• 1. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 2. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 3. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 4. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 5. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives

Introduction to 5-Fluoro-3-formyl-2-methoxyphenylboronic Acid (CAS No. 1072951-73-5)

5-Fluoro-3-formyl-2-methoxyphenylboronic Acid, identified by the Chemical Abstracts Service Number (CAS No.) 1072951-73-5, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and materials science. This boronic acid derivative is characterized by its unique structural features, including a fluoro-substituent, a formyl group, and a methoxy group, which collectively contribute to its versatile reactivity and potential applications.

The compound belongs to the class of phenylboronic acids, which are widely recognized for their role as key intermediates in Suzuki-Miyaura cross-coupling reactions. These reactions are fundamental in the synthesis of complex organic molecules, particularly in the development of novel pharmaceuticals. The presence of the fluoro group in 5-Fluoro-3-formyl-2-methoxyphenylboronic Acid introduces additional electronic and steric properties, making it an attractive building block for medicinal chemists seeking to optimize drug-like properties such as metabolic stability, solubility, and binding affinity.

The formyl group in the molecule serves as a reactive site for further functionalization, enabling the construction of diverse molecular architectures. This reactivity is particularly valuable in the context of drug discovery, where the ability to append various pharmacophores is crucial for achieving desired biological activities. Moreover, the methoxy substituent can influence the electronic distribution of the aromatic ring, thereby modulating interactions with biological targets.

In recent years, there has been a surge in research focused on boronic acid derivatives due to their broad utility in both academic and industrial settings. The pharmaceutical industry has leveraged these compounds to develop innovative therapeutic agents targeting various diseases. For instance, boronic acids have been employed in the design of protease inhibitors, which are critical in treating conditions such as cancer and infectious diseases. The unique properties of 5-Fluoro-3-formyl-2-methoxyphenylboronic Acid make it a promising candidate for such applications.

One of the most compelling aspects of this compound is its potential role in the development of fluorinated drugs. Fluorine atoms are frequently incorporated into pharmaceuticals due to their ability to enhance metabolic stability, improve binding affinity, and prolong half-life. The strategic placement of a fluoro group at the 5-position of the phenyl ring in 5-Fluoro-3-formyl-2-methoxyphenylboronic Acid ensures that these benefits can be harnessed in drug design. This has been particularly relevant in recent studies exploring fluorinated analogs of existing drugs, where modifications at key positions have led to significant improvements in efficacy and safety.

The synthetic utility of 5-Fluoro-3-formyl-2-methoxyphenylboronic Acid extends beyond pharmaceutical applications. In materials science, boronic acids are employed in the development of smart materials and functional polymers. The ability to undergo cross-coupling reactions under mild conditions makes them ideal for constructing complex molecular frameworks with tailored properties. Researchers have utilized derivatives like this one to create polymers with enhanced thermal stability and mechanical strength, which are essential for advanced technological applications.

Recent advancements in computational chemistry have further highlighted the importance of 5-Fluoro-3-formyl-2-methoxyphenylboronic Acid as a key intermediate. High-throughput virtual screening methods have enabled scientists to rapidly evaluate thousands of compounds for their potential biological activity. The structural features of this boronic acid derivative make it a frequent hit in screens targeting enzyme inhibition and receptor binding. This has spurred interest in developing libraries based on similar scaffolds for future drug discovery efforts.

The role of boronic acids in nanotechnology is another emerging area where 5-Fluoro-3-formyl-2-methoxyphenylboronic Acid could play a significant role. Boron-containing compounds have been explored as components in nanocarriers for drug delivery systems due to their ability to form stable complexes with other molecules. The reactivity and structural versatility of this compound make it a candidate for designing innovative nanomaterials that can enhance therapeutic outcomes.

In conclusion, 5-Fluoro-3-formyl-2-methoxyphenylboronic Acid (CAS No. 1072951-73-5) represents a valuable asset in modern chemical synthesis and drug development. Its unique structural composition offers multiple opportunities for functionalization and application across various domains, including pharmaceuticals, materials science, and nanotechnology. As research continues to uncover new methodologies for utilizing boronic acid derivatives, compounds like this one are likely to remain at the forefront of innovation.

• 480424-49-5((3-formyl-2-methoxyphenyl)boronic acid)
• 1072951-92-8((3,5-Diformyl-2-propoxyphenyl)boronic acid)
• 480424-52-0(3-Formyl-2-isopropoxy-5-methylphenylboronic acid)
• 913836-10-9(3-Borono-2-methoxybenzoic acid)
• 121124-97-8((3-formyl-4-methoxyphenyl)boronic acid)
• 1072951-68-8((3,5-Diformyl-2-isopropoxyphenyl)boronic acid)
• 480424-63-3(3-Formyl-4-ethoxyphenylboronic acid)
• 480424-53-1(3-Formyl-5-methyl-2-propoxyphenylboronic acid)
• 480424-54-2(2-Ethoxy-3-formyl-5-methylphenylboronic acid)
• 480424-51-9(2-Butoxy-3-formyl-5-methylphenylboronic acid)