• 1. Heteroleptic strontium complexes stabilized by donor-functionalized alkoxide and β-diketonate ligands
  Sheby Mary George,Hyo-Suk Kim,Hyun Ji Oh,Myoung Soo Lah,Dong Ju Jeon,Bo Keun Park,Jeong Hwan Han,Chang Gyoun Kim,Taek-Mo Chung Dalton Trans. 2015 44 14042

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Secondary amines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Comprehensive Overview of (2-Methoxyethyl)(propan-2-yl)amine (CAS No. 104678-18-4): Properties, Applications, and Industry Insights

(2-Methoxyethyl)(propan-2-yl)amine, with the CAS number 104678-18-4, is a versatile chemical compound widely utilized in pharmaceutical, agrochemical, and specialty chemical industries. This secondary amine derivative features a methoxyethyl group and an isopropyl moiety, offering unique reactivity and solubility properties. Its molecular structure (C6H15NO) makes it valuable for organic synthesis, particularly in the development of drug intermediates and catalysts.

The compound's boiling point (typically 150-160°C) and lipophilicity (logP ~0.8) make it suitable for formulations requiring controlled solubility. Recent studies highlight its role in green chemistry applications, aligning with the global shift toward sustainable synthesis methods. Researchers are exploring its potential in biodegradable surfactants, responding to the growing demand for eco-friendly chemicals in consumer products.

In pharmaceutical contexts, (2-methoxyethyl)(propan-2-yl)amine serves as a key building block for API synthesis. Its balanced polarity enables efficient molecular modifications, particularly in CNS-targeting drugs where blood-brain barrier penetration is critical. The compound's low toxicity profile (as per OECD 423 guidelines) further enhances its utility in preclinical development stages.

The agrochemical sector employs this amine in crop protection formulations, where its systemic activity improves pesticide delivery. Manufacturers are optimizing production processes to meet REACH compliance standards, addressing industry concerns about chemical safety and regulatory compliance. Advanced process analytical technology (PAT) now enables real-time monitoring during synthesis, reducing batch variability.

Material science applications leverage the compound's surface modification capabilities. Its amine functionality facilitates covalent bonding with polymers and nanomaterials, making it valuable for creating functional coatings. Recent patents describe its use in conductive inks for flexible electronics—a rapidly growing market driven by wearable technology demand.

Analytical characterization of CAS 104678-18-4 typically involves GC-MS, HPLC, and NMR spectroscopy. The compound shows distinct proton signals at 1.0 ppm (isopropyl CH3) and 3.3 ppm (methoxy CH3), with carbon-13 peaks between 45-65 ppm. These spectral features aid in quality control protocols, especially for GMP manufacturing applications.

Storage recommendations for (2-methoxyethyl)(propan-2-yl)amine emphasize nitrogen blanketing to prevent oxidation. Industry best practices suggest stainless steel or PTFE-lined containers for long-term storage, maintaining purity above 98%. These protocols align with ICH stability guidelines for chemical intermediates.

Emerging research explores the compound's potential in CO2 capture technologies. Its amine group demonstrates moderate carbon dioxide affinity in non-aqueous systems, sparking interest for post-combustion capture applications. This aligns with global carbon neutrality initiatives and the search for energy-efficient solvents.

Market analysts project steady growth for 104678-18-4 derivatives, driven by pharmaceutical outsourcing trends and Asia-Pacific manufacturing expansion. Quality benchmarks now require genotoxic impurity testing below 1 ppm, reflecting tightened regulatory standards worldwide. Suppliers are responding with enhanced analytical methodologies and certification programs.

From an environmental perspective, biodegradation studies indicate moderate persistence (OECD 301B), prompting development of advanced oxidation processes for wastewater treatment. The compound's environmental fate remains an active research area, particularly regarding metabolite formation in biological systems.

Technological advancements in continuous flow chemistry are revolutionizing production of 2-methoxyethyl isopropylamine. Microreactor systems achieve higher atom economy (>85%) compared to batch processes, reducing organic waste generation. These innovations support the circular economy model gaining traction across chemical industries.

Safety data sheets emphasize standard amine handling precautions—use of chemical goggles and nitrile gloves. The compound's vapor pressure (≈2 mmHg at 20°C) warrants adequate ventilation systems in industrial settings. These measures align with occupational health protocols for volatile organic compounds.

Future applications may exploit the compound's hydrogen bonding capacity for supramolecular chemistry applications. Preliminary studies suggest utility in molecular recognition systems and self-assembling materials—key areas in nanotechnology development. Such interdisciplinary potential underscores the importance of CAS 104678-18-4 in next-generation chemical innovations.

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