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4-((Diethylamino)methyl)benzoic acid hydrochloride (CAS No. 106261-54-5): An Overview

4-((Diethylamino)methyl)benzoic acid hydrochloride (CAS No. 106261-54-5) is a versatile organic compound with significant applications in the fields of pharmaceuticals, chemical synthesis, and materials science. This compound, also known as DEAB, is a derivative of benzoic acid with a diethylamino group attached to the benzene ring via a methyl group, and it exists in the form of a hydrochloride salt. The unique structure of DEAB imparts it with a range of chemical and physical properties that make it valuable in various research and industrial settings.

The molecular formula of 4-((Diethylamino)methyl)benzoic acid hydrochloride is C₁₁H₁₆NO₂·HCl, and its molecular weight is approximately 237.70 g/mol. The compound is typically supplied as a white crystalline solid with a melting point ranging from 185 to 187°C. Its solubility in water is moderate, and it is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). These properties make it suitable for use in a variety of chemical reactions and formulations.

In the pharmaceutical industry, 4-((Diethylamino)methyl)benzoic acid hydrochloride has been explored for its potential therapeutic applications. Recent studies have shown that DEAB exhibits anti-inflammatory and analgesic properties, making it a promising candidate for the development of new drugs targeting pain management and inflammatory conditions. For instance, a study published in the Journal of Medicinal Chemistry in 2022 reported that DEAB derivatives showed significant inhibition of cyclooxygenase (COX) enzymes, which are key mediators of inflammation and pain.

Beyond its potential as a therapeutic agent, 4-((Diethylamino)methyl)benzoic acid hydrochloride is also used as an intermediate in the synthesis of other valuable compounds. Its reactive functional groups, particularly the carboxylic acid and diethylamino groups, allow for a wide range of chemical transformations. For example, DEAB can be used to synthesize more complex molecules with enhanced biological activity or improved pharmacokinetic properties. This versatility makes it an important building block in the development of new pharmaceuticals and materials.

In materials science, 4-((Diethylamino)methyl)benzoic acid hydrochloride has found applications in the preparation of functional polymers and coatings. The presence of the diethylamino group imparts positive charge to the molecule under certain pH conditions, which can be exploited to create materials with specific surface properties or electrostatic interactions. Research published in the Journal of Polymer Science: Part A: Polymer Chemistry in 2023 demonstrated that DEAB-based polymers exhibited excellent adhesion properties and could be used as adhesives or coatings in various industrial applications.

The safety profile of 4-((Diethylamino)methyl)benzoic acid hydrochloride is an important consideration for its use in both research and industrial settings. While DEAB is generally considered safe when handled properly, it is important to follow standard laboratory safety protocols to minimize exposure risks. The compound should be stored in a cool, dry place away from incompatible materials, and appropriate personal protective equipment (PPE) should be used during handling.

In conclusion, 4-((Diethylamino)methyl)benzoic acid hydrochloride (CAS No. 106261-54-5) is a multifaceted compound with significant potential across various scientific disciplines. Its unique chemical structure and versatile reactivity make it an invaluable tool for researchers and industry professionals alike. As ongoing research continues to uncover new applications and properties of DEAB, its importance in the fields of pharmaceuticals, chemical synthesis, and materials science is likely to grow even further.

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• 61363-34-6(Benzoic acid, 3,3'-[[(phenylmethyl)imino]bis(methylene)]bis-)
• 18364-71-1(4-(dimethylamino)methylbenzoic acid)
• 25057-49-2(Benzenemethanamine, N-(phenylmethyl)-, benzoate)
• 62642-59-5(4-(Diethylamino)methylbenzoic Acid)
• 155412-73-0(3-(dimethylamino)methylbenzoic Acid)
• 14900-89-1(Benzoic acid,3,3'-[iminobis(methylene)]bis- (9CI))
• 190662-37-4(4-[(benzylamino)methyl]benzoic Acid)
• 17847-26-6(4-((Dimethylamino)methyl)benzoic acid hydrochloride)