• 1. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 2. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
  Chem. Commun., 1997, 767-768
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 5. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

Comprehensive Overview of 4-Phenethylpyridin-3-amine (CAS No. 105973-92-0): Properties, Applications, and Research Insights

4-Phenethylpyridin-3-amine (CAS No. 105973-92-0) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural features. This pyridine derivative combines a phenethyl group with an amine functionality, making it a versatile intermediate for synthesizing bioactive molecules. Researchers are increasingly exploring its potential in drug discovery, particularly in targeting neurological and metabolic pathways. The compound's molecular formula (C13H14N2) and molecular weight (198.26 g/mol) align with its role as a building block for more complex structures.

In recent years, the demand for heterocyclic compounds like 4-Phenethylpyridin-3-amine has surged, driven by advancements in medicinal chemistry and biotechnology. A 2023 study highlighted its relevance in designing small-molecule inhibitors for enzymes involved in inflammatory responses. This aligns with growing public interest in "anti-inflammatory drug development" and "precision medicine," topics frequently searched in academic and industry forums. The compound's amine group also facilitates derivatization, enabling researchers to tailor its properties for specific applications.

From a synthetic perspective, CAS 105973-92-0 exhibits notable stability under ambient conditions, a critical factor for industrial-scale production. Analytical techniques such as HPLC and NMR spectroscopy confirm its high purity (>98%), meeting stringent requirements for pharmaceutical intermediates. Laboratories often inquire about "pyridine-based compound synthesis" or "amine-protection strategies," reflecting the compound's technical relevance. Its logP value (predicted at 2.1) suggests moderate lipophilicity, advantageous for blood-brain barrier penetration in CNS-targeted therapies.

The compound's crystal structure has been characterized through X-ray diffraction, revealing intermolecular hydrogen bonding patterns that influence its solubility profile. This data is invaluable for formulators addressing common challenges like "improving API bioavailability" – a trending topic in pharmaceutical SEO. While not classified as hazardous, proper laboratory handling protocols should be observed, including the use of gloves and eye protection during manipulation.

Emerging applications of 4-Phenethylpyridin-3-amine extend to material science, where its aromatic system contributes to conductive polymer development. Patent literature describes its incorporation into organic semiconductors for flexible electronics – a field generating substantial online searches related to "wearable technology materials." The compound's UV-Vis absorption spectrum (λmax ~270 nm) makes it suitable for photophysical studies, particularly in the context of "fluorescence probe design."

Quality control specifications for CAS 105973-92-0 typically include tests for residual solvents, heavy metals, and related substances, reflecting GMP standards. Suppliers frequently field questions about "HPLC purification methods for pyridine derivatives" or "scaling up amine-containing intermediates," indicating the compound's industrial significance. Regulatory databases show no restrictions, but researchers should consult regional guidelines for chemical safety assessments before application development.

In conclusion, 4-Phenethylpyridin-3-amine represents a compelling case study in structure-activity relationship optimization. Its dual functionality as both hydrogen bond donor and acceptor positions it as a valuable scaffold in fragment-based drug discovery – a methodology dominating current medicinal chemistry publications. As interest grows in "privileged structures for lead optimization" and "multi-target drug design," this compound's scientific footprint continues to expand across peer-reviewed journals and technical forums.

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