• 1. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
  Chem. Commun., 1997, 767-768
• 2. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 3. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 4. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 5. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indoles

Professional Introduction to 7-methyl-4-nitro-1H-indole (CAS No. 10553-07-8)

7-methyl-4-nitro-1H-indole, identified by its Chemical Abstracts Service number CAS No. 10553-07-8, is a significant compound in the field of pharmaceutical chemistry and bioorganic synthesis. This heterocyclic aromatic molecule has garnered considerable attention due to its versatile structural framework and potential applications in medicinal chemistry. The presence of both a methyl group and a nitro group on the indole ring imparts unique electronic and steric properties, making it a valuable intermediate in the development of various pharmacological agents.

The compound’s 7-methyl-4-nitro-1H-indole structure is characterized by a benzene ring fused to a pyrrole ring, with specific functional groups attached at the 4-position and 7-position. The nitro group at the 4-position enhances the molecule’s reactivity, allowing for further functionalization through reduction or nucleophilic substitution reactions. Meanwhile, the methyl group at the 7-position contributes to steric hindrance and can influence the compound’s metabolic stability and bioavailability.

In recent years, researchers have been exploring the 7-methyl-4-nitro-1H-indole as a precursor in the synthesis of bioactive molecules. Its indole core is a common motif in many natural products and drug candidates, including those targeting neurological disorders, infectious diseases, and cancer. For instance, studies have demonstrated its utility in constructing more complex scaffolds that mimic known pharmacophores responsible for therapeutic activity.

One of the most compelling aspects of 7-methyl-4-nitro-1H-indole is its role in developing novel antimicrobial agents. The nitro group’s ability to engage in redox reactions makes it an attractive feature for designing compounds that can disrupt bacterial cell wall synthesis or interfere with essential metabolic pathways. Recent publications highlight its incorporation into libraries of small molecules screened for antibacterial activity, showing promising results against resistant strains of pathogens.

The compound also finds relevance in the field of material science, particularly as a building block for organic semiconductors and light-emitting diodes (OLEDs). The electron-withdrawing nature of the nitro group enhances charge transport properties, making 7-methyl-4-nitro-1H-indole a candidate for optimizing electronic devices. Researchers have reported its use in synthesizing π-conjugated polymers that exhibit improved thermal stability and luminescence characteristics.

The synthesis of 7-methyl-4-nitro-1H-indole typically involves nitration of methylindole derivatives or alternative pathways that introduce both functional groups efficiently. Advances in catalytic methods have enabled greener synthetic routes, reducing waste and improving yields. These developments align with global efforts to promote sustainable chemistry practices in pharmaceutical manufacturing.

In conclusion, 7-methyl-4-nitro-1H-indole (CAS No. 10553-07-8) represents a multifaceted compound with broad applications across multiple scientific disciplines. Its unique structural features make it an indispensable tool for medicinal chemists seeking novel drug candidates, while its electronic properties are exploited in advanced materials engineering. As research continues to uncover new possibilities for this molecule, its significance in both academic and industrial settings is expected to grow.

• 25076-57-7(Quinoline,8-methyl-4-nitro-)
• 82212-22-4(8-nitroellipticine)
• 1190314-35-2(5,7-Dimethyl-4-nitro indole)
• 61149-54-0(5-Methyl-4-nitro-1H-indole)
• 133053-76-6(3-Methyl-6-nitro-1H-indole)
• 880086-93-1(6-Methyl-4-nitro indole)
• 91138-09-9(quinoline, 8-ethyl-5-nitro-)
• 103754-53-6(3-Methyl-5-nitroquinoline)
• 116529-86-3(8-Methyl-6-nitroquinoline)
• 64976-62-1(8-Methyl-5-nitroquinoline)