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• 5. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles

1-(2-Chloroethyl)-4-methyl-1H-pyrazole: A Comprehensive Overview

The compound with CAS No. 1046861-53-3, commonly referred to as 1-(2-Chloroethyl)-4-methyl-1H-pyrazole, is a fascinating molecule that has garnered significant attention in the fields of organic chemistry and materials science. This compound is a derivative of the pyrazole family, which is known for its versatile applications in drug discovery, agrochemicals, and advanced materials. The structure of 1-(2-Chloroethyl)-4-methyl-1H-pyrazole consists of a pyrazole ring substituted with a 2-chloroethyl group at position 1 and a methyl group at position 4, making it a unique member of the pyrazole derivatives.

Recent studies have highlighted the potential of pyrazole derivatives in various biological and chemical systems. For instance, researchers have explored the role of pyrazole-containing compounds in modulating enzyme activity, particularly in the context of kinase inhibitors. The presence of the chloroethyl group in 1-(2-Chloroethyl)-4-methyl-1H-pyrazole introduces additional reactivity, making it a promising candidate for further exploration in medicinal chemistry.

In terms of synthesis, the preparation of 1-(2-Chloroethyl)-4-methyl-1H-pyrazole typically involves multi-step organic reactions. One common approach is the alkylation of pyrazole derivatives using appropriate alkylating agents. The methyl substitution at position 4 can be achieved through Friedel-Crafts alkylation or other similar methods, while the chloroethyl group is introduced via nucleophilic substitution or coupling reactions. These synthetic strategies not only highlight the versatility of pyrazole chemistry but also underscore the importance of precise control over reaction conditions to achieve high yields and purity.

The application of pyrazole derivatives extends beyond traditional pharmaceuticals. Recent advancements have demonstrated their utility in materials science, particularly in the development of coordination polymers and metal-organic frameworks (MOFs). The nitrogen atoms in the pyrazole ring can act as coordinating sites, enabling the formation of stable metal-ligand complexes. This property makes 1-(2-Chloroethyl)-4-methyl-1H-pyrazole a valuable building block for constructing functional materials with applications in gas storage, catalysis, and sensing technologies.

Beyond its chemical applications, pyrazole-containing compounds have also been studied for their environmental impact. Researchers are investigating their biodegradation pathways and potential toxicity to aquatic organisms. Understanding these aspects is crucial for ensuring sustainable practices in the synthesis and application of such compounds. Preliminary studies suggest that certain pyrazole derivatives exhibit moderate biodegradability under specific environmental conditions, but further research is needed to fully characterize their ecological footprint.

In conclusion, CAS No. 1046861-53-3, or 1-(2-Chloroethyl)-4-methyl-1H-pyrazole, represents a compelling example of how structural modifications can enhance the functionality and applicability of organic compounds. With ongoing research into its synthesis, properties, and applications, this compound continues to be a focal point for innovation across multiple disciplines.

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