• 1. Ordered liquids and hydrogels from alkenyl succinic ester terminated bola-amphiphiles for large-scale applications
  Thomas Lohmeier,Michael Bredol,Eduard Schreiner,Horst Hintze-Bruening Soft Matter 2014 10 6237
• 2. Molecular structure and polymorphism of a cyclohexanediol: trans-1,4-cyclohexanedimethanol
  Mário T. S. Rosado,Teresa M. R. Maria,Ricardo A. E. Castro,Jo?o Canotilho,Manuela Ramos Silva,M. Ermelinda S. Eusébio CrystEngComm 2014 16 10977
• 3. Intrinsic flame retardant phosphonate-based vitrimers as a recyclable alternative for commodity polymers in composite materials
  Jens C. Markwart,Alexander Battig,Tobias Urbaniak,Katharina Haag,Katharina Koschek,Bernhard Schartel,Frederik R. Wurm Polym. Chem. 2020 11 4933
• 4. Degradable polyprodrugs: design and therapeutic efficiency
  Farzad Seidi,Yajie Zhong,Huining Xiao,Yongcan Jin,Daniel Crespy Chem. Soc. Rev. 2022 51 6652
• 5. Poly(ethylene glycol-co-1,4-cyclohexanedimethanol terephthalate) random copolymers: effect of copolymer composition and microstructure on the thermal properties and crystallization behavior
  Tingting Chen,Guodong Jiang,Guoyu Li,Zhipeng Wu,Jun Zhang RSC Adv. 2015 5 60570

• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether
• Pharmaceutical and Biochemical Products Pharmaceutical Intermediates
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients

Professional Introduction to 1,4-Cyclohexanedimethanol (CAS No. 105-08-8)

1,4-Cyclohexanedimethanol, chemically designated as (2R,3S)-2,4-cyclohexanediol, is a significant compound in the realm of organic chemistry and pharmaceutical synthesis. With the CAS number 105-08-8, this bicyclic alcohol has garnered attention for its versatile applications in industrial and medicinal chemistry. Its unique structural framework, featuring two hydroxyl groups positioned at the 1 and 4 positions of a cyclohexane ring, imparts distinct chemical properties that make it a valuable intermediate in the production of polymers, resins, and pharmaceuticals.

The compound’s molecular formula, C?H??O?, reflects its composition of six carbon atoms, twelve hydrogen atoms, and two oxygen atoms. This arrangement contributes to its reactivity, allowing it to participate in various chemical reactions such as esterification, etherification, and oxidation. The presence of two stereocenters at the 2 and 3 positions of the cyclohexane ring results in the formation of two enantiomers, which can exhibit different biological activities. This stereochemical diversity has been a focal point in recent research aimed at developing enantioselective catalysts and chiral drugs.

In the pharmaceutical industry, 1,4-Cyclohexanedimethanol serves as a crucial precursor in the synthesis of several active pharmaceutical ingredients (APIs). Its diol functionality allows for the introduction of various pharmacophores through further functionalization. For instance, derivatives of this compound have been explored as intermediates in the production of non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents. The ability to modify its structure enables chemists to fine-tune the pharmacokinetic and pharmacodynamic properties of these drugs, enhancing their efficacy and reducing side effects.

Recent advancements in green chemistry have highlighted the importance of sustainable synthetic routes for 1,4-Cyclohexanedimethanol. Researchers have been investigating biocatalytic methods to produce this compound with higher yields and lower environmental impact. Enzymes such as cytochrome P450 monooxygenases have been employed to selectively oxidize cyclohexane derivatives into diols under mild conditions. These biocatalytic processes align with the growing demand for eco-friendly chemical manufacturing practices.

The polymer industry also benefits from the use of 1,4-Cyclohexanedimethanol as a monomer or chain extender in the production of polyesters and polyamides. Its bifunctional nature allows it to participate in polycondensation reactions, resulting in polymers with desirable mechanical and thermal properties. For example, polyethylene terephthalate (PET) can be modified by incorporating 1,4-Cyclohexanedimethanol into its backbone, improving its flexibility and biodegradability. Such modifications are particularly relevant in the context of developing sustainable packaging materials that reduce reliance on petroleum-based polymers.

Moreover, 1,4-Cyclohexanedimethanol has found applications in agrochemicals as a precursor for herbicides and fungicides. Its structural motif is compatible with various functional groups that enhance biological activity against pests and pathogens. By leveraging computational chemistry techniques such as molecular docking and quantum mechanical calculations, researchers can predict how different derivatives of this compound will interact with biological targets. This approach accelerates the discovery process for novel agrochemicals with improved performance.

The material science sector has also explored 1,4-Cyclohexanedimethanol for its potential in creating advanced materials with tailored properties. For instance, its incorporation into epoxy resins enhances their thermal stability and mechanical strength. Additionally, researchers have investigated its use in designing shape-memory polymers that can revert to predefined shapes upon exposure to external stimuli such as heat or light. These innovations underscore the compound’s versatility beyond traditional applications.

In conclusion,1,4-Cyclohexanedimethanol (CAS No. 105-08-8) is a multifaceted compound with broad utility across multiple industries. Its role as a synthetic intermediate in pharmaceuticals, polymers, agrochemicals, and advanced materials underscores its importance in modern chemistry. As research continues to uncover new applications and sustainable production methods for this compound,1,4-Cyclohexanedimethanol is poised to remain a cornerstone of innovation in both academic and industrial settings.

• 172342-28-8(2-[(1S,2S)-2-(Hydroxymethyl)cyclohexyl]ethan-1-ol)
• 88416-94-8(TRANS-4-(TRANS-4'-BUTYLCYCLOHEXYL)CYCLOHEXYLMETHANOL)
• 100705-13-3(1,2-Cyclohexanedimethanol, 3-methyl-)
• 82598-08-1(((Trans,Trans)-4'-Pentyl-1,1'-Bi(Cyclohexan)-4-Yl)Methanol)
• 1173022-09-7(dideuterio-[3-[dideuterio(hydroxy)methyl]cyclohexyl]methanol)
• 13844-62-7((S)-cis-p-Menthan-9-ol)
• 5113-95-1((S)-cis-p-Menthan-9-ol)
• 13746-24-2(Cyclohexanemethanol, 2-methyl-5-(1-methylethyl)-, (1R,2R,5S)-rel-)
• 1141487-54-8((R,S)-5-cyclohexyl-2-methyl-pentan-1-ol)
• 88416-93-7((反式,反式)-4'-乙基-[1,1'-聯(lián)環(huán)己烷]-4-甲醇)