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Comprehensive Overview of (2-methyl-1,3-oxazol-4-yl)methanamine (CAS No. 1065073-45-1): Properties, Applications, and Industry Insights

The compound (2-methyl-1,3-oxazol-4-yl)methanamine, identified by its CAS No. 1065073-45-1, is a specialized organic molecule featuring a 1,3-oxazole core with a methyl substituent at the 2-position and an aminomethyl group at the 4-position. This structure endows it with unique reactivity, making it a valuable intermediate in pharmaceutical and agrochemical research. The oxazole ring is a privileged scaffold in drug discovery due to its hydrogen-bonding capacity and metabolic stability, aligning with modern trends in small-molecule therapeutics and fragment-based drug design.

Recent advancements in heterocyclic chemistry have spotlighted derivatives like (2-methyl-1,3-oxazol-4-yl)methanamine as key building blocks for kinase inhibitors and GPCR-targeted compounds. Its CAS No. 1065073-45-1 is frequently queried in scientific databases, reflecting growing interest in structure-activity relationship (SAR) studies. Researchers leverage its bifunctional nature (amine + heterocycle) to develop covalent inhibitors or PROTACs—topics trending in AI-driven drug discovery forums.

From a synthetic perspective, 1065073-45-1 is often synthesized via cyclocondensation of α-haloketones with amides or through multicomponent reactions (MCRs), methods popularized by green chemistry initiatives. Its logP and pKa values (predicted via computational chemistry tools) make it suitable for blood-brain barrier penetration studies—a hot topic in neurodegenerative disease research.

In material science, the oxazole amine moiety contributes to photoactive polymers and OLED emitters, addressing demands for energy-efficient displays. Patent analyses reveal its utility in electronic-grade coatings, coinciding with surges in searches for flexible electronics materials.

Regulatory-wise, CAS 1065073-45-1 is compliant with major chemical inventories (e.g., REACH, TSCA), though users should verify local guidelines. Safety data sheets emphasize standard organic lab precautions, avoiding misclassification as hazardous—a critical distinction for ESG-conscious manufacturers.

The compound’s versatility is further evidenced by its role in bioconjugation techniques, particularly in antibody-drug conjugates (ADCs)—a field experiencing 20% annual growth. Its primary amine enables NHS ester coupling, a staple in proteomics workflows frequently discussed in biotech webinars.

Market analysts note rising procurement of 1065073-45-1 by CDMOs serving mRNA vaccine supply chains, where oxazoles stabilize lipid nanoparticles (LNPs). This application dovetails with post-pandemic focus on nucleic acid delivery systems—a top Google Scholar keyword since 2021.

For quality control, HPLC-UV at 254 nm is standard, though LC-MS gains traction for trace analysis. Purity thresholds (>98%) align with ICH Q3A guidelines, a frequent search term among QC professionals optimizing analytical method validation.

• 100959-91-9(2-Methyloxazole-4-carboxamide)
• 162739-94-8(1-(2-Isopropyloxazol-4-yl)-N-methylmethanamine)
• 55242-82-5(1,3-oxazol-4-ylmethanamine)
• 15924-16-0((2-Isopropyloxazol-4-yl)methanamine hydrochloride)
• 1053059-18-9(2-(propan-2-yl)-1,3-oxazol-4-ylmethanamine)
• 1541489-02-4(2-methyl-1,3-oxazole-4-carboximidamide)
• 1065073-46-2(N-Methyl-(2-methyl-1,3-oxazol-4-yl)methylamine)
• 7208-05-1(2,4-Dimethyloxazole)
• 1052546-96-9(4-(Aminomethyl)-2-isopropyloxazole hydrochloride)
• 1072806-60-0(4-Oxazolemethanamine hydrochloride)