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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Styrenes

Introduction to 2,3-Difluorostyrene (CAS No. 1080636-91-4)

2,3-Difluorostyrene (CAS No. 1080636-91-4) is a versatile organic compound that has gained significant attention in recent years due to its unique chemical properties and potential applications in various fields, including pharmaceuticals, materials science, and chemical synthesis. This compound is characterized by its molecular structure, which consists of a styrene backbone with fluorine atoms substituted at the 2 and 3 positions. The presence of these fluorine atoms imparts distinct physical and chemical properties to the molecule, making it a valuable building block in the synthesis of advanced materials and pharmaceutical intermediates.

The molecular formula of 2,3-Difluorostyrene is C₈H₆F₂, and its molecular weight is approximately 144.13 g/mol. The compound is a colorless liquid at room temperature and exhibits a boiling point of around 155°C. Its solubility in organic solvents such as dichloromethane, ethyl acetate, and toluene makes it highly suitable for use in various synthetic reactions. The high electron-withdrawing nature of the fluorine atoms influences the reactivity and stability of the molecule, providing unique opportunities for chemical transformations.

In the field of pharmaceutical research, 2,3-Difluorostyrene has been explored as a key intermediate in the synthesis of several drug candidates. Fluorinated compounds are known for their enhanced metabolic stability and improved pharmacokinetic properties, which can lead to more effective and safer drugs. Recent studies have shown that derivatives of 2,3-Difluorostyrene exhibit promising biological activities, including antiviral, anticancer, and anti-inflammatory properties. For example, a study published in the Journal of Medicinal Chemistry reported the synthesis of a series of 2,3-difluorostyrene-based compounds with potent antiviral activity against influenza viruses.

Beyond pharmaceutical applications, 2,3-Difluorostyrene has also found use in materials science. The incorporation of fluorine atoms into polymers can significantly enhance their thermal stability, chemical resistance, and mechanical properties. Research in this area has led to the development of novel fluorinated polymers with applications in coatings, adhesives, and electronic devices. A notable example is the use of 2,3-difluorostyrene-based monomers in the synthesis of high-performance polymer electrolytes for lithium-ion batteries.

The synthetic versatility of 2,3-Difluorostyrene has been further demonstrated through its use in various chemical reactions. One such reaction is the Heck coupling reaction, where 2,3-difluorostyrene serves as an efficient coupling partner for the formation of complex organic molecules. This reaction has been widely used in the synthesis of natural products and pharmaceuticals due to its high selectivity and mild reaction conditions. Additionally, the Suzuki-Miyaura coupling reaction involving 2,3-difluorostyrene has been reported to produce a wide range of substituted styrenes with high yields and excellent regioselectivity.

The safety profile of 2,3-Difluorostyrene is an important consideration for its industrial and laboratory use. While it is generally considered safe when handled properly under controlled conditions, appropriate safety measures should be taken to prevent exposure to skin or inhalation. It is recommended to use personal protective equipment (PPE) such as gloves and goggles when handling this compound. Additionally, proper storage conditions should be maintained to ensure its stability and prevent degradation.

In conclusion, 2,3-Difluorostyrene (CAS No. 1080636-91-4) is a valuable compound with a wide range of applications in pharmaceuticals, materials science, and chemical synthesis. Its unique chemical properties make it an attractive building block for the development of advanced materials and drug candidates. Ongoing research continues to uncover new possibilities for this compound, highlighting its importance in modern chemistry and related fields.

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• 26838-55-1(2,3,4,5,6-Pentafluorostyrene)
• 15948-70-6(1,2,3,4,5,-Pentafluoro-6-(1e)-prop-1-en-1-ylbenzene)
• 305371-97-5(1,4-DIFLUORO-2-VINYL-BENZENE)
• 917762-06-2(Benzene, 1,4-bis[2-(2,5-difluorophenyl)ethenyl]-2,5-difluoro-)
• 653-34-9(2,3,4,5,6-Pentafluorostyrene)
• 62937-75-1(Benzene, 1,4-diethenyl-2-fluoro-)
• 106358-37-6(Benzene, pentafluoro[(1E)-2-(4-methylphenyl)ethenyl]-)
• 14992-40-6(Benzene, 1,1'-(1E)-1,2-ethenediylbis[pentafluoro-)