• 1. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 2. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 3. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 4. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 5. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849

Research Brief on 5-Iodo-1H-1,3-benzodiazol-2-amine (CAS: 1060803-19-1): Recent Advances and Applications

5-Iodo-1H-1,3-benzodiazol-2-amine (CAS: 1060803-19-1) is a benzimidazole derivative that has garnered significant attention in recent chemical biology and pharmaceutical research due to its versatile applications in medicinal chemistry and drug discovery. This heterocyclic compound serves as a key intermediate in the synthesis of biologically active molecules, particularly in the development of kinase inhibitors and antiviral agents. Recent studies have explored its potential as a scaffold for designing novel therapeutic agents targeting various diseases.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the compound's utility as a building block for developing selective JAK2 inhibitors. The research team utilized 5-Iodo-1H-1,3-benzodiazol-2-amine as a core structure to create a series of derivatives showing promising activity against myeloproliferative disorders. The iodine substituent at the 5-position proved particularly valuable for further functionalization through palladium-catalyzed cross-coupling reactions, enabling rapid structure-activity relationship studies.

In the field of antiviral research, a recent publication in Bioorganic & Medicinal Chemistry Letters (2024) reported the incorporation of 5-Iodo-1H-1,3-benzodiazol-2-amine into novel compounds targeting the SARS-CoV-2 main protease. The electron-withdrawing iodine atom was found to enhance the binding affinity of these inhibitors by forming favorable interactions with key residues in the protease active site. Molecular docking studies supported by X-ray crystallography data revealed important structural insights that could guide future drug design efforts against coronaviruses.

The compound has also shown potential in materials science applications. A 2024 study in ACS Applied Materials & Interfaces explored its use as a precursor for organic electronic materials. When incorporated into conjugated polymers, derivatives of 5-Iodo-1H-1,3-benzodiazol-2-amine exhibited interesting photophysical properties, suggesting possible applications in organic light-emitting diodes (OLEDs) and biosensors. The researchers noted that the iodine atom facilitated efficient charge transport while maintaining good solubility in organic solvents.

From a synthetic chemistry perspective, recent advances have improved the preparation and purification of 5-Iodo-1H-1,3-benzodiazol-2-amine. A 2023 protocol in Organic Process Research & Development described an optimized synthetic route using continuous flow chemistry, which increased yield to 78% while reducing hazardous waste generation. This development is particularly significant for scaling up production while maintaining environmental sustainability.

Ongoing research continues to explore new applications for this versatile compound. Current clinical trials (Phase I/II) are investigating derivatives of 5-Iodo-1H-1,3-benzodiazol-2-amine as potential treatments for certain hematological malignancies, with preliminary results expected in late 2024. Additionally, several patent applications filed in 2024 describe novel uses of this scaffold in targeted protein degradation (PROTACs) and as fluorescent probes for cellular imaging.

As research progresses, 5-Iodo-1H-1,3-benzodiazol-2-amine continues to demonstrate its value as a multifunctional building block in drug discovery and materials science. Its unique combination of synthetic accessibility, derivatization potential, and biological activity makes it a compound of sustained interest in chemical biology research. Future directions may include exploring its use in covalent inhibitor design and as a component of supramolecular assemblies for drug delivery systems.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)