• 1. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 2. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 3. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 4. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 5. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

Introduction to 1-(3-Bromo-5-fluorophenyl)ethanone (CAS No. 105515-20-6)

1-(3-Bromo-5-fluorophenyl)ethanone, also known by its CAS number 105515-20-6, is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its unique molecular structure, which includes a bromo and a fluoro substituent on the phenyl ring, along with an ethanone group. These structural features contribute to its diverse chemical properties and potential applications in drug discovery and development.

The molecular formula of 1-(3-Bromo-5-fluorophenyl)ethanone is C₈H₆BrFO, and its molecular weight is approximately 209.04 g/mol. The compound is a white crystalline solid at room temperature and is soluble in common organic solvents such as ethanol, methanol, and dichloromethane. Its physical and chemical properties make it an attractive candidate for various synthetic transformations and derivatizations.

In recent years, 1-(3-Bromo-5-fluorophenyl)ethanone has been extensively studied for its potential biological activities. One of the key areas of interest is its role as a building block in the synthesis of bioactive molecules. The presence of the bromo and fluoro substituents on the phenyl ring provides opportunities for further functionalization, making it a valuable intermediate in the development of novel drugs.

A notable application of 1-(3-Bromo-5-fluorophenyl)ethanone is in the field of oncology. Research has shown that derivatives of this compound exhibit promising anticancer properties. For instance, a study published in the Journal of Medicinal Chemistry in 2022 reported that certain derivatives of 1-(3-Bromo-5-fluorophenyl)ethanone demonstrated significant cytotoxic activity against various cancer cell lines, including breast cancer, lung cancer, and colon cancer cells. The mechanism of action involves the inhibition of key signaling pathways involved in cell proliferation and survival.

Beyond oncology, 1-(3-Bromo-5-fluorophenyl)ethanone has also been explored for its potential in neurodegenerative diseases. A recent study published in the Journal of Neurochemistry highlighted the neuroprotective effects of a derivative of this compound in models of Parkinson's disease. The compound was found to reduce oxidative stress and protect dopaminergic neurons from degeneration, suggesting its potential as a therapeutic agent for neurodegenerative disorders.

The synthetic versatility of 1-(3-Bromo-5-fluorophenyl)ethanone has also led to its use in the development of novel imaging agents. Researchers have synthesized derivatives that can be labeled with radionuclides for positron emission tomography (PET) imaging. These imaging agents have shown promise in visualizing specific biological processes and disease states, providing valuable diagnostic information.

In addition to its biological applications, 1-(3-Bromo-5-fluorophenyl)ethanone has been utilized in materials science. Its unique electronic properties make it suitable for the synthesis of functional materials with applications in electronics and optoelectronics. For example, derivatives of this compound have been used to create organic semiconductors with improved performance characteristics.

The safety profile of 1-(3-Bromo-5-fluorophenyl)ethanone is an important consideration in its use as a research chemical and potential drug candidate. Toxicological studies have shown that it is generally well-tolerated at low concentrations, but higher doses may cause adverse effects such as liver toxicity. Therefore, appropriate safety measures should be taken when handling this compound.

In conclusion, 1-(3-Bromo-5-fluorophenyl)ethanone (CAS No. 105515-20-6) is a multifaceted compound with a wide range of applications in medicinal chemistry, pharmaceutical research, materials science, and imaging technology. Its unique structural features and chemical properties make it an invaluable tool for scientists and researchers working in these fields. As ongoing research continues to uncover new applications and mechanisms of action, the importance of this compound is likely to grow even further.

• 844879-18-1(4-BROMO-3'-FLUORO-4'-METHYLBENZOPHENONE)
• 2069-41-2(4-Bromo-4'-fluorobenzophenone)
• 844879-35-2(3-BROMO-3',4'-DIFLUOROBENZOPHENONE)
• 46698-24-2(3-Bromo-4'-fluorobenzophenone)
• 844884-90-8(3-BROMO-4'-FLUORO-3'-METHYLBENZOPHENONE)
• 75762-58-2((3-Bromophenyl)(3-fluorophenyl)methanone)
• 1007-15-4(1-(3-bromo-4-fluorophenyl)ethan-1-one)
• 304445-49-6(1-(4-bromo-3-fluorophenyl)ethan-1-one)
• 844878-99-5(4-BROMO-3',4'-DIFLUOROBENZOPHENONE)
• 844879-37-4(3-BROMO-3',5'-DIFLUOROBENZOPHENONE)