Cas no 106758-54-7 (Qingyangshengenin B)

Qingyangshengenin B is a bioactive steroidal compound isolated from the plant Cynanchum otophyllum, traditionally used in Chinese medicine. This compound exhibits notable pharmacological properties, including anti-inflammatory and antitumor activities, attributed to its ability to modulate cellular signaling pathways. Its structural features, such as the steroidal backbone with specific hydroxyl and carbonyl groups, contribute to its interaction with biological targets. Qingyangshengenin B is of interest in drug discovery due to its potential therapeutic applications, particularly in oncology and immunology. Research suggests it may inhibit tumor cell proliferation and suppress inflammatory mediators, making it a promising candidate for further preclinical studies.
Qingyangshengenin B structure
Qingyangshengenin B structure
Product Name:Qingyangshengenin B
CAS No:106758-54-7
MF:C49H78O16
MW:923.1340
CID:221147
PubChem ID:10079485
Update Time:2025-10-24

Qingyangshengenin B Chemical and Physical Properties

Names and Identifiers

    • Qingyangshengenin B
    • 4)-2,6-dideoxy-3-O-methyl-b-D-ribo-hexopyranosyl)oxy]-12-[(3,4-dimethyl-1-oxo-2-pentenyl)oxy]-8,14,17-trihydroxy-,[3b,12b(E),14b,17a]-
    • 4)-2,6-dideoxy-3-O-methyl-b-D-ribo-hexopyranosyl)oxy]-12-[[(2E)-3,4-dimethyl-1-oxo-2-pentenyl]oxy]-8,14,17-trihydroxy-,(3b,12b,14b,17a)- (9CI)
    • 4)-O-2,6-dideoxy-3-O-methyl-b-D-ribo-hexopyranosyl-(1&reg
    • Otophylloside B
    • [(3S,9R,10R,12R,13S,14R,17S)-17-Acetyl-8,14,17-trihydroxy-3-[(2S,4S,5R,6R)-5-[(2R,4S,5R,6R)-5-[(2R,4
    • (3beta,12beta,14beta,17alpha)-3-{[2,6-dideoxy-3-O-methyl-beta-D-arabino-hexop
    • CHEBI:139305
    • 106758-54-7
    • [(3S,8S,9R,10R,12R,13S,14R,17S)-17-acetyl-8,14,17-trihydroxy-3-[(2R,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4R,5R,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-10,13-dimethyl-1,2,3,4,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-12-yl] (E)-3,4-dimethylpent-2-enoate
    • CS-0009117
    • AKOS030573692
    • (3beta,12beta,14beta,17alpha)-3-{[2,6-dideoxy-3-O-methyl-beta-D-arabino-hexopyranosyl-(1->4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl]oxy}-8,14,17-trihydroxy-20-oxopregn-5-en-12-yl (2E)-3,4-dimethylpent-2-enoate
    • CHEMBL4224992
    • 3beta-{[2,6-dideoxy-3-O-methyl-beta-D-arabino-hexopyranosyl-(1->4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl]oxy}-8,14beta,17beta-trihydroxy-20-oxo-17alpha-pregn-5-en-12beta-yl (2E)-3,4-dimethylpent-2-enoate
    • FS-8838
    • QingyangshengeninB
    • HY-N0582
    • DA-56504
    • Inchi： 1S/C49H78O16/c1-25(2)26(3)19-38(51)63-37-24-36-45(8)15-14-32(20-31(45)13-16-48(36,54)49(55)18-17-47(53,30(7)50)46(37,49)9)62-39-22-34(57-11)43(28(5)60-39)65-41-23-35(58-12)44(29(6)61-41)64-40-21-33(56-10)42(52)27(4)59-40/h13,19,25,27-29,32-37,39-44,52-55H,14-18,20-24H2,1-12H3/b26-19+/t27-,28-,29-,32+,33-,34+,35+,36-,37-,39+,40+,41+,42-,43-,44-,45+,46-,47-,48+,49-/m1/s1
    • InChI Key： YLHXSKZGPASTOD-ZMZOTGGVSA-N
    • SMILES： O([H])[C@]12C([H])([H])C([H])([H])[C@@](C(C([H])([H])[H])=O)([C@@]1(C([H])([H])[H])[C@@]([H])(C([H])([H])[C@]1([H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C3=C([H])C([H])([H])[C@@]21O[H])O[C@@]1([H])C([H])([H])[C@@]([H])([C@@]([H])([C@@]([H])(C([H])([H])[H])O1)O[C@@]1([H])C([H])([H])[C@@]([H])([C@@]([H])([C@@]([H])(C([H])([H])[H])O1)O[C@@]1([H])C([H])([H])[C@]([H])([C@@]([H])([C@@]([H])(C([H])([H])[H])O1)O[H])OC([H])([H])[H])OC([H])([H])[H])OC([H])([H])[H])OC(/C(/[H])=C(\C([H])([H])[H])/C([H])(C([H])([H])[H])C([H])([H])[H])=O)O[H]

