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  Roberto Fernández-Maestre,Charles Steve Harden,Robert Gordon Ewing,Christina Lynn Crawford,Herbert Henderson Hill Analyst 2010 135 1433
• 2. The synthesis of a series of adenosine A3 receptor agonists
  Kenneth J. Broadley,Erica Burnell,Robin H. Davies,Alan T. L. Lee,Stephen Snee,Eric J. Thomas Org. Biomol. Chem. 2016 14 3765
• 3. Calibration of the mobility scale in ion mobility spectrometry: the use of 2,4-lutidine as a chemical standard, the two-standard calibration method and the incorrect use of drift tube temperature for calibration
  Roberto Fernández Maestre Anal. Methods 2017 9 4288
• 4. Cocrystallisation of succinic and fumaric acids with lutidines: a systematic study
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Methylpyridines
• Pharmaceutical and Biochemical Products Medicinal Building Blocks Heterocyclic Building Blocks
• Solvents and Organic Chemicals Organic Compounds Heterocyclic Compounds
• Solvents and Organic Chemicals Organic Compounds

Introduction to 2,4-Lutidine (CAS No. 108-47-4)

2,4-Lutidine, chemically known as 2,4-dimethylpyridine, is a heterocyclic organic compound with the molecular formula C?H?N. This compound belongs to the pyridine family, characterized by a six-membered aromatic ring containing one nitrogen atom. With a CAS number of 108-47-4, it is widely recognized in the chemical and pharmaceutical industries due to its versatile applications and structural properties. The presence of two methyl groups at the 2- and 4-positions enhances its reactivity and makes it a valuable intermediate in synthetic chemistry.

The significance of 2,4-Lutidine lies in its role as a building block for more complex molecules. Its unique structure allows it to participate in various chemical reactions, including nucleophilic substitution, condensation reactions, and metal coordination. These properties make it indispensable in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Recent advancements in medicinal chemistry have highlighted its potential in developing novel therapeutic agents.

In the pharmaceutical sector, 2,4-Lutidine has been explored as a precursor for drugs targeting neurological disorders. Its ability to act as a ligand in metal-organic frameworks (MOFs) has also garnered attention for applications in drug delivery systems. For instance, studies have demonstrated its efficacy in stabilizing metal ions used in anticancer therapies, improving drug solubility and bioavailability. The compound’s compatibility with various functional groups allows for tailored modifications, enabling the creation of structurally diverse molecules with enhanced pharmacological profiles.

Moreover, the agrochemical industry has leveraged 2,4-Lutidine in the development of pesticides and herbicides. Its structural motif is frequently incorporated into molecules designed to interact with biological targets in pests, offering improved efficacy and reduced environmental impact. Research has shown that derivatives of 2,4-Lutidine exhibit potent insecticidal properties by disrupting essential metabolic pathways in insects.

The synthesis of 2,4-Lutidine typically involves catalytic processes that convert pyridine derivatives or other precursor compounds into the desired product. Modern synthetic methodologies have focused on optimizing yield and purity while minimizing waste generation. Green chemistry principles have been increasingly applied, utilizing renewable feedstocks and catalytic systems that enhance sustainability.

Recent studies have also explored the electronic properties of 2,4-Lutidine, particularly its utility as a ligand in organic electronics. Its ability to form stable complexes with transition metals makes it valuable in designing materials for light-emitting diodes (LEDs) and photovoltaic cells. The compound’s electron-donating nature facilitates charge transport, improving the performance of these devices.

The industrial production of 2,4-Lutidine is governed by stringent quality control measures to ensure consistency and safety. Manufacturers adhere to international standards such as ICH guidelines for pharmaceutical intermediates. The compound’s stability under various storage conditions is carefully monitored to prevent degradation and maintain its reactivity for downstream applications.

Future research directions for 2,4-Lutidine include exploring its role in biodegradable polymers and smart materials. Its incorporation into polymer backbones could lead to novel materials with enhanced mechanical strength and environmental compatibility. Additionally, its potential as a catalyst or co-catalyst in asymmetric synthesis is being investigated to develop more efficient routes for chiral drug production.

In conclusion,2,4-Lutidine (CAS No. 108-47-4) remains a cornerstone compound in synthetic chemistry due to its broad applicability across multiple industries. Its structural versatility and reactivity continue to inspire innovation in pharmaceuticals, agrochemicals, and advanced materials. As research progresses,2,4-Lutidine will undoubtedly play an integral role in shaping the future of chemical science.

• 45725-47-1(Collidine-hydrogen Fluoride Complex (approx 1:2 collidine:HF))
• 57432-26-5(4,4'-Bipyridine, 2-methyl-)
• 712-61-8(2,2'-Dimethyl-4,4'-bipyridine)
• 73850-78-9(Magnesium, (phenylmethyl)(2-pyridinylmethyl)-)
• 15032-21-0(2-methyl-4-phenylpyridine)
• 108-75-8(2,4,6-Trimethylpyridine)
• 536-88-9(4-Ethyl-2-methylpyridine)
• 102878-58-0(3,6-dimethyl-Isoquinoline)
• 20736-88-3(2,4-dimethylpyridine hydrochloride)
• 17423-08-4(2,4,6-trimethyl-Pyridine hydrochloride)