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  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylmethylamines

Comprehensive Overview of (2,6-diethoxyphenyl)methanamine hydrochloride (CAS No. 107694-31-5)

(2,6-diethoxyphenyl)methanamine hydrochloride (CAS No. 107694-31-5) is a specialized organic compound widely utilized in pharmaceutical research and fine chemical synthesis. This compound, characterized by its diethoxy-substituted phenyl core and primary amine hydrochloride functionality, has garnered significant attention due to its potential applications in drug discovery and material science. The molecular structure features a benzylamine derivative with two ethoxy groups at the ortho positions, enhancing its steric and electronic properties.

In recent years, the demand for high-purity amine derivatives like (2,6-diethoxyphenyl)methanamine hydrochloride has surged, driven by advancements in medicinal chemistry and catalysis. Researchers frequently search for "synthesis of diethoxyphenyl amines" or "applications of benzylamine derivatives," reflecting the compound's relevance in designing novel bioactive molecules. Its hydrochloride salt form improves solubility and stability, making it preferable for laboratory and industrial use.

The compound's unique structural motif enables its role as a building block for heterocyclic compounds, particularly in the development of ligands for metal-catalyzed reactions. A trending topic in organic chemistry is the exploration of sustainable synthetic routes, and 107694-31-5 has been investigated for greener preparation methods, aligning with the "green chemistry" movement. Queries such as "eco-friendly amine synthesis" highlight this focus.

Analytical techniques like NMR spectroscopy, HPLC, and mass spectrometry are critical for verifying the purity of (2,6-diethoxyphenyl)methanamine hydrochloride. Quality control is a recurring concern among purchasers, as evidenced by searches for "CAS 107694-31-5 specification" or "amine hydrochloride purity standards." Reputable suppliers provide detailed certificates of analysis (CoA) to meet these demands.

Beyond pharmaceuticals, this compound finds niche applications in agrochemicals and functional materials. Its electron-rich aromatic system makes it a candidate for designing photoactive materials, a hotspot in "organic electronics" research. Discussions on platforms like ResearchGate often center on "structure-activity relationships of substituted benzylamines," underscoring its interdisciplinary appeal.

Storage and handling of 107694-31-5 require attention to hygroscopicity, typical of hydrochloride salts. Best practices include airtight containers and desiccants, topics frequently addressed in "chemical storage guidelines" searches. While not classified as hazardous, proper laboratory safety protocols should always be followed.

In summary, (2,6-diethoxyphenyl)methanamine hydrochloride (CAS No. 107694-31-5) exemplifies the intersection of structural ingenuity and practical utility in modern chemistry. Its versatility continues to inspire innovations across multiple scientific domains, answering the growing need for tailored organic intermediates in research and industry.

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