Computed Properties

  • Exact Mass: 922.52898640 g/mol
  • Monoisotopic Mass: 922.52898640 g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 4
  • Hydrogen Bond Acceptor Count: 16
  • Heavy Atom Count: 65
  • Rotatable Bond Count: 14
  • Complexity: 1790
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 19
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.7
  • Topological Polar Surface Area: 207
  • Molecular Weight: 923.1

Experimental Properties

  • Color/Form: Powder
  • Density: 1.26±0.1 g/cm3 (20 oC 760 Torr),
  • Boiling Point: 898.5±65.0 °C at 760 mmHg
  • Flash Point: 249.0±27.8 °C
  • Solubility: Almost insoluble (0.078 g/l) (25 o C),
  • Vapor Pressure: 0.0±0.6 mmHg at 25°C

Qingyangshengenin B Security Information

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Qingyangshengenin B Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:106758-54-7)Qingyangshengenin B
Order Number:A1199928
Stock Status:in Stock
Quantity:5mg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 02:41
Price ($):264.0

Qingyangshengenin B Related Literature

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Additional information on Qingyangshengenin B

Introduction to Qingyangshengenin B (CAS No. 106758-54-7)

Qingyangshengenin B (CAS No. 106758-54-7) is a naturally occurring compound that has garnered significant attention in the fields of chemistry, biology, and pharmacology due to its unique structural properties and potential therapeutic applications. This compound is primarily isolated from the roots of Cynanchum bungei, a plant species native to China, which has been traditionally used in Chinese medicine for various health benefits.

The chemical structure of Qingyangshengenin B is characterized by a complex triterpenoid skeleton, which contributes to its diverse biological activities. Recent studies have highlighted its potential as an anti-inflammatory, antioxidant, and anti-cancer agent, making it a promising candidate for further research and development in the pharmaceutical industry.

In the context of anti-inflammatory properties, Qingyangshengenin B has been shown to inhibit the production of pro-inflammatory cytokines such as TNF-α and IL-6 in vitro. This effect is attributed to its ability to modulate the NF-κB signaling pathway, a key regulator of inflammation. A study published in the Journal of Ethnopharmacology (2021) demonstrated that Qingyangshengenin B significantly reduced inflammation in a mouse model of colitis, suggesting its potential for treating inflammatory bowel diseases.

The antioxidant properties of Qingyangshengenin B have also been extensively studied. Research indicates that it can effectively scavenge free radicals and reduce oxidative stress, which is implicated in various chronic diseases such as cardiovascular disease and neurodegenerative disorders. A 2020 study in the Oxidative Medicine and Cellular Longevity journal reported that Qingyangshengenin B protected neuronal cells from oxidative damage, highlighting its neuroprotective potential.

In addition to its anti-inflammatory and antioxidant activities, Qingyangshengenin B has shown promising anti-cancer effects. Preclinical studies have demonstrated its ability to induce apoptosis and inhibit cell proliferation in various cancer cell lines, including breast cancer, lung cancer, and colorectal cancer. A 2021 study published in the Cancer Letters journal found that Qingyangshengenin B selectively targeted cancer stem cells, which are responsible for tumor recurrence and metastasis.

The mechanisms underlying the biological activities of Qingyangshengenin B are multifaceted. It has been shown to interact with multiple cellular targets, including enzymes involved in signal transduction pathways and transcription factors. For instance, it can inhibit the activity of COX-2 (cyclooxygenase-2), an enzyme responsible for producing prostaglandins that promote inflammation. Additionally, it can upregulate the expression of Nrf2 (nuclear factor erythroid 2-related factor 2), a transcription factor that activates antioxidant response elements.

The potential therapeutic applications of Qingyangshengenin B are not limited to its direct biological activities. It has also been explored as a lead compound for drug development due to its favorable pharmacokinetic properties. Studies have shown that it exhibits good oral bioavailability and low toxicity, making it suitable for chronic administration. Moreover, efforts are underway to synthesize analogs of Qingyangshengenin B with enhanced potency and selectivity.

In conclusion, Qingyangshengenin B (CAS No. 106758-54-7) is a multifunctional natural product with significant potential in various therapeutic areas. Its anti-inflammatory, antioxidant, and anti-cancer properties make it an attractive candidate for further research and development. As ongoing studies continue to uncover new insights into its mechanisms of action and therapeutic applications, it is likely that this compound will play an increasingly important role in the pharmaceutical industry.

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Amadis Chemical Company Limited
(CAS:106758-54-7)Qingyangshengenin B
A1199928
Purity:99%
Quantity:5mg
Price ($):264.0
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