Cas no 108288-16-0 (2-Amino-4-chloro-5-fluorobenzoic acid)
2-Amino-4-chloro-5-fluorobenzoic acid is a fluorinated benzoic acid derivative featuring both amino and chloro substituents, making it a versatile intermediate in pharmaceutical and agrochemical synthesis. Its distinct substitution pattern enables selective functionalization, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. The presence of fluorine enhances metabolic stability and bioavailability, while the amino group allows for further derivatization via amidation or coupling reactions. This compound is particularly valuable in medicinal chemistry for constructing heterocyclic scaffolds. High purity grades are available to meet stringent research and industrial requirements, ensuring reproducibility in synthetic applications. Proper handling is advised due to its reactive functional groups.
108288-16-0 structure
Product Name:2-Amino-4-chloro-5-fluorobenzoic acid
CAS No:108288-16-0
MF:C7H5ClFNO2
MW:189.571504354477
MDL:MFCD05664859
CID:97306
PubChem ID:14668145
Update Time:2025-06-10
2-Amino-4-chloro-5-fluorobenzoic acid Chemical and Physical Properties
Names and Identifiers
-
- 2-Amino-4-chloro-5-fluorobenzoic acid
- Benzoic acid, 2-amino-4-chloro-5-fluoro-
- 2-amino-4-chloro-5-fluoro-benzoic acid
- 4-chloro-5-fluoroanthranilic acid
- ACMC-20a7tf
- AGN-PC-002BHR
- ANW-61057
- CL9060
- CTK0G2761
- SureCN1096218
- BENZOIC ACID,2-AMINO-4-CHLORO-5-FLUORO-
- FCH850196
- AM83212
- AX8215128
- AB0065280
- Z3871
- ST24021962
- BB 0261448
- 2-amino-4-chloro-5-fluo
- 2-amino-4-chloro-5-fluorobenzoic acid, Aldric
- 108288-16-0
- A848156
- AKOS006292975
- DS-15621
- SY002460
- FT-0696520
- SCHEMBL1096218
- MFCD05664859
- CS-W005711
- DTXSID70562807
- SB30520
- 2-amino-4-chloro-5-fluorobenzoic acid, AldrichCPR
- 2-Amino-4-chloro-5-fluorobenzoicacid
- DB-346736
-
- MDL： MFCD05664859
- Inchi： 1S/C7H5ClFNO2/c8-4-2-6(10)3(7(11)12)1-5(4)9/h1-2H,10H2,(H,11,12)
- InChI Key： NGCSJYVKMMNJIJ-UHFFFAOYSA-N
- SMILES： ClC1C(=CC(C(=O)O)=C(C=1)N)F
Computed Properties
- Exact Mass: 188.99935
- Monoisotopic Mass: 188.9992843g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 12
- Rotatable Bond Count: 1
- Complexity: 190
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 63.3
- XLogP3: 2
Experimental Properties
- Color/Form: No data avaiable
- Density: 1.6±0.1 g/cm3
- Melting Point: No data available
- Boiling Point: 350.1℃ at 760 mmHg
- Flash Point: 144.4±23.7 °C
- PSA: 63.32
- LogP: 2.34070
- Vapor Pressure: 0.0±0.7 mmHg at 25°C
2-Amino-4-chloro-5-fluorobenzoic acid Security Information
- Signal Word：warning
- Hazard Statement： H303+H313+H333
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - Safety Instruction： H303+H313+H333
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
2-Amino-4-chloro-5-fluorobenzoic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | A842117-1g |
2-Amino-4-chloro-5-fluorobenzoic acid |
108288-16-0 | 98% | 1g |
540.90 | 2021-05-17 | |
| Fluorochem | 224045-250mg |
2-Amino-4-chloro-5-fluorobenzoic acid |
108288-16-0 | 95% | 250mg |
￡25.00 | 2022-02-28 | |
| Fluorochem | 224045-1g |
2-Amino-4-chloro-5-fluorobenzoic acid |
108288-16-0 | 95% | 1g |
￡56.00 | 2022-02-28 | |
| Fluorochem | 224045-5g |
2-Amino-4-chloro-5-fluorobenzoic acid |
108288-16-0 | 95% | 5g |
￡168.00 | 2022-02-28 | |
| Fluorochem | 224045-10g |
2-Amino-4-chloro-5-fluorobenzoic acid |
108288-16-0 | 95% | 10g |
￡281.00 | 2022-02-28 | |
| ChemScence | CS-W005711-1g |
2-Amino-4-chloro-5-fluorobenzoic acid |
108288-16-0 | 99.49% | 1g |
$63.0 | 2022-04-28 | |
| ChemScence | CS-W005711-5g |
2-Amino-4-chloro-5-fluorobenzoic acid |
108288-16-0 | 99.49% | 5g |
$196.0 | 2022-04-28 | |
| ChemScence | CS-W005711-10g |
2-Amino-4-chloro-5-fluorobenzoic acid |
108288-16-0 | 99.49% | 10g |
$354.0 | 2022-04-28 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A189616-10g |
2-Amino-4-chloro-5-fluorobenzoic acid |
108288-16-0 | 98% | 10g |
￥2209.90 | 2023-09-04 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A189616-1g |
2-Amino-4-chloro-5-fluorobenzoic acid |
108288-16-0 | 98% | 1g |
￥392.90 | 2023-09-04 |
2-Amino-4-chloro-5-fluorobenzoic acid Related Literature
-
Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
-
Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
-
Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
-
Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
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