Cas no 1072-98-6 (2-Amino-5-chloropyridine)
2-Amino-5-chloropyridine Chemical and Physical Properties
Names and Identifiers
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- 2-Amino-5-chloropyridine
- 2-AMINO-5-CHLIROPYRIDINE
- 2-Amino-5-Chloro Pyriine
- 2-amino-5-chloro-pyridine
- 5-CHLORO-2-AMINOPYRIDINE
- 5-CHLORO-A-PYRIDYLAMINE
- 5-CHLOROPYRIDIN-2-AMINE
- 5-chloropyridin-2-ylamine
- 6-chloropyridin-2-ylamine
- AKOS 91155
- TIMTEC-BB SBB000059
- Edoxaban Impurity 14
- 5-CHLORO-2-PYRIDYLAMINE
- 5-CHLORO-2-PYRIDINAMINE
- 2-Amino-5-chlorophridine
- 5-Chloro-a-aminopyridine
- 5-Chloro-2-pyridineamine
- 2-Pyridinamine, 5-chloro-
- Pyridine, 2-amino-5-chloro-
- 2-amino-5-chloro pyridine
- 5-chloro-pyridin-2-ylamine
- amino(2-)-5-chloropyridine
- MAXBVGJEFDMHNV-UHFFFAOYSA-N
- NSC26283
- PubChem1153
- 2-amino5-chloropyridine
- 2-amino-5chloropyridine
- 2-amino-5-chloropyridin
- 2-amin
- 2-amino-5-cloropyridine
- 2-amino-5-chloro
- DTXSID0073247
- NS00021491
- 2-AMino-5-chloropyridine--d3
- AB00712
- (5-chloro-pyridin-2-yl)-amine
- 2-Amino-5-chloropyridine, 98%
- AG-617/02036012
- 1072-98-6
- STR00702
- AC-2429
- Q-103358
- PS-3640
- 2-Amino-5-chloropyridine, British Pharmacopoeia (BP) Reference Standard
- NSC-26283
- MFCD00006324
- AI3-52448
- NSC 26283
- SY001089
- A0837
- EN300-19819
- Z104475596
- AB2782
- 5-chloropyridine-2-amine
- EINECS 214-020-4
- RP-26695
- 5-Chloro-2-pyridinamine;5-Chloropyridin-2-amine
- AKOS025397221
- CS-W018533
- BCP23345
- AM20050652
- J8TAP6NFD4
- SCHEMBL77304
- 2-amino-5-chloropyrdine
- FT-0611162
- BP-12769
- 2-Amino-5-chloropyridine, purum, >=98.0% (NT)
- F0001-0149
- CCG-325545
- InChI=1/C5H5ClN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8
- AKOS000119653
- 5-chloropyridin-2(1H)-imine
- STK398098
- DB-014014
- AC-907/34116008
- STL453491
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- MDL： MFCD00006324
- Inchi： 1S/C5H5ClN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8)
- InChI Key： MAXBVGJEFDMHNV-UHFFFAOYSA-N
- SMILES： ClC1=CN=C(C=C1)N
- BRN： 108735
Computed Properties
- Exact Mass: 128.01400
- Monoisotopic Mass: 128.014126
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 8
- Rotatable Bond Count: 0
- Complexity: 76.8
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 1.1
- Topological Polar Surface Area: 38.9
- Molecular Weight: 128.56
- Surface Charge: 0
- Tautomer Count: 2
Experimental Properties
- Color/Form: Beige to brown flake crystals.
- Density: 1.2417 (rough estimate)
- Melting Point: 135-138?°C (lit.)
- Boiling Point: 127-128?°C/11?mmHg(lit.)
- Flash Point: Fahrenheit: 320 ° f
Celsius: 160 ° c - Refractive Index: 1.5110 (estimate)
- Solubility: 1.0g/l
- Water Partition Coefficient: 1 g/L (20 oC)
- PSA: 38.91000
- LogP: 1.89840
- Solubility: Soluble in water and ethanol.
