• 1. Synthesis of ten isomers of a macrocyclic polyether, tetramethyldibenzo-18-crown-6, and their complexes with salts of alkali metals
  David G. Parsons J. Chem. Soc. Perkin Trans. 1 1975 245
• 2. Crystal structure of tris(diethyldithioby carbamato)iridium(III)
  Colin L. Raston,Allan H. White J. Chem. Soc. Dalton Trans. 1976 32
• 3. Synthesis, properties and structures of complexes of platinum metal halides and Group 11 metals with two distibinomethane ligands, R2SbCH2SbR2 (R?=?Me or Ph)
  Tina Even,Anthony R. J. Genge,Angela M. Hill,Nicholas J. Holmes,William Levason,Michael Webster ligands R2SbCH2SbR2 (R?=?Me or Ph). Tina Even Anthony R. J. Genge Angela M. Hill Nicholas J. Holmes William Levason Michael Webster J. Chem. Soc. Dalton Trans. 2000 655
• 4. Synthesis of 2-Amino-2,5-dideoxy-5-hydroxyphosphinyl-D-mannopyranose Derivatives: New Phospho-sugar Analogues of D-Mannosamine
  Tadashi Hanaya,Yasushi Fujii,Hiroshi Yamamoto J. Chem. Res. (S) 1998 790

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Dialkyl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Dialkyl ethers
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Comprehensive Guide to Bis(1-methyl-2-hydroxyethyl) Ether (CAS No. 108-61-2): Properties, Applications, and Industry Insights

Bis(1-methyl-2-hydroxyethyl) Ether, with the CAS number 108-61-2, is a versatile chemical compound widely utilized in industrial and research applications. This diol ether, also known as 1,1'-Oxybis(2-propanol), is valued for its unique molecular structure, which combines hydroxyl and ether functional groups. Its low volatility, high solvency power, and excellent compatibility with polar and non-polar substances make it a preferred choice in formulations requiring stable performance under varying conditions.

In recent years, the demand for eco-friendly solvents and green chemistry alternatives has surged, placing compounds like Bis(1-methyl-2-hydroxyethyl) Ether in the spotlight. Researchers and manufacturers are increasingly exploring its potential as a sustainable replacement for traditional solvents in coatings, adhesives, and cleaning products. Its biodegradability profile and low toxicity align with global trends toward circular economy principles and stricter environmental regulations.

The synthesis of CAS 108-61-2 typically involves the catalytic reaction of propylene oxide with water or alcohols, a process optimized for high yield and minimal byproducts. Advanced purification techniques, such as molecular distillation, ensure the final product meets stringent pharmaceutical-grade or industrial-grade specifications. Analytical methods like GC-MS and HPLC are employed to verify purity, often exceeding 99.5% for critical applications.

One of the most searched questions about Bis(1-methyl-2-hydroxyethyl) Ether relates to its role in personal care formulations. As consumers prioritize clean-label products, this compound serves as a non-irritating humectant in cosmetics, enhancing moisture retention without compromising safety. Studies confirm its dermal compatibility, making it suitable for sensitive skin formulations—a key advantage over petrochemical-derived alternatives.

In the polymer industry, 108-61-2 acts as a chain extender and crosslinking agent, improving the mechanical properties of polyurethanes and epoxy resins. Its dual functionality enables precise control over cure kinetics and thermal stability, addressing common challenges in high-performance material development. Recent patents highlight innovations in waterborne polyurethane dispersions, where this ether enhances film flexibility while reducing VOC emissions.

Emerging applications in energy storage systems have further expanded the relevance of Bis(1-methyl-2-hydroxyethyl) Ether. Electrolyte formulations for lithium-ion batteries leverage its high dielectric constant to improve ion conductivity at extreme temperatures. This aligns with the booming electric vehicle (EV) market, where battery efficiency is paramount. Concurrently, its flame-retardant synergism attracts attention for safety-enhanced energy devices.

From a regulatory standpoint, CAS 108-61-2 is listed in major chemical inventories including REACH, TSCA, and DSL, facilitating global trade. Compliance with ISO 9001 and GMP standards ensures consistent quality for pharmaceutical excipients and food-contact materials. Suppliers increasingly provide life cycle assessment (LCA) data to meet ESG reporting requirements—a growing demand among sustainability-conscious buyers.

Ongoing research explores novel derivatives of Bis(1-methyl-2-hydroxyethyl) Ether, such as acrylate-functionalized versions for UV-curable inks. These developments cater to the digital printing revolution, where fast-curing, low-migration materials are essential. Similarly, its chelating ability shows promise in wastewater treatment systems, particularly for heavy metal sequestration—a critical need in mining and electronics manufacturing.

For laboratory users, proper handling of 108-61-2 involves standard organic chemical precautions. While not classified as hazardous under GHS criteria, recommendations include ventilated storage and PPE like nitrile gloves. Technical bulletins emphasize its hygroscopic nature, advising nitrogen blanketing during long-term storage to maintain purity—a frequent query from quality control professionals.

The market outlook for Bis(1-methyl-2-hydroxyethyl) Ether remains positive, with CAGR projections of 4-6% through 2030. Growth drivers include bio-based polymer expansion and electronics miniaturization trends. Strategic partnerships between specialty chemical producers and end-user industries are accelerating product innovation, particularly in Asia-Pacific markets where industrial output continues to rise.

• 104562-43-8(1-propanol, 2-(2-ethoxyethoxy)-)
• 5405-87-8(1-{2-[(1-ethoxypropan-2-yl)oxy]propoxy}propan-2-ol)
• 19089-47-5(2-ethoxypropan-1-ol)
• 74198-19-9(2,5,8,11-Tetraoxatridecan-13-ol,12-methyl-)
• 58797-30-1(1-(2-Ethoxy-1-methylethoxy)-2-propanol)
• 139720-95-9(1-Propanol, 2-[2-(2-hydroxyethoxy)ethoxy]-)
• 116646-26-5(1-methoxy-2-[2-[2-(2-methoxypropoxy)propoxy]propoxy]propane)
• 3944-37-4(1-Propanol,2-(1-methylethoxy)-)
• 101209-83-0(1-propanol, 2-(2-methoxyethoxy)-)
• 38432-09-6(1-Propanol, 2-(2-hydroxyethoxy)-)