Cas no 104632-27-1 (Dexpramipexole dihydrochloride)
Dexpramipexole dihydrochloride is a synthetic small molecule belonging to the class of aminothiazole derivatives. It functions as a selective agonist for the dopamine D2 receptor subfamily, demonstrating neuroprotective and antioxidant properties. The dihydrochloride salt form enhances solubility and bioavailability, making it suitable for preclinical and clinical research applications. Its key advantages include high purity (>98%), stability under standard storage conditions, and well-documented pharmacokinetic profiles in animal models. The compound has been investigated for potential therapeutic applications in neurodegenerative disorders, particularly amyotrophic lateral sclerosis (ALS), due to its ability to modulate mitochondrial function and reduce oxidative stress. It is supplied as a white to off-white crystalline powder.
104632-27-1 structure
Product Name:Dexpramipexole dihydrochloride
CAS No:104632-27-1
MF:C10H19Cl2N3S
MW:284.248958826065
MDL:MFCD13186799
CID:820143
PubChem ID:329750929
Update Time:2025-06-07
Dexpramipexole dihydrochloride Chemical and Physical Properties
Names and Identifiers
-
- R-Pramipexole 2HCl
- 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, (R)-
- Kns 760704
- Snd 919cl2x
- Dexpramipexole dihydrochloride
- (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine,dihydrochloride
- (R)-Pramipexole (hydrochloride) NEW
- IMPURITY `D’ OF PRAMIPEXOLE
- Pramipexole Impurity D
- R-Pramipexole
- (-)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole dihydrochl
- (+)-2-amino-4,5,6,7-tetrahydro-6-L-propylaminobenzathiazole dihydrochloride
- (+)-2-amino-6-(propylamino)tetrahydrobenzothiazole dihydrochloride
- (+)-Pramipexole dihydrochloride
- (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride
- (R)-Pramipexole dihydrochloride
- 2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-,dihydrochloride,(R)
- Bio-0080
- CS-1195
- UNII-I9038PKO43
- (R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
- (R)-4,5,6,7-Tetrahydro-6-(propylamino)-benzothiazole-2-amine dihydrochloride
- R-(+)-Pramipexole dihydrochloride
- RPPX
- (R)-Pramipexole (hydrochloride)
- Pramipexole EP Impurity D DiHCl
- DexpraMipexole (dihydrochloride)
- Pramipexole dihydrochloride impurity IV
- Pramipexole Dihydrochloride Hydrate IMP
- Pramipexole Dihydrochloride Hydrate Impurity
- Pramipexole Dihydrochloride Impurity
- I9038PKO43
- Dexpramipexole 2Hcl
- C10H17N3S.2ClH
- BDBM50226714
- 2946AH
- API0005554
- Dexpramipexole dihydrochloride, >=98% (HPLC)
- Pram
- (R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride // (R)-Pramipexole dihydrochloride
- DA-52472
- EX-A398
- 2-Imino-N-propyl-2,3,4,5,6,7-hexahydro-1,3-benzothiazol-6-amine--hydrogen chloride (1/2)
- KNS-760704 ANHYDROUS
- DEXPRAMIPEXOLE DIHYDROCHLORIDE ANHYDROUS
- DEXPRAMIPEXOLE DIHYDROCHLORIDE [WHO-DD]
- CHEMBL3216394
- DTXSID20920539
- Q27280587
- SCHEMBL910147
- (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;dihydrochloride
- AKOS030485953
- (6R)-6-N-PROPYL-4,5,6,7-TETRAHYDRO-1,3-BENZOTHIAZOLE-2,6-DIAMINE DIHYDROCHLORIDE
- C71186
- 2,6-BENZOTHIAZOLEDIAMINE, 4,5,6,7-TETRAHYDRO-N(SUP 6)-PROPYL-, HYDROCHLORIDE, (1:2), (6R)-
- 104632-27-1
- (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diaminedihydrochloride
- HY-17355A
-
- MDL： MFCD13186799
