• 1. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 2. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 3. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 4. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 5. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Methylpyridines

Comprehensive Guide to 2-Methyl-4-(trifluoromethyl)pyridine (CAS No. 106877-17-2): Properties, Applications, and Market Insights

2-Methyl-4-(trifluoromethyl)pyridine (CAS No. 106877-17-2) is a versatile heterocyclic compound that has gained significant attention in pharmaceutical and agrochemical research. This fluorinated pyridine derivative serves as a crucial building block in modern organic synthesis, particularly for developing advanced materials and bioactive molecules. With its unique trifluoromethyl group and methyl substitution, this compound offers exceptional chemical properties that make it valuable across multiple industries.

The growing demand for 2-methyl-4-trifluoromethyl pyridine stems from its remarkable stability and reactivity profile. Researchers particularly value its electron-withdrawing properties and lipophilicity enhancement capabilities, which are essential for drug design and material science applications. Recent studies highlight its importance in developing crop protection agents and pharmaceutical intermediates, aligning with current trends in sustainable agriculture and precision medicine.

From a chemical perspective, 2-Methyl-4-(trifluoromethyl)pyridine exhibits several noteworthy characteristics. The compound's molecular structure features a pyridine ring substituted at the 2-position with a methyl group and at the 4-position with a trifluoromethyl group. This arrangement creates unique electronic effects that influence its reactivity patterns. The trifluoromethyl pyridine moiety contributes to increased metabolic stability and improved bioavailability when incorporated into larger molecular frameworks, making it particularly valuable in medicinal chemistry applications.

In pharmaceutical applications, 2-methyl-4-CF3-pyridine serves as a key intermediate for various drug discovery programs. Its structural features are frequently employed to modify drug-like properties of candidate compounds, including solubility, membrane permeability, and target binding affinity. The compound's versatility allows for diverse chemical transformations, enabling the synthesis of numerous derivatives with potential biological activity. Recent patent literature reveals its use in developing therapies for neurological disorders and metabolic diseases.

The agrochemical industry has also embraced 2-methyl-4-(trifluoromethyl)pyridine as a valuable scaffold for crop protection products. Its incorporation into pesticide formulations enhances product performance through improved pest resistance management and environmental stability. The compound's structural features contribute to the development of next-generation plant protection agents with reduced environmental impact and higher target specificity, addressing current concerns about sustainable agriculture practices.

Material science applications of 2-methyl-4-trifluoromethyl pyridine are expanding rapidly. Researchers are exploring its potential in creating advanced functional materials, including liquid crystals, organic semiconductors, and specialty polymers. The compound's ability to influence material properties through its unique electronic characteristics makes it particularly interesting for developing new technologies in electronics and optoelectronics.

Market analysis indicates steady growth in demand for 2-Methyl-4-(trifluoromethyl)pyridine across various regions. The compound's supply chain dynamics reflect the increasing importance of fluorinated building blocks in chemical manufacturing. Industry reports suggest that manufacturers are investing in improved synthesis methods to enhance yield and purity while reducing production costs. This aligns with the broader trend toward more efficient and sustainable chemical processes in the specialty chemicals sector.

Quality control standards for 2-methyl-4-CF3-pyridine have become increasingly stringent, with most suppliers offering high-purity grades (≥98%) suitable for research and industrial applications. Analytical techniques such as GC-MS and HPLC are routinely employed to verify the compound's identity and purity. Proper storage conditions (typically under inert atmosphere at low temperatures) are recommended to maintain stability and prevent degradation over time.

Recent advancements in synthetic chemistry have led to improved methods for producing 2-methyl-4-(trifluoromethyl)pyridine. Modern approaches focus on catalytic processes and atom-economical reactions that minimize waste generation and energy consumption. These developments address growing concerns about green chemistry principles and sustainable manufacturing practices in the chemical industry.

The future outlook for 2-Methyl-4-(trifluoromethyl)pyridine appears promising, with potential applications emerging in areas such as bioconjugation chemistry and materials engineering. As research continues to uncover new uses for this versatile compound, its importance in various scientific and industrial fields is expected to grow significantly in the coming years.

• 1416354-37-4(2-Methyl-4-(trifluoromethyl)pyridine hydrochloride)
• 324-32-3(2-Methyl-7-(trifluoromethyl)quinoline)
• 512197-90-9(2-ethynyl-4-(trifluoromethyl)pyridine)
• 1620-79-7(4-Methyl-2-(trifluoromethyl)pyridine)
• 76068-40-1(Quinoline, 2-methyl-4-(trifluoromethyl)-)
• 749256-94-8(Pyridine, 2,4-dimethyl-6-(trifluoromethyl)- (Related Reference))
• 515845-73-5(BENZO[H]QUINOLINE, 2-METHYL-4-(TRIFLUOROMETHYL)-)
• 161406-41-3(PYRIDINE, 2,4,6-TRIS(TRIFLUOROMETHYL)-)
• 454-99-9(2,4-Bis(trifluoromethyl)pyridine)
• 911387-38-7(4-(fluoromethyl)-2,6-dimethyl-Pyridine)