• 1. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 2. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 3. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 4. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 5. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines Pyridinylpiperazines

(S)-6-(3-Methylpiperazin-1-yl)nicotinonitrile: A Comprehensive Overview

The compound with CAS No. 1057682-03-7, commonly referred to as (S)-6-(3-Methylpiperazin-1-yl)nicotinonitrile, is a significant molecule in the field of organic chemistry and pharmacology. This compound has garnered attention due to its unique structural properties and potential applications in drug discovery and material science. In this article, we will delve into the structural characteristics, synthesis methods, biological activities, and recent advancements related to this compound.

Structural Insights: The molecular structure of (S)-6-(3-Methylpiperazin-1-yl)nicotinonitrile is characterized by a nicotinonitrile core, which is a derivative of nicotinic acid. The piperazine ring, a six-membered ring containing two nitrogen atoms, is substituted at the 3-position with a methyl group. This substitution introduces steric and electronic effects that can influence the compound's reactivity and bioavailability. The stereochemistry at the chiral center (denoted by the (S) configuration) plays a crucial role in determining the compound's pharmacokinetic properties and interactions with biological targets.

Synthesis and Characterization: The synthesis of (S)-6-(3-Methylpiperazin-1-yl)nicotinonitrile involves a multi-step process that typically includes nucleophilic substitution, cyclization, and stereochemical control. Recent advancements in asymmetric synthesis have enabled the efficient preparation of this compound with high enantiomeric excess. Techniques such as high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy are commonly employed to characterize the purity and structure of the compound.

Biological Activity: (S)-6-(3-Methylpiperazin-1-yl)nicotinonitrile has demonstrated promising biological activity in various assays. Studies have shown that this compound exhibits potent inhibitory effects on key enzymes involved in metabolic pathways, making it a potential candidate for drug development. Additionally, its ability to modulate receptor activity suggests applications in treating conditions such as inflammation, neurodegenerative diseases, and cancer.

Applications in Drug Discovery: The unique combination of structural features in (S)-6-(3-Methylpiperazin-1-yl)nicotinonitrile makes it an attractive lead compound for drug discovery programs. Its ability to cross cellular membranes and interact with target proteins highlights its potential as an orally bioavailable drug candidate. Recent research has focused on optimizing its pharmacokinetic profile to enhance its efficacy and reduce off-target effects.

Recent Research Advances: In recent years, there has been a surge in research activities involving (S)-6-(3-Methylpiperazin-1-yl)nicotinonitrile. Scientists have explored its role in epigenetic regulation, where it has shown potential as an inhibitor of histone deacetylases (HDACs). Furthermore, studies have investigated its use as a building block for constructing more complex molecular architectures, paving the way for novel therapeutic agents.

Conclusion: (S)-6-(3-Methylpiperazin-1-yl)nicotinonitrile, with CAS No. 1057682-03-7, stands as a testament to the ingenuity of modern organic chemistry. Its versatile structure and promising biological properties continue to drive innovative research across multiple disciplines. As advancements in synthetic methodologies and biological screening techniques unfold, this compound is poised to play an increasingly important role in the development of next-generation therapeutics.

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