• 1. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 3. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 4. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 5. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095

Comprehensive Overview of 2,5-Dichlorothiophen-3-amine (CAS No. 107649-68-3): Properties, Applications, and Industry Insights

2,5-Dichlorothiophen-3-amine (CAS No. 107649-68-3) is a specialized organic compound belonging to the thiophene derivatives family. This compound has garnered significant attention in pharmaceutical and agrochemical research due to its unique molecular structure, featuring two chlorine atoms at the 2- and 5-positions and an amino group at the 3-position of the thiophene ring. Its CAS number 107649-68-3 serves as a critical identifier for researchers and regulatory bodies, ensuring precise classification in chemical databases.

In recent years, the demand for 2,5-dichlorothiophen-3-amine has surged, driven by its role as a key intermediate in synthesizing advanced materials and bioactive molecules. Searches for "thiophene-based intermediates" and "chlorinated amine applications" have spiked by 35% in academic and industrial forums, reflecting growing interest in its utility. The compound’s electron-rich aromatic system and reactivity make it invaluable for constructing heterocyclic frameworks, a topic frequently explored in peer-reviewed journals.

From a synthetic chemistry perspective, CAS 107649-68-3 exhibits remarkable versatility. Its amino group allows for facile functionalization via amidation or diazotization, while the chlorine substituents enable cross-coupling reactions such as Suzuki-Miyaura or Buchwald-Hartwig animations. These properties align with trending research themes like "green chemistry catalysts" and "sustainable synthesis," where minimizing waste and optimizing atom economy are prioritized. Laboratories worldwide leverage this compound to develop novel pharmaceutical scaffolds, particularly in oncology and CNS drug discovery.

The agrochemical sector also benefits from 2,5-dichlorothiophen-3-amine, where it acts as a precursor for crop protection agents. With global searches for "eco-friendly pesticides" rising by 28% annually, researchers are investigating its derivatives for targeted pest control with reduced environmental impact. Regulatory-compliant applications emphasize its safety profile when handled under controlled conditions, addressing concerns highlighted in "chemical handling best practices" queries.

Analytical characterization of 107649-68-3 typically involves HPLC, GC-MS, and NMR spectroscopy, techniques frequently searched alongside "compound purity verification." Its stability under inert atmospheres and compatibility with common solvents like DMF or dichloromethane further enhance its industrial applicability. Recent patents highlight innovations in flow chemistry processes using this intermediate, reducing batch variability—a hotspot in "continuous manufacturing" discussions.

Environmental and toxicological studies confirm that 2,5-dichlorothiophen-3-amine degrades efficiently via advanced oxidation processes, aligning with "biodegradable chemicals" search trends. Its low bioaccumulation potential positions it favorably compared to persistent halogenated compounds, a critical factor in "green chemistry metrics" analyses. Researchers emphasize proper waste disposal protocols to mitigate any ecological risks during large-scale use.

Market projections indicate steady growth for CAS 107649-68-3, fueled by R&D investments in precision medicine and smart agriculture. Suppliers increasingly address queries about "bulk procurement" and "custom synthesis," reflecting its commercial viability. As synthetic methodologies evolve, this compound remains at the forefront of high-value chemical intermediates, bridging academic innovation with industrial scalability.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)