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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Dialkyl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Dialkyl ethers

Research Brief on 2-Methoxy-1-butanamine hydrochloride (CAS: 1050509-60-8): Recent Advances and Applications

2-Methoxy-1-butanamine hydrochloride (CAS: 1050509-60-8) is a chemical compound of significant interest in the field of chemical biology and pharmaceutical research. This compound, characterized by its methoxy and butylamine functional groups, has recently garnered attention due to its potential applications in drug discovery and development. Recent studies have explored its role as a building block in the synthesis of novel therapeutic agents, particularly in the context of central nervous system (CNS) disorders and antimicrobial therapies.

A 2023 study published in the Journal of Medicinal Chemistry highlighted the use of 2-Methoxy-1-butanamine hydrochloride as a key intermediate in the synthesis of serotonin receptor modulators. The research demonstrated that derivatives of this compound exhibit high affinity for 5-HT_2A receptors, suggesting potential applications in the treatment of psychiatric disorders such as schizophrenia and depression. The study employed molecular docking simulations and in vitro binding assays to validate the compound's interactions with target receptors, providing a robust foundation for further preclinical development.

In addition to its CNS applications, 2-Methoxy-1-butanamine hydrochloride has been investigated for its antimicrobial properties. A recent preprint on bioRxiv (2024) reported that this compound, when incorporated into quaternary ammonium derivatives, exhibits broad-spectrum activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The mechanism of action appears to involve disruption of bacterial cell membranes, as evidenced by electron microscopy and fluorescence-based membrane integrity assays. These findings open new avenues for the development of next-generation antimicrobial agents.

From a synthetic chemistry perspective, advances in the scalable production of 2-Methoxy-1-butanamine hydrochloride have been achieved through continuous flow chemistry techniques. A 2024 Organic Process Research & Development paper detailed an optimized protocol that reduces reaction times by 60% while maintaining high yields (>85%) and purity (>99%). This methodological improvement addresses previous challenges in large-scale synthesis, making the compound more accessible for industrial applications.

The compound's physicochemical properties have also been characterized in recent computational studies. Density functional theory (DFT) calculations published in Computational and Theoretical Chemistry (2023) provided insights into its conformational preferences and electronic structure, which are crucial for understanding its reactivity in various synthetic pathways. These computational models align well with experimental NMR data, validating their predictive utility for future derivative design.

Looking forward, the versatility of 2-Methoxy-1-butanamine hydrochloride continues to inspire innovative research directions. Current clinical trials (Phase I) are investigating its derivatives as potential analgesics with reduced opioid-like side effects. Furthermore, its application in materials science is emerging, with preliminary studies showing promise as a monomer for functional polymer synthesis. As research progresses, this compound is poised to make significant contributions across multiple domains of chemical biology and pharmaceutical development.

• 869891-27-0(1,4-Butanediamine, 2-ethoxy-, (2R)-)
• 885331-26-0([(2R)-tetrahydropyran-2-yl]methanamine)
• 869891-26-9(1,4-Butanediamine, 2-ethoxy-, (2S)-)
• 89585-14-8(2-ethoxybutan-1-amine)
• 683233-12-7(1-(oxan-2-yl)methanamine hydrochloride)
• 21801-94-5((2S)-Tetrahydro-2-furanmethanamine Hydrochloride)
• 1262771-60-7((2-ethoxybutyl)amine hydrochloride)
• 89282-64-4(2-Methoxy-butylamine)
• 869891-25-8(1,4-Butanediamine, 2-methoxy-, (2R)-)
• 869891-24-7(1,4-Butanediamine, 2-methoxy-, (2S)-)