• 1. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 2. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 3. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 4. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 5. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Phenylpyridines

2-Amino-3-bromo-5-phenylpyridine (CAS No. 107351-80-4): A Versatile Building Block in Modern Organic Synthesis

2-Amino-3-bromo-5-phenylpyridine (CAS No. 107351-80-4) is a highly valuable heterocyclic compound that has gained significant attention in pharmaceutical research and material science. This brominated pyridine derivative serves as a crucial intermediate in the synthesis of various bioactive molecules and functional materials. With its unique molecular structure featuring both amino and bromo substituents on the pyridine ring, this compound offers exceptional reactivity for diverse chemical transformations.

The growing interest in 2-amino-3-bromo-5-phenylpyridine applications aligns with current trends in drug discovery, where researchers are actively exploring novel nitrogen-containing heterocycles for therapeutic development. Recent studies highlight its potential in creating kinase inhibitors, which are particularly relevant in cancer research - one of the most searched topics in biomedical sciences today. The compound's bromo substituent provides an excellent handle for further functionalization through cross-coupling reactions, making it valuable for medicinal chemistry applications.

From a structural perspective, 2-amino-3-bromo-5-phenylpyridine properties include a molecular weight of 249.09 g/mol and the characteristic stability of aromatic systems. The presence of both electron-donating (amino) and electron-withdrawing (bromo) groups creates interesting electronic effects that influence its chemical reactivity. These features make it particularly useful in palladium-catalyzed reactions, which remain a hot topic in synthetic chemistry as evidenced by frequent searches for "cross-coupling reactions" and "catalytic transformations" in scientific databases.

In material science applications, 2-amino-3-bromo-5-phenylpyridine synthesis has shown promise for developing novel organic electronic materials. The compound's ability to participate in π-conjugated systems makes it attractive for creating advanced materials with potential applications in OLEDs and organic semiconductors - areas experiencing rapid growth according to recent market analyses. Researchers are particularly interested in how the bromo-aminopyridine scaffold can be incorporated into larger molecular architectures for tailored electronic properties.

The safety profile of 2-amino-3-bromo-5-phenylpyridine has been well-documented in scientific literature, with standard precautions recommended for handling organic compounds in laboratory settings. Proper storage conditions typically involve protection from moisture and light at controlled temperatures. These handling considerations align with current best practices in chemical safety protocols, a topic of increasing importance in research institutions worldwide.

Market analysis shows steady demand for 2-amino-3-bromo-5-phenylpyridine suppliers, particularly from pharmaceutical and specialty chemical companies. The compound's price and availability fluctuate based on raw material costs and production scale, with current trends favoring more sustainable synthesis routes. This reflects broader industry movements toward green chemistry principles, another highly searched topic in contemporary chemical research.

Recent patents highlight innovative applications of 2-amino-3-bromo-5-phenylpyridine derivatives in various therapeutic areas, particularly in neurological disorders and inflammatory conditions. The compound's versatility as a pharmacophore building block continues to attract attention from drug discovery teams, evidenced by its inclusion in several patent applications filed in the past three years. This aligns with the pharmaceutical industry's focus on targeted therapies, one of the most discussed topics in current medical research.

Quality control for 2-amino-3-bromo-5-phenylpyridine typically involves analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry. These methods ensure the compound meets the stringent purity requirements for research and industrial applications. The importance of analytical characterization in chemical synthesis remains a persistent theme in scientific literature and educational resources, as indicated by search trends in chemistry databases.

Looking forward, the applications of 2-amino-3-bromo-5-phenylpyridine are expected to expand further as synthetic methodologies advance. The compound's unique combination of reactivity and stability positions it well for emerging areas like click chemistry and bioconjugation techniques. These fields have seen exponential growth in research interest, as shown by publication metrics and search volume data from scientific platforms.

For researchers working with 2-amino-3-bromo-5-phenylpyridine CAS 107351-80-4, current literature suggests exploring its potential in multicomponent reactions and cascade transformations. These approaches align with the pharmaceutical industry's push toward atom-efficient synthesis and reduced environmental impact. The compound's reactivity profile makes it particularly suitable for such modern synthetic strategies, which are increasingly important in both academic and industrial settings.

In conclusion, 2-amino-3-bromo-5-phenylpyridine represents a versatile and valuable compound in contemporary chemical research. Its applications span from drug discovery to advanced materials, reflecting the interdisciplinary nature of modern chemistry. As research continues to uncover new synthetic methodologies and applications, this compound is likely to maintain its importance in scientific and industrial contexts, addressing many of the current challenges and opportunities in chemical sciences.

• 17282-00-7(3-bromo-5-methylpyridin-2-amine)
• 1878106-50-3(5-(Aminomethyl)-3-bromopyridin-2-amine)
• 1381938-33-5(3-Bromo-5-(4-methoxyphenyl)-2-pyridinamine)
• 1381934-07-1(2-Amino-3-bromo-5-(2-chlorophenyl)pyridine)
• 1398636-08-2(3-(4-Aminophenyl)-5-bromopyridin-2-amine)
• 911113-30-9(3-Bromo-5-(4-trifluoromethyl-phenyl)-pyridin-2-ylamine)
• 1369347-48-7(5-(3-Bromophenyl)pyridin-2-amine)
• 1335051-77-8(5-Bromo-3-pyridin-3-ylpyridin-2-amine)
• 911113-60-5(3-Bromo-5-(4-chlorophenyl)pyridin-2-amine)
• 1381934-25-3(3-Bromo-5-ethylpyridin-2-amine)