- FEMA: 3202
- Vapor Pressure: 0.0±0.5 mmHg at 25°C
- Sensitiveness: Sensitive to light and air
2-Amino-5-chloropyridine Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Warning
- Hazard Statement： H302
- Warning Statement： P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 22
- Safety Instruction： S22-S24/25-S37/39-S26
-
Hazardous Material Identification：
- Risk Phrases：R22; R36/37/38
- HazardClass：IRRITANT
- Storage Condition：2-8°C
- Safety Term：S26;S37/39
2-Amino-5-chloropyridine Customs Data
- HS CODE：2942000000
- Customs Data：
China Customs Code:
2933399090Overview:
2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
2-Amino-5-chloropyridine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | A800531-2.5kg |
2-Amino-5-chloropyridine |
1072-98-6 | 98% | 2.5kg |
2,418.00 | 2021-05-17 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | BP813 |
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1072-98-6 | 25mg |
￥1978.36 | 2023-04-24 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | A46803-25G |
2-Amino-5-chloropyridine |
1072-98-6 | 25g |
￥230.17 | 2023-11-11 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | A46803-100G |
2-Amino-5-chloropyridine |
1072-98-6 | 100g |
￥703.11 | 2023-11-11 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | A46803-500G |
2-Amino-5-chloropyridine |
1072-98-6 | 98% | 500G |
￥3227.71 | 2022-02-24 | |
| Matrix Scientific | 021118-100g |
2-Amino-5-chloropyridine, 98% |
1072-98-6 | 98% | 100g |
$29.00 | 2023-09-09 | |
| Matrix Scientific | 021118-500g |
2-Amino-5-chloropyridine, 98% |
1072-98-6 | 98% | 500g |
$119.00 | 2023-09-09 | |
| Matrix Scientific | 021118-1kg |
2-Amino-5-chloropyridine, 98% |
1072-98-6 | 98% | 1kg |
$207.00 | 2023-09-09 | |
| ChemScence | CS-W018533-500g |
2-Amino-5-chloropyridine |
1072-98-6 | 99.87% | 500g |
$96.0 | 2022-04-28 | |
| ChemScence | CS-W018533-1000g |
2-Amino-5-chloropyridine |
1072-98-6 | 99.87% | 1000g |
$167.0 | 2021-09-02 |
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2-Amino-5-chloropyridine Related Literature
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1. Reactions of N-heteroaromatic bases with nitrous acid. Part 5. Kinetics of the diazotisation of substituted 2-aminopyridine and 2-aminopyridine 1-oxideEvangelos Kalatzis,Christos Mastrokalos J. Chem. Soc. Perkin Trans. 2 1977 1835
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2. The electric dipole moments of chloro-anilines and of some chloro-, bromo-, and nitro-substituted amino-pyridines in benzene and 1,4-dioxan solutionsC. W. N. Cumper,A. Singleton J. Chem. Soc. B 1968 645
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Atiyyah Salajee,Caitlin Morrison,Rudolph Erasmus,Andreas Lemmerer CrystEngComm 2022 24 6297
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B. Babu,J. Chandrasekaran,B. Mohanbabu,Yoshitaka Matsushita,M. Saravanakumar RSC Adv. 2016 6 110884
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5. The kinetics and mechanism of the electrophilic substitution of heteroaromatic compounds. Part XXV. The acid-catalysed hydrogen-exchange of some 2-aminopyridine derivativesA. El-Anani,P. E. Jones,A. R. Katritzky J. Chem. Soc. B 1971 2363
Additional information on 2-Amino-5-chloropyridine
Introduction to 2-Amino-5-chloropyridine (CAS No. 1072-98-6)
2-Amino-5-chloropyridine, with the chemical formula C?H?ClN?, is a significant intermediate in pharmaceutical and agrochemical synthesis. Its unique structure, featuring both an amino group and a chloropyridine ring, makes it a versatile building block for various biologically active compounds. This compound has garnered considerable attention in recent years due to its role in the development of novel therapeutic agents.
The CAS No. 1072-98-6 uniquely identifies this chemical entity in scientific literature and industrial applications. Its molecular structure allows for diverse functionalization, making it a valuable precursor in medicinal chemistry. The presence of both electron-donating and electron-withdrawing groups facilitates its participation in various organic reactions, including nucleophilic substitution and condensation reactions.
In the realm of pharmaceutical research, 2-amino-5-chloropyridine has been extensively studied for its potential in synthesizing small-molecule inhibitors targeting various disease pathways. Recent studies have highlighted its utility in developing kinase inhibitors, which are crucial in treating cancers and inflammatory diseases. The chloropyridine moiety enhances binding affinity to biological targets, while the amino group provides a site for further chemical modifications.
One of the most compelling applications of 2-amino-5-chloropyridine is in the synthesis of antiviral agents. Researchers have demonstrated its role in creating compounds that inhibit viral protease enzymes, which are essential for viral replication. The structural features of this compound allow it to mimic natural substrates, thereby disrupting viral mechanisms effectively. This has opened new avenues for developing treatments against emerging viral threats.
The agrochemical industry has also leveraged 2-amino-5-chloropyridine to develop novel pesticides and herbicides. Its derivatives exhibit potent activity against a range of pests while maintaining environmental safety profiles. The ability to modify its structure enables chemists to fine-tune its biological activity, ensuring efficacy with minimal ecological impact.
Advances in synthetic methodologies have further enhanced the accessibility and utility of 2-amino-5-chloropyridine. Modern catalytic processes allow for more efficient and scalable production, reducing costs and improving yields. These innovations have made it easier for researchers to explore its potential in drug discovery and material science.
The chemical properties of 2-amino-5-chloropyridine make it an excellent candidate for exploring new synthetic pathways. Its reactivity with various nucleophiles and electrophiles allows for the creation of complex molecules with tailored properties. This flexibility is particularly valuable in designing molecules with specific biological activities.
In conclusion, 2-amino-5-chloropyridine (CAS No. 1072-98-6) is a multifaceted compound with broad applications in pharmaceuticals, agrochemicals, and material science. Its unique structural features enable diverse functionalization, making it an indispensable tool in modern chemistry. As research continues to uncover new uses for this compound, its importance is likely to grow even further.
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