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  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 2. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acids

4-(2-Amino-ethoxy)-benzoic acid hydrochloride (CAS No. 1050208-10-0): An Overview

4-(2-Amino-ethoxy)-benzoic acid hydrochloride (CAS No. 1050208-10-0) is a versatile compound with significant applications in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as 4-(2-Aminoethoxy)benzoic acid hydrochloride, is a derivative of benzoic acid and features an aminoethoxy functional group. Its unique chemical structure and properties make it a valuable intermediate in the synthesis of various pharmaceuticals and biologically active molecules.

The molecular formula of 4-(2-Amino-ethoxy)-benzoic acid hydrochloride is C₉H₁₁NO₃·HCl, and its molecular weight is approximately 213.64 g/mol. The compound is typically supplied as a white to off-white crystalline powder with a melting point ranging from 195 to 198°C. It is highly soluble in water and polar organic solvents, making it suitable for various chemical reactions and analytical techniques.

In recent years, 4-(2-Amino-ethoxy)-benzoic acid hydrochloride has gained attention due to its potential therapeutic applications. One of the key areas of research involves its use as an intermediate in the synthesis of antidepressants and anxiolytics. The aminoethoxy group in the molecule can be readily modified to introduce additional functional groups, enhancing its pharmacological properties and selectivity.

A study published in the *Journal of Medicinal Chemistry* in 2023 highlighted the role of 4-(2-Amino-ethoxy)-benzoic acid hydrochloride in the development of novel serotonin reuptake inhibitors (SRIs). These inhibitors are crucial for treating mood disorders such as depression and anxiety by modulating serotonin levels in the brain. The researchers found that derivatives of this compound exhibited high binding affinity to serotonin transporters, suggesting their potential as lead compounds for further drug development.

Beyond its applications in psychiatric disorders, 4-(2-Amino-ethoxy)-benzoic acid hydrochloride has also shown promise in the field of cancer research. A study conducted by a team at the National Cancer Institute demonstrated that certain derivatives of this compound could inhibit the growth of cancer cells by targeting specific signaling pathways involved in cell proliferation and apoptosis. These findings open up new avenues for developing targeted therapies against various types of cancer.

In addition to its therapeutic potential, 4-(2-Amino-ethoxy)-benzoic acid hydrochloride is also used as a building block in the synthesis of fluorescent probes and sensors. The presence of the amino group allows for easy conjugation with fluorescent dyes or other functional molecules, making it useful for imaging applications in biological systems. This property has been leveraged in studies aimed at understanding cellular processes at the molecular level.

The safety profile of 4-(2-Amino-ethoxy)-benzoic acid hydrochloride is an important consideration for its use in pharmaceutical applications. Preclinical studies have shown that it exhibits low toxicity and good biocompatibility when administered at therapeutic doses. However, as with any chemical compound, proper handling and storage precautions should be followed to ensure safety and efficacy.

In conclusion, 4-(2-Amino-ethoxy)-benzoic acid hydrochloride (CAS No. 1050208-10-0) is a multifaceted compound with a wide range of applications in medicinal chemistry, pharmaceutical research, and biotechnology. Its unique chemical structure and versatile reactivity make it an invaluable tool for scientists working on the development of new drugs and diagnostic tools. As research continues to uncover new possibilities, this compound is likely to play an increasingly important role in advancing our understanding and treatment of various diseases.

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