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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines
• Solvents and Organic Chemicals Organic Compounds Organic Halides
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone
• Pharmaceutical and Biochemical Products Pharmaceutical Intermediates
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients

Comprehensive Overview of 1-Methylpiperidin-4-ol (CAS No. 106-52-5): Properties, Applications, and Industry Insights

1-Methylpiperidin-4-ol (CAS No. 106-52-5), a versatile organic compound, has garnered significant attention in pharmaceutical and chemical research due to its unique structural properties. This secondary alcohol, featuring a piperidine ring substituted with a methyl group at the nitrogen and a hydroxyl group at the 4-position, serves as a critical intermediate in synthetic chemistry. Its molecular formula, C₆H₁₃NO, and molecular weight of 115.17 g/mol make it a lightweight yet functionally dense compound. Researchers often explore its solubility in polar solvents, boiling point (≈220°C), and hydrogen-bonding capacity, which are pivotal for drug formulation and material science applications.

In recent years, the demand for 1-Methylpiperidin-4-ol derivatives has surged, driven by their role in designing central nervous system (CNS) therapeutics. The compound’s piperidine scaffold mimics bioactive alkaloids, making it a hotspot for neurological drug discovery. Google Trends data reveals growing searches for "piperidine-based drug synthesis" and "CAS 106-52-5 suppliers," reflecting industry interest. Environmental concerns also spur innovations in green synthesis methods for such intermediates, aligning with the sustainable chemistry movement.

From a commercial perspective, 1-Methylpiperidin-4-ol is cataloged by major chemical suppliers under synonyms like N-Methyl-4-hydroxypiperidine or 4-Hydroxy-N-methylpiperidine. Its applications span chiral auxiliaries, ligands for catalysis, and precursors for agrochemicals. Analytical techniques like GC-MS and HPLC are routinely employed to verify its purity, a key concern for buyers. Discussions on platforms like ResearchGate often highlight its stability under inert conditions and compatibility with Grignard reagents, addressing common user queries.

The compound’s safety profile is another focal point. While not classified as hazardous, proper handling guidelines—such as using personal protective equipment (PPE)—are emphasized in SDS documents. Regulatory compliance, including REACH and FDA guidelines, ensures its safe use in GMP-certified facilities. This aligns with search trends for "non-toxic piperidine analogs" and "106-52-5 safety data," underscoring user priorities.

Emerging trends also link 1-Methylpiperidin-4-ol to bioorthogonal chemistry, where its modifiable hydroxyl group enables click chemistry applications. Patent filings reveal its incorporation in prodrug designs and bioconjugation, areas gaining traction in oncology research. Such advancements respond to searches like "piperidine in targeted drug delivery" and "CAS 106-52-5 patents," demonstrating its cross-disciplinary relevance.

In conclusion, 1-Methylpiperidin-4-ol (CAS No. 106-52-5) exemplifies the synergy between structural simplicity and functional diversity. Its role in pharmaceutical innovation, catalysis, and sustainable practices positions it as a compound of enduring scientific and industrial value. As research evolves, its applications will likely expand, further solidifying its niche in modern chemistry.

• 1189499-82-8(1-Methyl-4-hydroxypiperidine-d4)
• 117205-22-8(Piperidinium, 4-hydroxy-1,1-dimethyl-, chloride)
• 32235-52-2(4-Piperidinol,1-methyl-, conjugate acid (1:1))
• 4608-78-0(1-(3-Aminopropyl)piperidin-4-ol)
• 3518-83-0(N-Ethyl-4-hydroxypiperidine)
• 129999-60-6(1-(2-Aminoethyl)piperidin-4-ol)
• 224431-84-9(1-Piperidineethanol,4-hydroxy-)
• 105409-83-4(1-Propylpiperidin-4-ol)
• 32465-43-3(Piperidinium,4-hydroxy-1,1-dimethyl-)
• 5570-78-5(1-Isopropylpiperidin-4-ol)