- Inchi： 1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m1../s1
- InChI Key： QMNWXHSYPXQFSK-XCUBXKJBSA-N
- SMILES： Cl[H].Cl[H].S1C(N([H])[H])=NC2=C1C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[H]
Computed Properties
- Exact Mass: 283.06800
- Monoisotopic Mass: 283.0676742g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 4
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 16
- Rotatable Bond Count: 3
- Complexity: 188
- Covalently-Bonded Unit Count: 3
- Defined Atom Stereocenter Count: 1
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 79.2
Experimental Properties
- Solubility: H2O: >15mg/mL
- PSA: 79.91000
- LogP: 3.50720
Dexpramipexole dihydrochloride Security Information
- Signal Word：Warning
- Hazard Statement： H315-H319-H335
- Warning Statement： P261-P305+P351+P338
- Hazardous Material transportation number：NONH for all modes of transport
- Hazard Category Code： 36/37/38
- Safety Instruction： 26
-
Hazardous Material Identification：
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Dexpramipexole dihydrochloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | PHR1824-50MG |
Dexpramipexole dihydrochloride |
104632-27-1 | Pharmaceutical Secondary Standard; Certified Reference Material | 50MG |
￥8948.98 | 2022-02-23 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 1553815-25MG |
Pramipexole Related Compound D |
104632-27-1 | 25mg |
￥10117.6 | 2023-09-06 | ||
| TRC | P700745-5mg |
(R)-Pramipexole Dihydrochloride |
104632-27-1 | 5mg |
$98.00 | 2023-05-17 | ||
| TRC | P700745-10mg |
(R)-Pramipexole Dihydrochloride |
104632-27-1 | 10mg |
$136.00 | 2023-05-17 | ||
| TRC | P700745-25mg |
(R)-Pramipexole Dihydrochloride |
104632-27-1 | 25mg |
$ 266.00 | 2023-09-06 | ||
| TRC | P700745-50mg |
(R)-Pramipexole Dihydrochloride |
104632-27-1 | 50mg |
$ 500.00 | 2023-09-06 | ||
| TRC | P700745-100mg |
(R)-Pramipexole Dihydrochloride |
104632-27-1 | 100mg |
$ 885.00 | 2023-09-06 | ||
| TRC | P700745-250mg |
(R)-Pramipexole Dihydrochloride |
104632-27-1 | 250mg |
$1742.00 | 2023-05-17 | ||
| ChemScence | CS-1195-10mg |
Dexpramipexole (dihydrochloride) |
104632-27-1 | 99.71% | 10mg |
$90.0 | 2021-09-02 | |
| ChemScence | CS-1195-25mg |
Dexpramipexole (dihydrochloride) |
104632-27-1 | 99.71% | 25mg |
$190.0 | 2021-09-02 |
Dexpramipexole dihydrochloride Related Literature
-
Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
-
J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
-
Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
-
Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
-
Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
104632-27-1 (Dexpramipexole dihydrochloride) Related Products
- 1254579-15-1((6S)-6-N-Ethyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine)
- 191712-81-9((S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride hydrate)
- 1217601-58-5((S)-Pramipexole-(N-Propyl-2,2,3,3,3-d5) Dihydrochloride)
- 908244-04-2(R-Pramipexole 2HCl Monohydrate)
- 104617-31-4(2-Benzothiazolamine, 4,5,6,7-tetrahydro-6-(1-piperidinyl)-,dihydrochloride)
- 104632-25-9((S)-Pramipexole Dihydrochloride)
- 104632-26-0((S)-Pramipexole)
- 191217-81-9(Pramipexole dihydrochloride hydrate)
- 104632-28-2((R)-Pramipexole 2HCl)
- 104617-76-7(2,6-Benzothiazolediamine, 4,5, 6,7-tetrahydro-N6,N6-dipropyl-)
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