isotopes like 2-Ketoglutaric Acid-13C1 are non-hazardous and can be used safely in both laboratory and clinical settings. Additionally, the isotopic signature provided by 2-Ketoglutaric Acid-13C

• 1821-02-9(2-Oxovaleric Acid)
• 3184-35-8(Hexanedioic acid,2-oxo-)
• 816-66-0(4-Methyl-2-oxovaleric Acid)
• 328-51-8(Octanoic acid, 2-oxo-)
• 17126-90-8(2-Oxoheptanedioic Acid)
• 328-50-7(2-Ketoglutaric acid)
• 997-43-3(2-Ketoglutaric Acid Monopotassium Salt)
• 600-18-0(a-Ketobutyric Acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)