• 1. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
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• 2. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
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• 3. Dissociative dynamics of O2 on Ag(110)?
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• 4. Evolution of dealloying induced strain in nanoporous gold crystals?
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• 5. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
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2-Bromo-6-methyl-nicotinic Acid (CAS No. 1060810-09-4): An Overview of Its Properties, Applications, and Recent Research

2-Bromo-6-methyl-nicotinic Acid (CAS No. 1060810-09-4) is a versatile compound that has garnered significant attention in the fields of organic chemistry, medicinal chemistry, and pharmaceutical research. This compound is characterized by its unique structural features, which include a bromine atom and a methyl group attached to a nicotinic acid framework. These properties make it an attractive candidate for various applications, particularly in the development of novel pharmaceuticals and chemical intermediates.

The chemical structure of 2-Bromo-6-methyl-nicotinic Acid consists of a pyridine ring with a carboxylic acid group at the 3-position, a bromine atom at the 2-position, and a methyl group at the 6-position. This specific arrangement of functional groups imparts distinct chemical and physical properties to the molecule. The presence of the bromine atom makes it an excellent electrophilic substitution reagent, while the carboxylic acid group provides opportunities for further functionalization through esterification, amidation, and other reactions.

In terms of physical properties, 2-Bromo-6-methyl-nicotinic Acid is a white crystalline solid with a melting point of approximately 175°C. It is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), but has limited solubility in water. These solubility characteristics make it suitable for use in various synthetic protocols and analytical methods.

The synthesis of 2-Bromo-6-methyl-nicotinic Acid can be achieved through several routes. One common method involves the bromination of 6-methyl-nicotinic acid using N-bromosuccinimide (NBS) in an appropriate solvent such as acetic acid or dichloromethane. This reaction proceeds via an electrophilic aromatic substitution mechanism, leading to the formation of the desired product with high yields and purity. Another approach involves the direct bromination of nicotinic acid followed by methylation at the 6-position using methyl iodide or dimethyl sulfate.

Pharmaceutical applications of 2-Bromo-6-methyl-nicotinic Acid are diverse and promising. The compound has been investigated for its potential as a precursor in the synthesis of nicotinic acid receptor agonists, which have shown therapeutic potential in treating various neurological disorders such as Alzheimer's disease and Parkinson's disease. Additionally, derivatives of this compound have been explored for their anti-inflammatory and analgesic properties, making them valuable candidates for drug development.

Recent research studies have highlighted the importance of 2-Bromo-6-methyl-nicotinic Acid in medicinal chemistry. For instance, a study published in the *Journal of Medicinal Chemistry* reported the synthesis and biological evaluation of a series of 2-bromo-nicotinamide derivatives as potent inhibitors of protein-protein interactions involved in cancer progression. Another study in *Organic & Biomolecular Chemistry* described the use of 2-Bromo-6-methyl-nicotinic Acid as a key intermediate in the synthesis of novel nicotinamide adenine dinucleotide (NAD+) precursors, which have been shown to enhance cellular energy metabolism and promote longevity.

The safety profile of 2-Bromo-6-methyl-nicotinic Acid is an important consideration for its use in research and industrial applications. While it is generally considered safe when handled properly, appropriate personal protective equipment (PPE) should be used to avoid skin contact and inhalation. Additionally, it is important to store the compound in a cool, dry place away from incompatible materials to ensure its stability and prevent degradation.

In conclusion, 2-Bromo-6-methyl-nicotinic Acid (CAS No. 1060810-09-4) is a valuable compound with a wide range of applications in organic synthesis, medicinal chemistry, and pharmaceutical research. Its unique chemical structure and versatile reactivity make it an essential building block for the development of novel drugs and chemical intermediates. Ongoing research continues to uncover new possibilities for its use, further solidifying its importance in the scientific community.

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