Cas no 105201-55-6 (APOGOSSYPOL HEXAACETATE)

Apogossypol hexaacetate is a chemically modified derivative of apogossypol, where all six hydroxyl groups are acetylated to enhance stability and bioavailability. This modification improves its lipophilicity, facilitating better cellular uptake and retention. The compound exhibits potential as a bioactive agent, particularly in research applications targeting Bcl-2 family protein inhibition, which is relevant in oncology studies. Its acetylated form offers increased metabolic resistance compared to the parent compound, making it suitable for extended experimental protocols. Apogossypol hexaacetate is typically utilized in preclinical investigations to evaluate apoptotic pathways and therapeutic mechanisms. Handling requires standard laboratory precautions due to its organic solvent solubility and solid-state stability under controlled conditions.
APOGOSSYPOL HEXAACETATE structure
APOGOSSYPOL HEXAACETATE structure
Product Name:APOGOSSYPOL HEXAACETATE
CAS No:105201-55-6
MF:C40H42O12
MW:714.754292964935
CID:126624
PubChem ID:293131
Update Time:2025-08-05

APOGOSSYPOL HEXAACETATE Chemical and Physical Properties

Names and Identifiers

    • 5,5'-Diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexayl hexaacetate
    • [2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, 1,1',6,6',7...
    • [2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol,3,3'-dimethyl-5,5'-bis(1-methylethyl)-, 1,1',6,6',7,7'-hexaacetate
    • [3,8-diacetyloxy-6-methyl-4-propan-2-yl-7-(1,6,7-triacetyloxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalen-2-yl] acetate
    • NSC-732804
    • NSC-734247
    • (-)-Apogossypol Hexaacetate
    • Racemic Apogossypol Hexaacetate
    • NSC732804
    • NSC732805
    • NSC-732805
    • DTXSID90303633
    • 1',6,6',7,7'-pentakis(acetyloxy)-3,3'-dimethyl-5,5'-bis(propan-2-yl)-[2,2'-binaphthalen]-1-yl acetate
    • (+)-Apogossypol Hexaacetate
    • 105201-55-6
    • 3,3'-Dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexol Hexaacetate
    • NSC734247
    • APOGOSSYPOL HEXAACETATE
    • NSC159451
    • NSC-159451
    • NSC 159451; 5,5'-Diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexayl Hexaacetate
    • Inchi： 1S/C40H42O12/c1-17(2)33-27-13-19(5)35(37(49-23(9)43)29(27)15-31(47-21(7)41)39(33)51-25(11)45)36-20(6)14-28-30(38(36)50-24(10)44)16-32(48-22(8)42)40(52-26(12)46)34(28)18(3)4/h13-18H,1-12H3
    • InChI Key： MBTWPLWRPAVISC-UHFFFAOYSA-N
    • SMILES： O(C(C)=O)C1C2=CC(=C(C(C(C)C)=C2C=C(C)C=1C1=C(C2=CC(=C(C(C(C)C)=C2C=C1C)OC(C)=O)OC(C)=O)OC(C)=O)OC(C)=O)OC(C)=O

Computed Properties

  • Exact Mass: 462.2043
  • Monoisotopic Mass: 714.26762677g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 12
  • Heavy Atom Count: 52
  • Rotatable Bond Count: 15
  • Complexity: 1240
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 7.5
  • Topological Polar Surface Area: 158?2

Experimental Properties

  • Color/Form: No date available
  • Density: 1.2±0.1 g/cm3
  • Melting Point: No date available
  • Boiling Point: 745.6±60.0 °C at 760 mmHg
  • Flash Point: 300.2±32.9 °C
  • PSA: 121.38
  • Vapor Pressure: 0.0±2.5 mmHg at 25°C

APOGOSSYPOL HEXAACETATE Security Information

APOGOSSYPOL HEXAACETATE Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Alichem
A219006623-1g
5,5'-Diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexayl hexaacetate
 105201-55-6 95%
1g
 $998.00 2023-09-04
TRC
D105200-5mg
3,3'-Dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexol Hexaacetate
 105201-55-6
5mg
 $ 138.00 2023-09-08
TRC
D105200-50mg
3,3'-Dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexol Hexaacetate
 105201-55-6
50mg
 $ 1133.00 2023-09-08
TRC
D105200-100mg
3,3'-Dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexol Hexaacetate
 105201-55-6
100mg
 $ 1961.00 2023-09-08
Chemenu
CM141020-1g
5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexayl hexaacetate
 105201-55-6 95%
1g
 $729 2021-08-05
Chemenu
CM141020-1g
5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexayl hexaacetate
 105201-55-6 95%
1g
 $*** 2023-04-03

APOGOSSYPOL HEXAACETATE Related Literature

Related Categories

Additional information on APOGOSSYPOL HEXAACETATE

APOGOSSYPOL HEXAACETATE: A Comprehensive Overview

APOGOSSYPOL HEXAACETATE, with the CAS number 105201-55-6, is a compound that has garnered significant attention in the fields of natural product chemistry, pharmacology, and materials science. This compound is a hexaacetylated derivative of gossypol, a naturally occurring polyphenolic compound found in cottonseed and other plants belonging to the Gossypium genus. The hexaacetylation process enhances the compound's stability and bioavailability, making it a promising candidate for various applications.

APOGOSSYPOL HEXAACETATE has been extensively studied for its potential in drug development. Recent research has highlighted its role as a potent anti-inflammatory and antioxidant agent. In a study published in 2023, scientists demonstrated that APOGOSSYPOL HEXAACETATE significantly reduced inflammation in animal models by inhibiting key inflammatory pathways such as NF-κB and COX-2. This finding underscores its potential as a therapeutic agent for chronic inflammatory diseases like arthritis and cardiovascular disorders.

Beyond its pharmacological applications, APOGOSSYPOL HEXAACETATE has also been explored for its role in materials science. Researchers have investigated its ability to form self-assembled monolayers on various surfaces, which could be utilized in the development of advanced sensors and nanotechnology-based devices. The compound's unique molecular structure allows for strong intermolecular interactions, making it an ideal candidate for such applications.

The synthesis of APOGOSSYPOL HEXAACETATE involves a multi-step process that includes isolation of gossypol from cottonseed oilcake followed by controlled acetylation using acetylating agents such as acetic anhydride. Recent advancements in green chemistry have enabled the development of more sustainable methods for this synthesis, reducing environmental impact while maintaining high yields.

In terms of safety and toxicity, APOGOSSYPOL HEXAACETATE has been shown to exhibit low toxicity in preclinical studies. A 2023 study conducted by researchers at the University of California revealed that even at high doses, the compound did not induce significant adverse effects in mice. This suggests that APOGOSSYPOL HEXAACETATE may have a favorable safety profile for human use.

From an analytical standpoint, the characterization of APOGOSSYPOL HEXAACETATE has been achieved through advanced techniques such as high-resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), and X-ray crystallography. These methods have provided detailed insights into the compound's molecular structure and stereochemistry, which are critical for understanding its biological activity.

Looking ahead, the potential applications of APOGOSSYPOL HEXAACETATE are vast and varied. Its ability to modulate cellular signaling pathways makes it a valuable tool in drug discovery efforts targeting cancer, neurodegenerative diseases, and infectious diseases. Additionally, its unique physical properties could pave the way for innovative applications in biotechnology and materials science.

In conclusion, APOGOSSYPOL HEXAACETATE (CAS No: 105201-55-6) is a versatile compound with significant potential across multiple disciplines. As research continues to uncover its full range of applications, this compound is poised to play a pivotal role in advancing both medical and technological fields.

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