• 1. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 2. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 3. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 4. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 5. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

Comprehensive Overview of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-ylamino)ethanol (CAS No. 1053656-91-9)

2-(3-Chloro-5-(trifluoromethyl)pyridin-2-ylamino)ethanol (CAS No. 1053656-91-9) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural properties. This compound features a pyridine core substituted with chloro and trifluoromethyl groups, coupled with an ethanolamine side chain, making it a versatile intermediate for synthesizing bioactive molecules. Researchers are particularly interested in its potential applications in drug discovery, given the increasing demand for trifluoromethylated compounds and heterocyclic building blocks in modern medicinal chemistry.

The compound's molecular structure, characterized by the presence of a 3-chloro-5-(trifluoromethyl)pyridin-2-yl moiety, contributes to its reactivity and binding affinity in biological systems. This aligns with current trends in the pharmaceutical industry, where fluorinated pyridines are widely explored for their enhanced metabolic stability and lipophilicity. A growing number of studies focus on optimizing the synthesis of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-ylamino)ethanol to improve yield and purity, addressing common challenges such as regioselectivity and byproduct formation.

In agrochemical applications, CAS No. 1053656-91-9 serves as a key precursor for developing novel pesticides and herbicides. The trifluoromethyl group is known to enhance the bioactivity of agrochemicals, a feature that aligns with the industry's push for sustainable crop protection solutions. Recent advancements in green chemistry have also spurred interest in eco-friendly synthesis routes for this compound, catering to the global demand for environmentally friendly chemicals.

From a technical perspective, the compound's solubility, stability, and compatibility with other reagents are critical factors for its utility in multi-step syntheses. Analytical techniques such as HPLC, NMR, and mass spectrometry are routinely employed to characterize 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-ylamino)ethanol, ensuring compliance with stringent quality standards. These methods are frequently discussed in forums and publications, reflecting the compound's relevance in high-throughput screening and structure-activity relationship (SAR) studies.

The growing popularity of fluorinated heterocycles in drug design has further elevated the importance of this compound. For instance, its derivatives are being investigated for their potential in treating central nervous system (CNS) disorders and infectious diseases, topics that dominate recent scientific literature. Additionally, the compound's role in catalysis and material science is an emerging area of research, with studies exploring its use in metal-organic frameworks (MOFs) and polymer modification.

In summary, 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-ylamino)ethanol (CAS No. 1053656-91-9) represents a critical building block in both pharmaceutical and agrochemical industries. Its structural versatility, combined with the rising demand for fluorinated compounds, positions it as a focal point for innovation. As research continues to uncover new applications, this compound is poised to play a pivotal role in addressing some of the most pressing challenges in life sciences and sustainable chemistry.

• 1157109-01-7(2-{3-Chloro-5-(trifluoromethyl)-2-pyridinylamino}-2-methyl-1-propanol)
• 219478-19-0(N1-3-chloro-5-(trifluoromethyl)pyridin-2-ylethane-1,2-diamine)
• 263387-09-3(2-3-Chloro-5-(trifluoromethyl)-2-pyridinyl(methyl)amino-1-ethanol)
• 1031619-96-1(N-3-Chloro-5-(trifluoromethyl)-2-pyridinyl-N-cyclopropylamine)
• 1036436-75-5(3-Chloro-N-isopropyl-5-(trifluoromethyl)-2-pyridinamine)
• 465514-63-0(n-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]propane-1,3-diamine)
• 215434-40-5(2-{4-3-Chloro-5-(trifluoromethyl)-2-pyridinylpiperazino}-1-ethanol)
• 1220033-21-5(2-3-Chloro-5-(trifluoromethyl)-2-pyridinyl-(ethyl)amino-1-ethanol)
• 338966-48-6(4-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]amino}-3-hydroxybuta Nenitrile)
• 338761-50-5(N-Allyl-3-chloro-5-(trifluoromethyl)pyridin-2-amine)