• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Haloquinolines

Professional Introduction to 7-Bromo-4-methoxyquinoline (CAS No. 1065092-89-8)

7-Bromo-4-methoxyquinoline, identified by the Chemical Abstracts Service Number (CAS No.) 1065092-89-8, is a heterocyclic organic compound that has garnered significant attention in the field of pharmaceutical chemistry and medicinal research. This compound belongs to the quinoline family, a class of molecules known for their broad spectrum of biological activities and utility in drug development. The structural features of 7-Bromo-4-methoxyquinoline, including the presence of both bromine and methoxy substituents, make it a versatile scaffold for further chemical modifications and functionalization, enabling its exploration in various therapeutic applications.

The quinoline scaffold has a rich history in medicinal chemistry, with several well-known drugs derived from this core structure. Notably, derivatives of quinoline have been instrumental in the treatment of malaria, tuberculosis, and other infectious diseases. The introduction of halogen atoms, such as bromine, into the quinoline ring enhances its reactivity and allows for further derivatization, making it an attractive intermediate in synthetic chemistry. The methoxy group at the 4-position adds another layer of functional diversity, influencing both the electronic properties and solubility characteristics of the molecule.

In recent years, 7-Bromo-4-methoxyquinoline has been extensively studied for its potential in drug discovery. Its unique structural motif has been explored in the development of compounds targeting various disease pathways. One particularly promising area of research involves its application in anticancer therapies. Quinoline derivatives have demonstrated efficacy in inhibiting kinases and other enzymes involved in tumor growth and progression. The bromine atom at the 7-position serves as a handle for palladium-catalyzed cross-coupling reactions, enabling the introduction of additional functional groups such as aryl or heteroaryl moieties. These modifications have led to the synthesis of novel analogs with enhanced biological activity.

Furthermore, 7-Bromo-4-methoxyquinoline has shown promise in the field of antimicrobial research. The quinoline core exhibits broad-spectrum antimicrobial properties, making it a valuable starting point for developing new antibiotics. The presence of both bromine and methoxy groups allows for selective modifications that can fine-tune the antimicrobial activity against specific pathogens. Recent studies have highlighted its potential as an antifungal agent, with derivatives demonstrating efficacy against resistant strains of Candida albicans.

The compound's utility extends beyond anticancer and antimicrobial applications. Researchers have also investigated its role in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Quinoline derivatives have been shown to modulate neurotransmitter systems and inhibit enzymes associated with neurodegeneration. The structural flexibility of 7-Bromo-4-methoxyquinoline allows for the design of molecules that can interact with specific targets in the central nervous system, offering hope for new therapeutic strategies.

In addition to its pharmacological applications, 7-Bromo-4-methoxyquinoline has found use in material science and chemical biology. Its ability to undergo various functionalization reactions makes it a valuable building block for synthesizing complex organic molecules. These derivatives have been employed in studying enzyme mechanisms and developing probes for biological assays. The compound's compatibility with modern synthetic methodologies ensures its continued relevance in academic and industrial research settings.

The synthesis of 7-Bromo-4-methoxyquinoline typically involves multi-step organic transformations starting from readily available precursors. Common synthetic routes include bromination followed by methylation or vice versa, depending on the desired regioselectivity. Advances in catalytic systems have improved the efficiency and scalability of these reactions, making it feasible to produce larger quantities for research purposes. The compound's stability under various storage conditions further enhances its practicality as a laboratory reagent.

From a computational chemistry perspective, 7-Bromo-4-methoxyquinoline has been subjected to detailed molecular modeling studies to understand its interactions with biological targets. Quantum mechanical calculations have provided insights into its electronic structure and reactivity patterns, aiding in the rational design of more potent derivatives. These computational approaches are increasingly integrated into drug discovery pipelines, complementing experimental efforts and accelerating the development process.

The future prospects for 7-Bromo-4-methoxyquinoline are vast, with ongoing research exploring new therapeutic applications and synthetic methodologies. As our understanding of disease mechanisms evolves, so too does our ability to harness this versatile scaffold for innovative drug development. Collaborative efforts between academia and industry are essential to translate these findings into tangible benefits for patients worldwide.

• 82121-06-0(7-Bromoquinolin-4-ol)
• 959121-99-4(3-bromo-7-methoxy-quinoline)
• 1070879-27-4(4-bromo-7-methoxy-quinoline)
• 393553-57-6(6-Bromo-4-methoxy-1H-indole)
• 1126824-44-9(5-Bromo-7-methoxyquinoline)
• 874792-20-8(6-Bromo-4-methoxyquinoline)
• 874831-36-4(8-Bromo-4-methoxyquinoline)
• 42881-66-3(4-Bromo-6-methoxyquinoline)
• 666734-51-6(4-Bromo-6,7-dimethoxyquinoline)
• 393553-55-4(4-Bromo-6-methoxy-1H-indole)