• 1. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 2. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 3. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
• 4. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 5. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210

Comprehensive Overview of 2-Bromo-1-(5-phenyl-2-thienyl)-1-ethanone (CAS No. 10531-43-8): Properties, Applications, and Industry Insights

2-Bromo-1-(5-phenyl-2-thienyl)-1-ethanone (CAS No. 10531-43-8) is a specialized organic compound that has garnered significant attention in pharmaceutical and material science research. This brominated ketone derivative features a unique molecular structure combining a thiophene ring with a phenyl group, making it valuable for synthesizing complex heterocyclic compounds. Its molecular formula C12H9BrOS and precise chemical properties have been extensively documented in peer-reviewed journals, particularly for applications in medicinal chemistry and organic synthesis.

Recent trends in drug discovery highlight the growing demand for thiophene-based intermediates like 2-Bromo-1-(5-phenyl-2-thienyl)-1-ethanone. Researchers frequently search for "synthetic routes for brominated thienyl ketones" or "CAS 10531-43-8 solubility data," reflecting its importance in developing kinase inhibitors and antiviral agents. The compound's crystallographic data (available in Cambridge Structural Database) reveals a planar configuration that facilitates π-π stacking interactions, a feature exploited in small molecule drug design.

From a material science perspective, this compound serves as a precursor for conductive polymers and organic semiconductors. Industry reports show increased searches for "thiophene derivatives for OLEDs" and "10531-43-8 thermal stability," aligning with the push for flexible electronics. The bromine substituent at the alpha position enables efficient cross-coupling reactions, particularly in palladium-catalyzed transformations used to construct π-conjugated systems.

Analytical studies of CAS 10531-43-8 reveal optimal HPLC purification methods (>98% purity achievable with C18 reverse-phase columns) and storage conditions (recommended at 2-8°C under inert atmosphere). Safety data sheets emphasize standard laboratory handling protocols, while patent literature demonstrates its utility in photoredox catalysis systems – a hot topic in green chemistry discussions.

The commercial availability of 2-Bromo-1-(5-phenyl-2-thienyl)-1-ethanone through major chemical suppliers has expanded significantly since 2020, with market analysts noting 23% annual growth in specialty ketone demand. This correlates with rising Google search volumes for "buy 10531-43-8" and "thienyl ketone suppliers." Current research explores its potential in bioconjugation chemistry, particularly for developing fluorescent probes used in biological imaging.

Environmental considerations regarding brominated compounds have led to innovations in waste treatment protocols for 10531-43-8. Recent publications describe advanced oxidation processes for byproduct degradation, addressing sustainability concerns frequently raised in pharmaceutical manufacturing forums. The compound's structure-activity relationships continue to be investigated through computational chemistry approaches, with particular interest in its electrostatic potential maps for molecular docking studies.

Emerging applications in agrochemical research utilize 2-Bromo-1-(5-phenyl-2-thienyl)-1-ethanone as a building block for crop protection agents, evidenced by patent filings from major agricultural chemical companies. This development corresponds with increased searches for "thiophene pesticides" and "heterocyclic agrochemicals." Analytical techniques like LC-MS and NMR spectroscopy provide reliable characterization data, crucial for quality control in scale-up production.

Academic laboratories frequently employ CAS 10531-43-8 in multicomponent reactions, with recent literature highlighting its role in synthesizing polycyclic aromatic systems. The compound's reaction kinetics have been modeled using density functional theory (DFT), yielding insights into its nucleophilic substitution behavior. These findings address common researcher queries about "thienyl ketone reactivity" and "bromine leaving group efficiency."

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)